Article
Endocrinology & Metabolism
T. P. Ho-Le, H. T. T. Tran, J. R. Center, J. A. Eisman, H. T. Nguyen, T. Nguyen
Summary: A study on 2188 women and 1324 men found that an osteogenomic profile constructed from 62 genetic variants improved the clinical net benefit of fracture risk prediction over and above that of clinical risk factors and BMD, especially in higher risk thresholds.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Rheumatology
John J. Carey, Paulo Chih-Hsing Wu, Diane Bergin
Summary: Osteoporosis is a common non-communicable disease with a significant impact on individuals, society, and healthcare systems worldwide. Dual-energy X-ray absorptiometry (DXA) is the widely endorsed technology for assessing fracture risk, but advancements in modern technology offer opportunities for more personalized risk assessment.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Thao P. Ho-Le, Thach S. Tran, Huy G. Nguyen, Jacqueline R. Center, John A. Eisman, Tuan Nguyen
Summary: This study aims to examine the association between a polygenic risk score (PRS) and lifetime fracture risk. The findings suggest that individuals with high PRS are at a greater risk of fractures, especially hip fractures. The study highlights the potential significance of incorporating the polygenic risk score into personalized fracture risk assessment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
Lichen Ji, Wei Zhang, Xugang Zhong, Tingxiao Zhao, Xixi Sun, Senbo Zhu, Yu Tong, Junchao Luo, Youjia Xu, Di Yang, Yao Kang, Jin Wang, Qing Bi
Summary: The risk of osteoporosis is higher in breast cancer patients compared to healthy populations. Machine learning models can be used to predict the risk of osteoporosis, fracture occurrence, and prognosis. These models show better performance than current models and can improve decision making.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
M. K. Skjodt, M. T. Ernst, S. Khalid, C. Libanati, C. Cooper, A. Delmestri, K. H. Rubin, M. K. Javaid, D. Martinez-Laguna, E. Toth, D. Prieto-Alhambra, B. Abrahamsen
Summary: This study reveals a significant and persistent treatment gap in anti-osteoporosis treatment in patients aged 50 years and older who suffered major osteoporotic fractures in Denmark between 2005 and 2014, even with the inclusion of hospital-administered treatments. Strengthened post-fracture care organization and secondary fracture prevention are urgently needed.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Geriatrics & Gerontology
Abadi K. Gebre, Joshua R. Lewis, Kevin Leow, Pawel Szulc, David Scott, Peter R. Ebeling, Marc Sim, Germaine Wong, Wai H. Lim, John T. Schousboe, Douglas P. Kiel, Richard L. Prince, Alexander J. Rodriguez
Summary: Abdominal aortic calcification (AAC) is associated with lower bone mineral density (BMD) and increased fracture risk. Detecting AAC during BMD testing may provide guidance for diagnosing bone health and predicting fracture risk.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Kaisa K. Ivaska, Fiona E. McGuigan, Linnea Malmgren, Paul Gerdhem, Helena Johansson, John A. Kanis, Kristina E. Akesson
Summary: This study found that CTX, urinary OC, and TRAcP5b are predictive for fracture risk within 1 to 3 years, but are less valuable in the long term or in individuals above the age of 80.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Xiao-Peng Liu, Xian-Yu Jian, Dong-Liang Liang, Jian-Xiong Wen, Yi-Hong Wei, Jian-Di Wu, Yi-Qun Li
Summary: Patients with HF are associated with a higher risk of incident fractures, especially hip fractures. The increased risk of all incident fractures was consistent across subgroup analyses based on age, sample size, sex, and follow-up duration.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Fen Tang, Sheng Wang, Hongxia Zhao, Demeng Xia, Xin Dong
Summary: This study aims to explore the potential causal association between five mental diseases (Schizophrenia, Depression, Alzheimer's disease, Parkinson's disease, and Epilepsy) and the risk of Osteoporosis (OP). The results did not show any evidence of a causal relationship between mental diseases and the risk of OP.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
T. Tsutsui, T. Fujiwara, Y. Matsumoto, A. Kimura, M. Kanahori, S. Arisumi, A. Oyamada, M. Ohishi, K. Ikuta, K. Tsuchiya, N. Tayama, S. Tomari, H. Miyahara, T. Mae, T. Hara, T. Saito, T. Arizono, K. Kaji, T. Mawatari, M. Fujiwara, M. Takasaki, K. Shin, K. Ninomiya, K. Nakaie, Y. Antoku, Y. Iwamoto, Y. Nakashima
Summary: This study examined the long-term survival and incidence of secondary fractures after fragility hip fractures. The 5-year survival rate was 62%, with higher mortality risk in patients with GNRI < 92. The 5-year incidence of secondary fractures was 22%, which was significantly higher in patients with a BMI < 20.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Mysoon M. Al-Ansari, Shereen M. Aleidi, Afshan Masood, Eman A. Alnehmi, Mai Abdel Jabar, Maha Almogren, Mohammed Alshaker, Hicham Benabdelkamel, Anas M. Abdel Rahman
Summary: This study investigated sensitive and specific LBMD-associated protein biomarkers in patients diagnosed with ON and OP. The results identified distinctive proteomics profiles between the control, ON, and OP groups, as well as significant dysregulation in a panel of proteins common among the three groups. A comparison of proteins showed differences in their levels between ON and the control group, as well as between ON and OP. These findings provide potential protein biomarkers for further research on bone health and OP progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Yi-Qun Yang, Xing-Hao Yu, Lin Bo, Shu-Feng Lei, Fei-Yan Deng
Summary: This study examined the influence of healthy lifestyles and genetic factors on the risk of osteoporosis. The results showed that adherence to healthy lifestyles can reduce the risk of osteoporosis and fractures in individuals with different genetic risks.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
N. Li, J. P. van den Bergh, A. Boonen, C. E. Wyers, S. P. G. Bours, M. Hiligsmann
Summary: This study assessed the lifetime cost-effectiveness of a fracture liaison service (FLS) compared to no-FLS in the Netherlands and found that FLS was cost-effective for patients aged 50 years and older with a recent fracture. The implementation of FLS could lead to lifetime health-economic benefits.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Alvaro del Real, Carmen Valero, Jose M. Olmos, Jose L. Hernandez, Jose A. Riancho
Summary: Common genetic variants in the mevalonate and oestrogen pathways are associated with changes in bone mineral density in response to antiresorptive drugs, providing insights for predicting drug responses and making personalized therapeutic choices.
Article
Medicine, General & Internal
Carolyn J. Crandall, Rebecca P. Hunt, Andrea Z. LaCroix, John A. Robbins, Jean Wactawski-Wende, Karen C. Johnson, Maryam Sattari, Katie L. Stone, Julie C. Weitlauf, Tanya R. Gure, Jane A. Cauley
Summary: This study prospectively analyzed the association between subsequent fractures in postmenopausal women after initial fractures at different sites. The results showed that different types of initial fractures increased the risk of subsequent fractures of different types, and this risk was observed across all age groups of women.
Article
Rheumatology
Kwangwoo Kim, So-Young Bang, Young Bin Joo, Taehyeung Kim, Hye-Soon Lee, Changwon Kang, Sang-Cheol Bae
JOURNAL OF RHEUMATOLOGY
(2016)
Article
Multidisciplinary Sciences
Heesoo Uhm, Wooyoung Kang, Kook Sun Ha, Changwon Kang, Sungchul Hohng
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Biochemistry & Molecular Biology
Yejin Lee, Byungho Lim, Seon Woo Lee, Woo Rin Lee, Yong-In Kim, Minhyeok Kim, Hyoungseok Ju, Mi Young Kim, Suk-Jo Kang, Ji-Joon Song, J. Eugene Lee, Changwon Kang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Multidisciplinary Sciences
Woo Rin Lee, Heeju Na, Seon Woo Lee, Won-Jun Lim, Namshin Kim, J. Eugene Lee, Changwon Kang
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Seon Woo Lee, Do Youn Park, Mi-Young Kim, Changwon Kang
Article
Multidisciplinary Sciences
Wooyoung Kang, Kook Sun Ha, Heesoo Uhm, Kyuhyong Park, Ja Yil Lee, Sungchul Hohng, Changwon Kang
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Wooyoung Kang, Seungha Hwang, Jin Young Kang, Changwon Kang, Sungchul Hohng
Summary: DNA-binding proteins use sliding and hopping mechanisms for one-dimensional diffusion on DNA, while post-terminational RNA polymerases employ one-dimensional diffusion for recycling. The efficiency of reinitiation on promoters mainly depends on distance rather than direction, indicating efficient orientation change during hopping diffusion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yuan Qian, Gabriel Arellano, Igal Ifergan, Jean Lin, Caroline Snowden, Taehyeung Kim, Jane Joy Thomas, Calvin Law, Tianxia Guan, Roumen D. Balabanov, Susan M. Kaech, Stephen D. Miller, Jaehyuk Choi
Summary: Inappropriate CD4(+) T cell differentiation can affect immune response and autoimmune diseases. The study identified a key role for Zinc finger E-box-binding homeobox (ZEB1) in regulating autoimmune inflammation, particularly through inhibition of JAK-STAT signaling. ZEB1 and JAK2 downregulation reduces pathogenic cytokine expression in T cells from MS patients, suggesting a potential targetable mechanism for regulating disease-related inflammation.
Article
Multidisciplinary Sciences
Eunho Song, Heesoo Uhm, Palinda Ruvan Munasingha, Seungha Hwang, Yeon-Soo Seo, Jin Young Kang, Changwon Kang, Sungchul Hohng
Summary: This study provides evidence that Rho-mediated transcription termination can occur via three kinetically different routes, shedding light on the mechanism of transcription termination.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Eunho Song, Seungha Hwang, Palinda Ruvan Munasingha, Yeon-Soo Seo, Jin Young Kang, Changwon Kang, Sungchul Hohng
Summary: In this study on bacterial Rho factor-dependent terminators, it was found that the three Rho-dependent termination routes operate compatibly and their efficiency depends on the termination pauses. The most abundant route involves Rho catching up with a paused RNA polymerase, leading to simultaneous release of transcript RNA and template DNA. The fastest route results in RNA-only release and recycling of RNAP, while the slowest route facilitates simultaneous releases. The termination efficiency of stand-by Rho positively correlates with pause duration, contrary to previous speculation.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Gunhyoung Lim, Seungha Hwang, Kilwon Yu, Jin Young Kang, Changwon Kang, Sungchul Hohng
Summary: In this single-molecule study, researchers discovered that actively transcribing RNA polymerase can act as an efficient sensor for DNA double-strand breaks (DSBs), resulting in the formation of R-loops. The efficiency of R-loop formation is influenced by DNA end structures and can interfere with transcription and prevent subsequent rounds of transcription. These findings provide valuable insights into the initiation of DSB repair on transcription templates across different organisms.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Rheumatology
Taehyeung Kim, Sang-Cheol Bae, Changwon Kang
ARTHRITIS RESEARCH & THERAPY
(2020)
Article
Materials Science, Biomaterials
Sean D. Allen, Yu-Gang Liu, Taehyeung Kim, Sharan Bobbala, Sijia Yi, Xiaohan Zhang, Jaehyuk Choi, Evan A. Scott
BIOMATERIALS SCIENCE
(2019)
Article
Rheumatology
Eun Ha Kang, Sewon Kim, Min Young Park, Ji Yong Choi, In Ah Choi, Min Jung Kim, You-Jung Ha, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Changwon Kang, Yeong Wook Song
ARTHRITIS RESEARCH & THERAPY
(2017)