Article
Endocrinology & Metabolism
Nicholas C. Harvey, Eric Orwoll, Timothy Kwok, Magnus K. Karlsson, Bjorn E. Rosengren, Eva Ribom, Jane A. Cauley, Peggy M. Cawthon, Kristine Ensrud, Enwu Liu, Alfonso J. Cruz-Jentoft, Roger A. Fielding, Cyrus Cooper, John A. Kanis, Mattias Lorentzon, Claes Ohlsson, Dan Mellstrom, Helena Johansson, Eugene McCloskey
Summary: Adjustment for femoral neck bone mineral density (fnBMD) reduces the predictive value for fracture of sarcopenia definitions based on appendicular lean mass (ALM), but inclusion of physical performance measures strengthens it. Severe sarcopenia definitions incorporating chair stand time, gait speed, and grip strength demonstrate the highest predictability for fracture, even at low prevalence levels.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
I-Ting Liu, Fu-Wen Liang, Chia-Chun Li, Yin-Fan Chang, Zih-Jie Sun, Tsung-Hsueh Lu, Chin-Sung Chang, Chih-Hsing Wu
Summary: The Taiwan FRAX(R) calculator has been validated for predicting incident fractures and cutoff values have been proposed for fracture risk prediction in Taiwanese individuals.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
Mattias Lorentzon, Helena Johansson, Nicholas C. Harvey, Enwu Liu, Liesbeth Vandenput, Carolyn J. Crandall, Jane A. Cauley, Meryl S. LeBoff, Eugene McCloskey, John A. Kanis
Summary: In a combined analysis of two Women's Health Initiative hormone therapy trials, menopausal hormone therapy reduces fracture risk in postmenopausal women regardless of baseline FRAX fracture probability and falls history.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
H. Johansson, G. Naureen, R. Iqbal, L. Jafri, A. H. Khan, M. Umer, E. Liu, L. Vandenput, M. Lorentzon, E. V. McCloskey, J. A. Kanis, N. C. Harvey
Summary: By comparing the utility of intervention thresholds at a T-score <= - 2.5 or based on a FRAX probability, it was found that the FRAX-based threshold was more effective in identifying women at high fracture risk, while the T-score threshold showed lower sensitivity, and the associated fracture risk decreased significantly with age.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Helena Johansson, Sapna S. Dela, Bilkish Cassim, Farhanah Paruk, Susan L. Brown, Magda Conradie, Nicholas C. Harvey, Johannes D. Jordaan, Asgar A. Kalla, Enwu Liu, Mattias Lorentzon, Mkhululi Lukhele, Eugene V. McCloskey, Ozayr Mohamed, Pariva Chutterpaul, Liesbeth Vandenput, John A. Kanis
Summary: Ethnic-specific FRAX models were created based on hip fracture rates in South Africa to assess fracture risk. The probabilities varied among different ethnicities, with Indians generally having higher probabilities than Coloured and Black South Africans. In women aged 50, using a BMD T score of -2.5 SD as an intervention threshold led to approximately double the FRAX probabilities compared to those with average BMD and no risk factors. The increment in risk associated with the BMD threshold decreased with age, with T score of -2.5 SD no longer a risk factor for women aged 80 or older.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
Yousef A. L. Saleh, Riad A. Sulimani, Shaker Alomary, Yassmeen Alnajjar, Liesbeth Vandenput, Enwu Liu, Mattias Lorentzon, Nicholas C. Harvey, Eugene McCloskey, Helena Johansson, John A. Kanis
Summary: A study in Saudi Arabia analyzed the incidence of hip fractures to develop a FRAX tool for fracture prediction and compared fracture probabilities with neighboring countries. The estimated number of hip fractures in Saudi Arabia is predicted to increase nearly sevenfold by 2050, but the probabilities of major osteoporotic fractures or hip fractures are lower due to higher mortality rates.
ARCHIVES OF OSTEOPOROSIS
(2022)
Review
Endocrinology & Metabolism
M. Schini, H. Johansson, N. C. Harvey, M. Lorentzon, J. A. Kanis, E. V. McCloskey
Summary: FRAX is a simple-to-use fracture risk calculator that assists clinicians in determining the need for further investigation and treatment to prevent fractures. This review explores the literature on osteoporosis and how FRAX has changed its management, presenting the characteristics of the tool and discussing the use of thresholds. Arguments for considering screening with FRAX are presented, along with an assessment of the limitations of FRAX.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, Eugene McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis, William D. Leslie
Summary: This study found that medical comorbidity is associated with fracture risk and can increase the risk of fractures independently of FRAX. By using complex and simple measures of medical comorbidity, FRAX-based risk estimates can be modified to capture the increased fracture risk associated with multiple comorbid conditions in older patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Nicholas C. Harvey, John A. Kanis, Enwu Liu, Cyrus Cooper, Mattias Lorentzon, Jennifer W. Bea, Laura Carbone, Elizabeth M. Cespedes Feliciano, Deepika R. Laddu, Peter F. Schnatz, Aladdin H. Shadyab, Marcia L. Stefanick, Jean Wactawski-Wende, Carolyn J. Crandall, Helena Johansson, Eugene McCloskey
Summary: In the WHI study, associations between baseline appendicular lean mass (ALM) and incident fractures, falls, and mortality in older postmenopausal women were investigated. Higher ALM/height(2) was associated with lower risk of MOF but higher risk of death. These associations were independent of prior falls but attenuated by other factors such as FRAX probability and FN BMD T-score.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Lan Yang, Mary Dempsey, Attracta Brennan, Bryan Whelan, E. Erjiang, Tingyan Wang, Rebecca Egan, Kelly Gorham, Fiona Heaney, Catherine Armstrong, Guadalupe Morote Ibarrola, Amina Gsel, Ming J. Yu, John Carey
Summary: The appropriate use of FRAX can reduce the need for DXA scans and identify individuals at the highest risk. Comparing FRAX results with and without inclusion of BMD suggests that clinicians should carefully consider the importance of including BMD in fracture risk estimation for individual patients.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Endocrinology & Metabolism
B. H. Albergaria, C. A. F. Zerbini, M. Lazaretti-Castro, S. R. Eis, T. Vilaca, H. Johansson, N. C. Harvey, E. Liu, L. Vandenput, M. Lorentzon, M. Schini, E. McCloskey, J. A. Kanis
Summary: Compared to the original FRAX model, the updated model for Brazil showed consistently lower fracture probabilities. However, there was minimal difference in the rank order of fracture probabilities between the two models.
ARCHIVES OF OSTEOPOROSIS
(2023)
Review
Rheumatology
Mattias Lorentzon, Bo Abrahamsen
Summary: This review provides an update on the most important new cohort studies within osteoporosis, emphasizing the importance of timely identification and treatment of high-risk patients, and suggesting new research directions and strategies.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Patrick Pflueger, Felix N. Harder, Karoline Mueller, Lukas Willinger, Peter Biberthaler, Moritz Croenlein
Summary: Trimalleolar ankle fractures predominantly affect younger men and older women, with postmenopausal women having lower bone mineral density and a higher risk of fractures. This study aimed to analyze the association between patient characteristics and cortical bone thickness of the distal tibia in trimalleolar ankle fractures. The results showed that older age and female sex were associated with reduced cortical bone thickness and an increased risk of subsequent osteoporotic fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Tanchanok Chattaris, Laiji Yang, Helena Johansson, Shivani Sahni, Elizabeth J. Samelson, Douglas P. Kiel, Sarah D. Berry
Summary: This study compared the performance of FRAX in identifying fracture risk in individuals with and without frailty. It found that FRAX had lower discrimination ability in individuals with frailty, but this improved when bone mineral density (BMD) was included. The study suggests that BMD is an important factor for fracture prediction in frail individuals.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Health Care Sciences & Services
Avishai M. Tsur, Paula David, Abdulla Watad, Daniel Nissan, Arnon D. Cohen, Howard Amital
Summary: This study found that patients with ankylosing spondylitis are more likely to develop hip fractures earlier and more frequently compared to a matched cohort. It suggests that these patients might benefit from more proactive screening, mitigation, and prevention of risk factors for hip fractures.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Rheumatology
Benjamin G. Faber, Monika Frysz, April E. Hartley, Raja Ebsim, Cindy G. Boer, Fiona R. Saunders, Jennifer S. Gregory, Richard M. Aspden, Nicholas C. Harvey, Lorraine Southam, William Giles, Christine L. Le Maitre, J. Mark Wilkinson, Joyce B. J. van Meurs, Eleftheria Zeggini, Timothy Cootes, Claudia Lindner, John P. Kemp, George Davey Smith, Jonathan H. Tobias
Summary: This study examined the genetic architecture of cam morphology using the alpha angle (AA) as a measure and found a bidirectional relationship between AA and hip osteoarthritis (OA). The results suggest that a genetic predisposition to hip OA contributes to the relationship between hip OA and cam morphology, indicating the importance of genetic factors in the development of these conditions.
ARTHRITIS & RHEUMATOLOGY
(2023)
Review
Endocrinology & Metabolism
Rebecca J. Moon, Harry D. Green, Stefania D'Angelo, Keith M. Godfrey, Justin H. Davies, Elizabeth M. Curtis, Cyrus Cooper, Nicholas C. Harvey
Summary: A systematic review and meta-analysis showed that moderate- to high-dose vitamin D supplementation during pregnancy has a positive effect on offspring bone mineralisation, with increased bone mineral density (BMD) in children aged 4-6 years and a smaller effect on bone mineral content.
OSTEOPOROSIS INTERNATIONAL
(2023)
Letter
Allergy
Sarah El-Heis, Sarah R. Crozier, Nicholas C. Harvey, Eugene Healy, Keith M. Godfrey
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Elizabeth Remfry, Maddalena Ardissino, Celeste McCracken, Liliana Szabo, Stefan Neubauer, Nicholas C. Harvey, Mamas A. Mamas, John Robson, Steffen E. Petersen, Zahra Raisi-Estabragh
Summary: This study examined the sex-based differences in the association of vascular risk factors with incident cardiovascular events. The results showed that age, deprivation, hypertension, and smoking were more strongly associated with the risk of myocardial infarction in women, while low-density lipoprotein cholesterol and apolipoprotein A were more strongly associated with the risk in men. Age and apolipoprotein A were more strongly associated with the risk of stroke in women. These findings highlight the importance of sex-specific preventive strategies.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Orthopedics
S. V. Heppenstall, R. Ebsim, F. R. Saunders, C. Lindner, J. S. Gregory, R. M. Aspden, N. C. Harvey, T. Cootes, J. H. Tobias, M. Frysz, B. G. Faber
Summary: The study found that geometric parameters derived from dual-energy x-ray absorptiometry (DXA) scans in the UK Biobank were related to the risk of hip osteoarthritis (HOA). Specifically, greater femoral neck width (FNW) and hip axis length (HAL) were associated with an increased risk of HOA, while greater diameter of the femoral head (DFH) appeared to be protective. FNW was also independently associated with the risk of hospital diagnosed HOA (HESOA) and total hip replacement (THR).
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Endocrinology & Metabolism
J. A. Kanis, H. Johansson, E. McCloskey, E. Liu, K. E. Akesson, F. A. Anderson, R. Azagra, C. L. Bager, C. Beaudart, H. A. Bischoff-Ferrari, E. Biver, O. Bruyere, J. A. Cauley, J. R. Center, R. Chapurlat, C. Christiansen, C. Cooper, C. J. Crandall, S. R. Cummings, J. A. P. da Silva, B. Dawson-Hughes, A. Diez-Perez, A. B. Dufour, J. A. Eisman, P. J. M. Elders, S. Ferrari, Y. Fujita, S. Fujiwara, C. -c. Glueer, I. Goldshtein, D. Goltzman, V. Gudnason, J. Hall, D. Hans, M. Hoff, R. J. Hollick, M. Huisman, M. Iki, S. Ish-Shalom, G. Jones, M. K. Karlsson, S. Khosla, D. P. Kiel, W. -p. Koh, F. Koromani, M. A. Kotowicz, H. Kroger, T. Kwok, O. Lamy, A. Langhammer, B. Larijani, K. Lippuner, D. Mellstrom, T. Merlijn, A. Nordstrom, P. Nordstrom, T. W. O'Neill, B. Obermayer-Pietsch, C. Ohlsson, E. S. Orwoll, J. A. Pasco, F. Rivadeneira, A. -M. Schott, E. J. Shiroma, K. Siggeirsdottir, E. M. Simonsick, E. Sornay-Rendu, R. Sund, K. M. A. Swart, P. Szulc, J. Tamaki, D. J. Torgerson, N. M. van Schoor, T. P. van Staa, J. Vila, N. J. Wareham, N. C. Wright, N. Yoshimura, M. C. Zillikens, M. Zwart, L. Vandenput, N. C. Harvey, M. Lorentzon, W. D. Leslie
Summary: A large international meta-analysis finds that a previous history of fracture is associated with an increased risk of future fractures, regardless of age, sex, and bone mineral density. The study highlights the importance of considering previous fracture history as a risk factor for fracture prevention strategies.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
M. Kassim Javaid, M. Calo, S. Wullich, Z. Mohsin, E. Castro Osorio, A. Medina Orjuela, C. Arteaga Unigarro, L. Mendez-Sanchez, J. Torres Naranjo, L. Tikle Vieira, K. Kuraoka Tutiya, A. Manoel Inacio, A. Olascoaga-Gomez de Leon, J. Carlos Viveros Garcia, C. Habib, F. Subies, J. P. Guyot, M. Diehl, G. Carabelli, A. Soulie, C. Cooper
Summary: By implementing the mentorship programme for fracture liaison service (FLS) in Latin America, 64 FLS were established and 17,205 patients were covered.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Kathryn R. Hesketh, Janis Baird, Sarah R. Crozier, Keith M. Godfrey, Nicholas C. Harvey, Cyrus Cooper, Esther M. F. van Sluijs
Summary: This study aimed to explore the relationship between activity behaviors before/during pregnancy and later parenthood. The results showed that women who sat for long periods of time before/during pregnancy were more sedentary 4-7 years postpartum, and those who engaged in moderate-/strenuous exercise before/during pregnancy were more active in later parenthood.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Review
Geriatrics & Gerontology
Charlotte Beaudart, Jean-Yves Reginster, Jotheeswaran Amuthavalli Thiyagarajan, Ivan Bautmans, Juergen Bauer, Nansa Burlet, Matteo Cesari, Antonio Cherubini, Cyrus Cooper, Alfonso J. Cruz-Jentoft, Bess Dawson-Hughes, Roger A. Fielding, Nicholas C. Harvey, Francesco Landi, Andrea Laslop, Stefania Maggi, Beatriz Montero-Errasquin, Prieto Yerro Maria Concepcion, Yves Rolland, Rene Rizzoli, Marjolein Visser, Olivier Bruyere
Summary: Patient perspectives are crucial in evaluating health interventions, and the availability of specific Patient Reported Outcome Measures is important. The SarQoL questionnaire is the only validated instrument for assessing health-related quality of life in sarcopenia patients. It has been widely studied and shown to be reliable, valid, and responsive to change. However, more research is needed to measure its responsiveness in interventional studies and to establish a cut-off score for defining low quality of life. Furthermore, the questionnaire should be studied in different populations, not just community-dwelling older individuals with sarcopenia.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Leo D. Westbury, Nicholas R. Fuggle, Diogo Pereira, Hiroyuki Oka, Noriko Yoshimura, Noriyuki Oe, Sasan Mahmoodi, Mahesan Niranjan, Elaine M. Dennison, Cyrus Cooper
Summary: This study aims to compare the impact of machine learning and expert observation on K&L scores, minimum joint space, and osteophyte in relation to pain and function. The analysis of participants from the Hertfordshire Cohort Study revealed that observer-derived K&L scores had higher discriminative capacity regarding pain and function, while the discriminative capacity of minimum joint space and osteophyte in relation to pain and function was lower among men.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
B. H. Albergaria, C. A. F. Zerbini, M. Lazaretti-Castro, S. R. Eis, T. Vilaca, H. Johansson, N. C. Harvey, E. Liu, L. Vandenput, M. Lorentzon, M. Schini, E. McCloskey, J. A. Kanis
Summary: Compared to the original FRAX model, the updated model for Brazil showed consistently lower fracture probabilities. However, there was minimal difference in the rank order of fracture probabilities between the two models.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Geriatrics & Gerontology
Elaine M. Dennison, Faidra Laskou, Leo D. Westbury, Gregorio Bevilacqua, Nicholas R. Fuggle, Toshiko Iidaka, Chiaki Horii, Sakae Tanaka, Noriko Yoshimura, Cyrus Cooper
Summary: This study reports on the prevalence of grip strength and its correlates in UK and Japanese populations. The results suggest that the correlates of muscle weakness are similar in both populations.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Nay Aung, Qingning Wang, Stefan van Duijvenboden, Richard Burns, Svetlana Stoma, Zahra Raisi-Estabragh, Selda Ahmet, Elias Allara, Angela Wood, Emanuele Di Angelantonio, John Danesh, Patricia B. Munroe, Alistair Young, Nicholas C. Harvey, Veryan Codd, Christopher P. Nelson, Steffen E. Petersen, Nilesh J. Samani
Summary: This study found that longer LTL is associated with a larger heart, better cardiac function, and a lower risk of incident HF in middle age.
Article
Geriatrics & Gerontology
Roshan Rambukwella, Leo D. Westbury, Camille Pearse, Kate A. Ward, Cyrus Cooper, Elaine M. Dennison
Summary: This study investigated hospital admission types experienced by older people and examined baseline risk factors for subsequent admission/death. The findings showed that cardiovascular and respiratory diseases were the most common types of admission. Older age, poorer physical function, and poorer self-rated health were baseline risk factors associated with admission/death.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)