A Biological Route to Conjugated Alkenes: Microbial Production of Hepta-1,3,5-triene

Complete Reconstitution and Deorphanization of the 3 MDa Nocardiosis-Associated Polyketide Synthase

(2020) Kai P. Yuet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers

(2020) Christopher J. Robinson et al.   METABOLIC ENGINEERING

Enzymatic C–H activation of aromatic compounds through CO2 fixation

(2020) Godwin A. Aleku et al.   Nature Chemical Biology

An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments

(2019) Gina Luisa Carina Grammbitter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution and Diversity of Assembly-Line Polyketide Synthases

(2019) Aleksandra Nivina et al.   CHEMICAL REVIEWS

Reconstitution of a Type II Polyketide Synthase that Catalyzes Polyene Formation

(2018) Danyao Du et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway

(2018) Thibault Annaval et al.   ACS Chemical Biology

Production of a Novel Amide-Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster inStreptomycessp. MSC090213JE08

(2016) Danyao Du et al.   CHEMBIOCHEM

In Vitro Investigation of Crosstalk between Fatty Acid and Polyketide Synthases in the Andrimid Biosynthetic Assembly Line

(2016) Fumihiro Ishikawa et al.   CHEMBIOCHEM

Biobased production of alkanes and alkenes through metabolic engineering of microorganisms

(2016) Min-Kyoung Kang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Elucidation of the Concise Biosynthetic Pathway of the Communesin Indole Alkaloids

(2015) Hsiao-Ching Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Narrowing the gap between the promise and reality of polyketide synthases as a synthetic biology platform

(2014) Sean Poust et al.   CURRENT OPINION IN BIOTECHNOLOGY

Non-isoprenoid polyene natural products – structures and synthetic strategies

(2014) Katrina S. Madden et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Analysis and Refactoring of the A-74528 Biosynthetic Pathway

(2013) Jay T. Fitzgerald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation

(2013) Bo Wang et al.   ORGANIC LETTERS

New Nystatin-Related Antifungal Polyene Macrolides with Altered Polyol Region Generated via Biosynthetic Engineering of Streptomyces noursei

(2011) Trygve Brautaset et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Styrene biosynthesis from glucose by engineered E. coli

(2011) Rebekah McKenna et al.   METABOLIC ENGINEERING

2,4,6-Octatrienoic acid is a novel promoter of melanogenesis and antioxidant defence in normal human melanocytes via PPAR-γ activation

(2011) Enrica Flori et al.   Pigment Cell & Melanoma Research

Mechanism and Engineering of Polyketide Chain Initiation in Fredericamycin Biosynthesis

(2010) Abhirup Das et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Production of Octaketide Polyenes by the Calicheamicin Polyketide Synthase CalE8: Implications for the Biosynthesis of Enediyne Core Structures

(2009) Katherine Belecki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GatekeepingversusPromiscuity in the Early Stages of the Andrimid Biosynthetic Assembly Line

(2008) Nathan A. Magarvey et al.   ACS Chemical Biology