Journal
ACS CATALYSIS
Volume 6, Issue 4, Pages 2201-2204Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.5b02850
Keywords
biohybrid; NADPH regeneration; photocatalysis; biocatalysis; quantum dots
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Funding
- Laboratory Directed Research and Development (LDRD) Program at the National Renewable Energy Laboratory
- U.S. Department of Energy, Office of Biological and Environmental Research (BER)
- U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering [DE-SC0010334]
- U.S. Department of Energy (DOE) [DE-SC0010334] Funding Source: U.S. Department of Energy (DOE)
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We report the characterization of biohybrid complexes of CdSe quantum dots and ferredoxin NADP(-)(+)reductase for photocatalytic regeneration of NADPH. Illumination with visible light led to reduction of NADP+ to NADPH, with an apparent k(cat) of 1400 h(-1). Regeneration of NADPH was coupled to reduction of aldehydes to alcohols catalyzed by a NADPH-dependent alcohol dehydrogenase, Aldehyde with each NADPH molecule recycled an average of 7.5 times. The quantum yield both of NADPH and alcohol production were 5-6% for both products. Light-driven NADPH regeneration was also demonstrated in a multienzyme system, showing the capacity of QD-FNR complexes to drive continuous NADPH-dependent transformations.
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