KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
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Title
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
Authors
Keywords
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Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-02-21
DOI
10.1038/s41467-021-21422-x
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Note: Only part of the references are listed.- Homogeneous dual-parametric coupled assay for simultaneous nucleotide exchange and KRAS/RAF-RBD interaction monitoring
- (2020) Kari Kopra et al. ANALYTICAL CHEMISTRY
- The Plasma Membrane as a Competitive Inhibitor and Positive Allosteric Modulator of KRas4B Signaling
- (2020) Chris Neale et al. BIOPHYSICAL JOURNAL
- Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization
- (2020) Nicholas P. D. Liau et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Frequency of Ras Mutations in Cancer
- (2020) Ian A. Prior et al. CANCER RESEARCH
- Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane
- (2020) Zhenhao Fang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structures of N-terminally processed KRAS provide insight into the role of N-acetylation
- (2019) Srisathiyanarayanan Dharmaiah et al. Scientific Reports
- Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases
- (2019) Yasushi Kondo et al. SCIENCE
- Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes
- (2019) Eunyoung Park et al. NATURE
- KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
- (2018) Chiara Ambrogio et al. CELL
- Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling
- (2018) Shuai Li et al. STRUCTURE
- Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain
- (2018) Timothy Travers et al. Scientific Reports
- A “Tug of War” Maintains a Dynamic Protein–Membrane Complex: Molecular Dynamics Simulations of C-Raf RBD-CRD Bound to K-Ras4B at an Anionic Membrane
- (2018) Zhen-Lu Li et al. ACS Central Science
- Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane
- (2018) Bindu Lakshman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SHOC2–MRAS–PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis
- (2018) Lucy C. Young et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of RAS function through targeting an allosteric regulatory site
- (2016) Russell Spencer-Smith et al. Nature Chemical Biology
- Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design
- (2016) Jonathan M. L. Ostrem et al. NATURE REVIEWS DRUG DISCOVERY
- The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions
- (2016) Hossein Nakhaeizadeh et al. PLoS One
- Regulation of RAF protein kinases in ERK signalling
- (2015) Hugo Lavoie et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD
- (2015) Susan K. Fetics et al. STRUCTURE
- Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling
- (2014) Jacob R. Haling et al. CANCER CELL
- Deciphering key features in protein structures with the new ENDscript server
- (2014) Xavier Robert et al. NUCLEIC ACIDS RESEARCH
- Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers
- (2013) Jiancheng Hu et al. CELL
- Collaboration gets the most out of software
- (2013) Andrew Morin et al. eLife
- Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
- (2011) F. Sievers et al. Molecular Systems Biology
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- GermlineBRAFmutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: Molecular diversity and associated phenotypic spectrum
- (2009) Anna Sarkozy et al. HUMAN MUTATION
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