Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane

Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement

(2020) Ki‐Young Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

K-Ras G-domain binding with signaling lipid Phosphatidyl inositol (4,5) phosphate (PIP2): Membrane association, protein orientation and function

(2019) Shufen Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes

(2019) Eunyoung Park et al.   NATURE

KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS

(2018) Chiara Ambrogio et al.   CELL

Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling

(2018) Shuai Li et al.   STRUCTURE

Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain

(2018) Timothy Travers et al.   Scientific Reports

A “Tug of War” Maintains a Dynamic Protein–Membrane Complex: Molecular Dynamics Simulations of C-Raf RBD-CRD Bound to K-Ras4B at an Anionic Membrane

(2018) Zhen-Lu Li et al.   ACS Central Science

Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane

(2018) Bindu Lakshman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers

(2017) Priyanka Prakash et al.   Scientific Reports

Inhibition of prenylated KRAS in a lipid environment

(2017) Johanna M. Jansen et al.   PLoS One

Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers

(2016) H. Jang et al.   BIOCHEMICAL JOURNAL

The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding

(2016) Avik Banerjee et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population

(2016) Genta Sawada et al.   GASTROENTEROLOGY

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of RAS function through targeting an allosteric regulatory site

(2016) Russell Spencer-Smith et al.   Nature Chemical Biology

Regulation of RAF protein kinases in ERK signalling

(2015) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

(2015) Mohammad T. Mazhab-Jafari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

(2015) Xiaolin Nan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

(2015) Y. Zhou et al.   SCIENCE

Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD

(2015) Susan K. Fetics et al.   STRUCTURE

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

(2013) Jiancheng Hu et al.   CELL

Signal Integration by Lipid-Mediated Spatial Cross Talk between Ras Nanoclusters

(2013) Yong Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

A Multidomain Flexible Docking Approach to Deal with Large Conformational Changes in the Modeling of Biomolecular Complexes

(2011) Ezgi Karaca et al.   STRUCTURE

Fundamental Aspects of Protein−Protein Association Kinetics

(2009) G. Schreiber et al.   CHEMICAL REVIEWS

Improved Binding of Raf to Ras·GDP Is Correlated with Biological Activity

(2009) Christina Kiel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE