Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas

Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy

(2020) Hayley C. Affronti et al.   Nature Communications

The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models

(2019) Naiara Martínez-Vélez et al.   Nature Communications

Stalled developmental programs at the root of pediatric brain tumors

(2019) Selin Jessa et al.   NATURE GENETICS

Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas

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Beyond the Blood:Brain Barrier: The Importance of Central Nervous System (CNS) Pharmacokinetics for the Treatment of CNS Tumors, Including Diffuse Intrinsic Pontine Glioma

(2018) Katherine Elizabeth Warren   Frontiers in Oncology

Macrophage-derived IL-1β and TNF-α regulate arginine metabolism in neuroblastoma

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International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma

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The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100

(2017) Carmela De Santo et al.   INTERNATIONAL JOURNAL OF CANCER

Genomic Insights into Diffuse Intrinsic Pontine Glioma

(2017) Danielle H. Lapin et al.   Frontiers in Oncology

Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models

(2017) Tammy Hennika et al.   PLoS One

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

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Targeting polyamine metabolism for cancer therapy and prevention

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Diffuse Intrinsic Pontine Glioma: New Pathophysiological Insights and Emerging Therapeutic Targets

(2016) Tessa Johung et al.   Current Neuropharmacology

Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1

(2016) Matthew Locke et al.   Cell Reports

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

(2015) Catherine S Grasso et al.   NATURE MEDICINE

A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma

(2015) Giselle L. Saulnier Sholler et al.   PLoS One

Future Clinical Trials in DIPG: Bringing Epigenetics to the Clinic

(2015) Andres Morales La Madrid et al.   Frontiers in Oncology

DIPG in Children – What Can We Learn from the Past?

(2015) Magimairajan Issai Vanan et al.   Frontiers in Oncology

Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma

(2015) Ann M. Lozier et al.   Oncotarget

Human pontine glioma cells can induce murine tumors

(2014) Viola Caretti et al.   ACTA NEUROPATHOLOGICA

Eflornithine (DFMO) Prevents Progression of Pancreatic Cancer by Modulating Ornithine Decarboxylase Signaling

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Topical combination of diclofenac, calcipotriol, and difluoromethylornithine has beneficial effects comparable to 5-fluorouracil for the treatment of non-melanoma skin cancer in mice

(2014) Hans-Christian Pommergaard et al.   JOURNAL OF CHEMOTHERAPY

AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport

(2013) Katherine Samal et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibiting Cycloxygenase and Ornithine Decarboxylase by Diclofenac and Alpha-Difluoromethylornithine Blocks Cutaneous SCCs by Targeting Akt-ERK Axis

(2013) Aadithya Arumugam et al.   PLoS One

Diffuse intrinsic pontine gliomas: A systematic update on clinical trials and biology

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Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma

(2011) M. Monje et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Lipophilic Lysine−Spermine Conjugates Are Potent Polyamine Transport Inhibitors for Use in Combination with a Polyamine Biosynthesis Inhibitor

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