The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100

Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1–Deficient Malignant Pleural Mesothelioma

(2017) Peter W. Szlosarek et al.   JAMA Oncology

The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

(2016) M. T. S. Williams et al.   BLOOD

L-Arginine supplementation improves insulin sensitivity and beta cell function in the offspring of diabetic rats through AKT and PDX-1 activation

(2016) Diego Soares Carvalho et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The development of targeted new agents to improve the outcome for children with leukemia

(2016) Francisco Bautista et al.   Expert Opinion on Drug Discovery

Molecular basis and current strategies of therapeutic arginine depletion for cancer

(2016) Livingstone Fultang et al.   INTERNATIONAL JOURNAL OF CANCER

Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism

(2016) Anila K. Madiraju et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target

(2015) F. Mussai et al.   BLOOD

Phase I Trial of Arginine Deprivation Therapy with ADI-PEG 20 Plus Docetaxel in Patients with Advanced Malignant Solid Tumors

(2015) B. K. Tomlinson et al.   CLINICAL CANCER RESEARCH

Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma

(2015) Thomas Yau et al.   INVESTIGATIONAL NEW DRUGS

Rewired Metabolism in Drug-resistant Leukemia Cells

(2015) Claudia Stäubert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

(2015) Shiran Rabinovich et al.   NATURE

Cerebrospinal fluid asparagine depletion during pegylated asparaginase therapy in children with acute lymphoblastic leukaemia

(2014) Louise T. Henriksen et al.   BRITISH JOURNAL OF HAEMATOLOGY

L-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

(2014) M. Fletcher et al.   CANCER RESEARCH

Augmented post-remission therapy for a minimal residual disease-defined high-risk subgroup of children and young people with clinical standard-risk and intermediate-risk acute lymphoblastic leukaemia (UKALL 2003): a randomised controlled trial

(2014) Ajay Vora et al.   LANCET ONCOLOGY

Risk of late effects of treatment in children newly diagnosed with standard-risk acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor Study cohort

(2014) Stefan Essig et al.   LANCET ONCOLOGY

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

(2013) F. Mussai et al.   BLOOD

Metabolomics of the Tumor Microenvironment in Pediatric Acute Lymphoblastic Leukemia

(2013) Stefano Tiziani et al.   PLoS One

Recombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin’s lymphoma cells

(2013) X Zeng et al.   Cell Death & Disease

Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma

(2013) N Syed et al.   Cell Death & Disease

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma

(2012) Thomas Yau et al.   INVESTIGATIONAL NEW DRUGS

Effect of alternate-week versus continuous dexamethasone scheduling on the risk of osteonecrosis in paediatric patients with acute lymphoblastic leukaemia: results from the CCG-1961 randomised cohort trial

(2012) Leonard A Mattano et al.   LANCET ONCOLOGY

Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase

(2011) M P Kelly et al.   BRITISH JOURNAL OF CANCER

Characterization of the Human Ornithine Transcarbamylase 3′ Untranslated Regulatory Region

(2011) Monica Lopes-Marques et al.   DNA AND CELL BIOLOGY

Cancer cell sensitivity to arginine deprivationin vitrois not determined by endogenous levels of arginine metabolic enzymes

(2010) Yaroslav P Bobak et al.   CELL BIOLOGY INTERNATIONAL

Phase II Study of Pegylated Arginine Deiminase for Nonresectable and Metastatic Hepatocellular Carcinoma

(2010) Evan S. Glazer et al.   JOURNAL OF CLINICAL ONCOLOGY