Synthesis, Inhibitory Activity, and In Silico Modeling of Selective COX-1 Inhibitors with a Quinazoline Core
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Synthesis, Inhibitory Activity, and In Silico Modeling of Selective COX-1 Inhibitors with a Quinazoline Core
Authors
Keywords
-
Journal
ACS Medicinal Chemistry Letters
Volume -, Issue -, Pages -
Publisher
American Chemical Society (ACS)
Online
2021-03-12
DOI
10.1021/acsmedchemlett.1c00004
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cell-Specific Gene Deletion Reveals the Anti-Thrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox
- (2019) Jane A Mitchell et al. CIRCULATION RESEARCH
- Translational Theragnostic of Ovarian Cancer: Where do we stand?
- (2019) Maria Grazia Perrone et al. CURRENT MEDICINAL CHEMISTRY
- Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer
- (2018) Shreena J. Desai et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- 1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study
- (2018) Asmaa Sakr et al. BIOORGANIC CHEMISTRY
- Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)
- (2017) Gino Cingolani et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice
- (2017) Xinzhi Li et al. JOURNAL OF LIPID RESEARCH
- Anti-inflammatory activity of natural stilbenoids: A review
- (2017) Marcela Dvorakova et al. PHARMACOLOGICAL RESEARCH
- Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation
- (2017) Rosa Calvello et al. Frontiers in Neurology
- Design, synthesis and biological evaluation of 4-anilinoquinazoline derivatives as new c-myc G-quadruplex ligands
- (2016) Yin Jiang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3 H )-quinazolinones
- (2016) Alaa A.-M. Abdel-Aziz et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- COX-1 Inhibitors: Beyond Structure Toward Therapy
- (2016) Paola Vitale et al. MEDICINAL RESEARCH REVIEWS
- Selective Cyclooxygenase-1 Inhibition by P6 and Gastrotoxicity: Preliminary Investigation
- (2015) Maria Grazia Perrone et al. PHARMACOLOGY
- Interference of NSAIDs with the thrombocyte inhibitory effect of aspirin: A placebo-controlled, ex vivo, serial placebo-controlled serial crossover study
- (2012) I. L. Meek et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids
- (2011) Jeanine M.L. Roodhart et al. CANCER CELL
- Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells
- (2011) Rosa Calvello et al. PHARMACOLOGICAL RESEARCH
- Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers,
- (2010) Ranjinder S. Sidhu et al. BIOCHEMISTRY
- Selective COX-1 Inhibition: A Therapeutic Target to be Reconsidered
- (2010) M. G. Perrone et al. CURRENT MEDICINAL CHEMISTRY
- Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity
- (2010) Kathleen M Knights et al. Expert Review of Clinical Pharmacology
- Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain
- (2009) S-H Choi et al. PHARMACOGENOMICS JOURNAL
- Discovery and structure–activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists
- (2008) Masahiko Okano et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis of novel 4,6-disubstituted quinazoline derivatives, their anti-inflammatory and anti-cancer activity (cytotoxic) against U937 leukemia cell lines☆
- (2007) P. Mani Chandrika et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started