The Role of the Host Ubiquitin System in Promoting Replication of Emergent Viruses

Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response

(2021) Zengguo Cao et al.   Cellular & Molecular Immunology

Proteasome Inhibitors as a Possible Therapy for SARS-CoV-2

(2020) Lucia Longhitano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

How ISG15 combats viral infection

(2020) Brendan T. Freitas et al.   VIRUS RESEARCH

A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating

(2020) Harish N. Ramanathan et al.   mBio

Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease

(2020) Brendan T Freitas et al.   ACS Infectious Diseases

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

(2020) Maria I. Giraldo et al.   NATURE

Distinct Molecular Mechanisms of Host Immune Response Modulation by Arenavirus NP and Z Proteins

(2020) Robert J. Stott et al.   Viruses-Basel

Recent Advances and Contradictions in the Study of the Individual Roles of Ubiquitin Ligases That Regulate RIG-I-Like Receptor-Mediated Antiviral Innate Immune Responses

(2020) Hiroyuki Oshiumi   Frontiers in Immunology

Viral entry and the ubiquitin‐proteasome system

(2020) Seth M. Schneider et al.   CELLULAR MICROBIOLOGY

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

(2020) Theresa Klemm et al.   EMBO JOURNAL

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

(2019) Naoko Iwata-Yoshikawa et al.   JOURNAL OF VIROLOGY

Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma

(2019) Junling Zhuang et al.   BLOOD

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

Host-specific NS5 ubiquitination determines yellow fever virus tropism

(2019) Lisa Miorin et al.   JOURNAL OF VIROLOGY

Early Steps in Herpes Simplex Virus Infection Blocked by a Proteasome Inhibitor

(2019) Seth M. Schneider et al.   mBio

The Role of NS5 Protein in Determination of Host Cell Range for Yellow Fever Virus

(2019) Maudry Laurent-Rolle et al.   DNA AND CELL BIOLOGY

To TRIM or not to TRIM: the balance of host–virus interactions mediated by the ubiquitin system

(2019) Adam Hage et al.   JOURNAL OF GENERAL VIROLOGY

VAMP8 contributes to TRIM6-mediated type-I interferon antiviral response during West Nile virus infection

(2019) Sarah van Tol et al.   JOURNAL OF VIROLOGY

NEDD4 family ubiquitin ligases associate with LCMV Z’s PPXY domain and are required for virus budding, but not via direct ubiquitination of Z

(2019) Christopher M. Ziegler et al.   PLoS Pathogens

E3 Ligase ITCH Interacts with the Z Matrix Protein of Lassa and Mopeia Viruses and Is Required for the Release of Infectious Particles

(2019) Nicolas Baillet et al.   Viruses-Basel

The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex

(2019) Michael Bauer et al.   Cell Reports

Regulating the human HECT E3 ligases

(2018) Jasper Sluimer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of MAVS activation through post-translational modifications

(2018) Bingyu Liu et al.   CURRENT OPINION IN IMMUNOLOGY

Paramyxovirus V Proteins Interact with the RIG-I/TRIM25 Regulatory Complex and Inhibit RIG-I Signaling

(2018) Maria T. Sánchez-Aparicio et al.   JOURNAL OF VIROLOGY

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

(2018) Johannes van den Boom et al.   MOLECULAR CELL

Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease

(2018) Qiang Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B

(2018) Maria Isabel Giraldo et al.   VIRUS RESEARCH

TIM-1 Ubiquitination Mediates Dengue Virus Entry

(2018) Ophélie Dejarnac et al.   Cell Reports

Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1‐caspase‐1 axis

(2018) Yanyan Zheng et al.   EMBO JOURNAL

The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species

(2018) Daniela Niemeyer et al.   PLoS Pathogens

A patent review of the ubiquitin ligase system: 2015–2018

(2018) Xin Li et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Ubiquitination of the Cytoplasmic Domain of Influenza A Virus M2 Protein is Crucial for Production of Infectious Virus Particles

(2017) Wen-Chi Su et al.   JOURNAL OF VIROLOGY

Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress

(2017) Ziying Han et al.   JOURNAL OF VIROLOGY

The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination

(2017) Yong Hu et al.   JOURNAL OF VIROLOGY

The Ubiquitin-Proteasome System Is Necessary for Efficient Replication of Human Astrovirus

(2017) Luis A. Casorla-Pérez et al.   JOURNAL OF VIROLOGY

The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication

(2017) Preeti Bharaj et al.   JOURNAL OF VIROLOGY

CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication

(2017) Yu-Chen Lin et al.   mBio

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

(2017) Sebastian Aguirre et al.   Nature Microbiology

How Viruses Invade Cells

(2016) Fredric S. Cohen   BIOPHYSICAL JOURNAL

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

(2016) Alesha Grant et al.   Cell Host & Microbe

Ubiquitination Upregulates Influenza Virus Polymerase Function

(2016) James Kirui et al.   JOURNAL OF VIROLOGY

ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding

(2016) Ziying Han et al.   JOURNAL OF VIROLOGY

The ubiquitin-proteasome system is essential for the productive entry of Japanese encephalitis virus

(2016) Shaobo Wang et al.   VIROLOGY

Ubiquitin in Influenza Virus Entry and Innate Immunity

(2016) Alina Rudnicka et al.   Viruses-Basel

Dengue Virus Genome Uncoating Requires Ubiquitination

(2016) Laura A. Byk et al.   mBio

Regulation of Ebola virus VP40 matrix protein by SUMO

(2016) Maite Baz-Martínez et al.   Scientific Reports

The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response

(2016) Preeti Bharaj et al.   PLoS Pathogens

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

(2015) G. Manokaran et al.   SCIENCE

Evidence for Ubiquitin-Regulated Nuclear and Subnuclear Trafficking among Paramyxovirinae Matrix Proteins

(2015) Mickey Pentecost et al.   PLoS Pathogens

Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor

(2015) Weijia Cheng et al.   VIROLOGICA SINICA

The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon

(2014) Maudry Laurent-Rolle et al.   Cell Host & Microbe

Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response

(2014) Ricardo Rajsbaum et al.   IMMUNITY

Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression

(2014) Ben A. Bailey-Elkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unanchored ubiquitin in virus uncoating

(2014) Ricardo Rajsbaum et al.   SCIENCE

Influenza A virus uses the aggresome processing machinery for host cell entry

(2014) Indranil Banerjee et al.   SCIENCE

Innate immunity

(2013) Jules Hoffmann et al.   CURRENT OPINION IN IMMUNOLOGY

Proteasomes Activate Aggresome Disassembly and Clearance by Producing Unanchored Ubiquitin Chains

(2013) Rui Hao et al.   MOLECULAR CELL

Pooled RNAi screen identifies ubiquitin ligase Itch as crucial for influenza A virus release from the endosome during virus entry

(2013) W.-C. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling

(2013) Juliet Morrison et al.   PLoS Pathogens

A Virological View of Innate Immune Recognition

(2012) Akiko Iwasaki   Annual Review of Microbiology

Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain

(2012) Martha Schneider et al.   JOURNAL OF VIROLOGY

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

(2012) Allison L Totura et al.   Current Opinion in Virology

DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING

(2012) Sebastian Aguirre et al.   PLoS Pathogens

Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission

(2010) Jeremy S. Rossman et al.   CELL

The Ubiquitin Ligase Riplet Is Essential for RIG-I-Dependent Innate Immune Responses to RNA Virus Infection

(2010) Hiroyuki Oshiumi et al.   Cell Host & Microbe

Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication

(2010) Tsai-Ling Liao et al.   EMBO JOURNAL

Ubiquitin-Regulated Nuclear-Cytoplasmic Trafficking of the Nipah Virus Matrix Protein Is Important for Viral Budding

(2010) Yao E. Wang et al.   PLoS Pathogens

Proteasome inhibitors block HIV-1 replication by affecting both cellular and viral targets

(2009) Liang Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Regulation of Marburg virus (MARV) budding by Nedd4.1: a different WW domain of Nedd4.1 is critical for binding to MARV and Ebola virus VP40

(2009) S. Urata et al.   JOURNAL OF GENERAL VIROLOGY

NS5 of Dengue Virus Mediates STAT2 Binding and Degradation

(2009) J. Ashour et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF- B Signaling

(2009) M. Frieman et al.   JOURNAL OF VIROLOGY

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY