Self-Sufficient Class VII Cytochromes P450: From Full-Length Structure to Synthetic Biology Applications

Petroleum-Tolerant Rhizospheric Bacteria: Isolation, Characterization and Bioremediation Potential

(2020) Jéssica Aparecida Viesser et al.   Scientific Reports

Characterization of the structure and interactions of P450 BM3 using hybrid mass spectrometry approaches

(2020) Laura N. Jeffreys et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visible light catalyzed anti-markovnikov hydration of styrene to 2-phenylethanol: From batch to continuous

(2020) Yuhang Chen et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY

Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase

(2020) Lilan Zhang et al.   Nature Communications

Natural Compounds as Pharmaceuticals: The Key Role of Cytochromes P450 Reactivity

(2020) Giovanna Di Nardo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Redox Partners: Function Modulators of Bacterial P450 Enzymes

(2020) Shengying Li et al.   TRENDS IN MICROBIOLOGY

Engineering substrate recognition sites of cytochrome P450 monooxygenase CYP116B3 from Rhodococcus ruber for enhanced regiospecific naphthalene hydroxylation

(2020) Sha Tao et al.   Molecular Catalysis

Bio-cleaning of nitrate salt efflorescence on stone samples using extremophilic bacteria

(2019) Ida Romano et al.   Scientific Reports

Cytochrome P450 Monooxygenases in Biotechnology and Synthetic Biology

(2019) Vlada B. Urlacher et al.   TRENDS IN BIOTECHNOLOGY

Regio- and Enantio-selective Chemo-enzymatic C−H-Lactonization of Decanoic Acid to (S )-δ-Decalactone

(2019) Jack Manning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti-Markovnikov alcohols via epoxide hydrogenation through cooperative catalysis

(2019) Chengbo Yao et al.   SCIENCE

Crystal structure of bacterial CYP116B5 heme domain: New insights on class VII P450s structural flexibility and peroxygenase activity

(2019) Alberto Ciaramella et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Genome of Labrenzia sp. PHM005 Reveals a Complete and Active Trans-AT PKS Gene Cluster for the Biosynthesis of Labrenzin

(2019) Dina Kačar et al.   Frontiers in Microbiology

Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications

(2019) Zhong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxide-driven catalysis of the heme domain of A. radioresistens cytochrome P450 116B5 for sustainable aromatic rings oxidation and drug metabolites production

(2019) Alberto Ciaramella et al.   New Biotechnology

The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s

(2018) Michele Tavanti et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure and function of the cytochrome P450 peroxygenase enzymes

(2018) Andrew W. Munro et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Modulation of the interaction between human P450 3A4 and B. megaterium reductase via engineered loops

(2018) Silvia Castrignanò et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Panel of New Thermostable CYP116B Self-Sufficient Cytochrome P450 Monooxygenases that Catalyze C−H Activation with a Diverse Substrate Scope

(2018) Michele Tavanti et al.   ChemCatChem

Enhancing the Catalytic Performance of a CYP116B Monooxygenase by Transdomain Combination Mutagenesis

(2018) Ren-Jie Li et al.   ChemCatChem

Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope

(2018) Joanne L. Porter et al.   ENZYME AND MICROBIAL TECHNOLOGY

Using Corn Husk Powder as a Novel Substrate to Produce a Surface Active Compound from Labrenzia aggregate KP-5

(2018) Atipan Saimmai et al.   JOURNAL OF SURFACTANTS AND DETERGENTS

Synergistic gold–copper detoxification at the core of gold biomineralisation in Cupriavidus metallidurans

(2018) L. Bütof et al.   Metallomics

Influence of inter-domain dynamics and surrounding environment flexibility on the direct electrochemistry and electrocatalysis of self-sufficient cytochrome P450 3A4-BMR chimeras

(2018) Silvia Castrignanò et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Engineering P450LaMO stereospecificity and product selectivity for selective C–H oxidation of tetralin-like alkylbenzenes

(2018) Ren-Jie Li et al.   Catalysis Science & Technology

Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis

(2017) Stephan C. Hammer et al.   SCIENCE

The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac

(2017) Jan M. Klenk et al.   Biotechnology Journal

Human Cytochrome P450 3A4 as a Biocatalyst: Effects of the Engineered Linker in Modulation of Coupling Efficiency in 3A4-BMR Chimeras

(2017) Danilo Degregorio et al.   Frontiers in Pharmacology

Conformational selectivity in cytochrome P450 redox partner interactions

(2016) Scott A. Hollingsworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular evolutionary dynamics of cytochrome P450 monooxygenases across kingdoms: Special focus on mycobacterial P450s

(2016) Mohammad Parvez et al.   Scientific Reports

Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming ofPenicillium chrysogenum

(2015) Kirsty J. McLean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations

(2014) Rita Bernhardt et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Hydrogen peroxide-independent production of α-alkenes by OleTJE P450 fatty acid decarboxylase

(2014) Yi Liu et al.   Biotechnology for Biofuels

Unusually Broad Substrate Profile of Self-Sufficient Cytochrome P450 Monooxygenase CYP116B4 fromLabrenzia aggregata

(2014) Yue-Cai Yin et al.   CHEMBIOCHEM

New Reactions and Products Resulting from Alternative Interactions between the P450 Enzyme and Redox Partners

(2014) Wei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CYP116B5: a new class VII catalytically self-sufficient cytochrome P450 fromAcinetobacter radioresistensthat enables growth on alkanes

(2014) Daniela Minerdi et al.   MOLECULAR MICROBIOLOGY

Chimeric P450 enzymes: Activity of artificial redox fusions driven by different reductases for biotechnological applications

(2013) Sheila J. Sadeghi et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Unusual Cytochrome P450 Enzymes and Reactions

(2013) F. Peter Guengerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of the Cytochrome P450cam–Putidaredoxin Complex Determined by Paramagnetic NMR Spectroscopy and Crystallography

(2013) Yoshitaka Hiruma et al.   JOURNAL OF MOLECULAR BIOLOGY

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Structural Basis for Effector Control and Redox Partner Recognition in Cytochrome P450

(2013) S. Tripathi et al.   SCIENCE

Characterization of Cupriavidus metallidurans CYP116B1 - A thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein

(2012) Ashley J. Warman et al.   FEBS Journal

Optimization of the Bacterial Cytochrome P450 BM3 System for the Production of Human Drug Metabolites

(2012) Giovanna Di Nardo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope

(2011) Aélig Robin et al.   Beilstein Journal of Organic Chemistry

P450BM3(CYP102A1): connecting the dots

(2011) Christopher J. C. Whitehouse et al.   CHEMICAL SOCIETY REVIEWS

Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system

(2011) N. Strushkevich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering cytochrome P450 monooxygenase CYP 116B3 for high dealkylation activity

(2010) Luo Liu et al.   BIOTECHNOLOGY LETTERS

LICRED: A Versatile Drop-In Vector for Rapid Generation of Redox-Self-Sufficient Cytochrome P450s

(2010) Federico Sabbadin et al.   CHEMBIOCHEM

Understanding uncoupling in the multiredox centre P450 3A4–BMR model system

(2010) Danilo Degregorio et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme

(2009) Aélig Robin et al.   CHEMICAL COMMUNICATIONS

Isolation of Rhodococcus sp. Strain ECU0066, a New Sulfide Monooxygenase-Producing Strain for Asymmetric Sulfoxidation

(2008) A.-T. Li et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY