One Ring to Rule them All? Structural and Functional Diversity in the Nuclear Pore Complex

The nuclear pore complex prevents sister chromatid recombination during replicative senescence

(2020) Paula Aguilera et al.   Nature Communications

Modulation of Cell Identity by Modification of Nuclear Pore Complexes

(2020) Mercè Gomar-Alba et al.   Frontiers in Genetics

Recruitment of an Activated Gene to the Yeast Nuclear Pore Complex Requires Sumoylation

(2020) Natasha O. Saik et al.   Frontiers in Genetics

Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis

(2020) Gaoxingyu Huang et al.   CELL RESEARCH

Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex

(2020) Yanqing Zhang et al.   CELL RESEARCH

G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD

(2020) Alyssa N. Coyne et al.   NEURON

In-cell architecture of the nuclear pore and snapshots of its turnover

(2020) Matteo Allegretti et al.   NATURE

Yeast Nup84-Nup133 complex structure details flexibility and reveals conservation of the membrane anchoring ALPS motif

(2020) Sarah A. Nordeen et al.   Nature Communications

Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination

(2019) Zhixiong Liu et al.   NEURON

SUMOylation of the nuclear pore complex basket is involved in sensing cellular stresses

(2019) Hanne Folz et al.   JOURNAL OF CELL SCIENCE

Ribosomal RNA gene repeats associate with the nuclear pore complex for maintenance after DNA damage

(2019) Chihiro Horigome et al.   PLoS Genetics

The Role of Transcription Factors and Nuclear Pore Proteins in Controlling the Spatial Organization of the Yeast Genome

(2019) Donna Garvey Brickner et al.   DEVELOPMENTAL CELL

Chromatin targeting of nuclear pore proteins induces chromatin decondensation

(2019) Terra M. Kuhn et al.   JOURNAL OF CELL BIOLOGY

Asymmetrical localization of Nup107-160 subcomplex components within the nuclear pore complex in fission yeast

(2019) Haruhiko Asakawa et al.   PLoS Genetics

Mechanisms of nuclear mRNA export: A structural perspective

(2019) Yihu Xie et al.   TRAFFIC

The Nuclear Pore Complex in Cell Type-Specific Chromatin Structure and Gene Regulation

(2019) Jiayu Sun et al.   TRENDS IN GENETICS

Core Components of the Nuclear Pore Bind Distinct States of Chromatin and Contribute to Polycomb Repression

(2019) Alejandro Gozalo et al.   MOLECULAR CELL

Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance

(2019) Nahid Iglesias et al.   MOLECULAR CELL

Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions

(2019) Bartlomiej Jan Blus et al.   Science Advances

Nuclear Pore Proteins in Regulation of Chromatin State

(2019) Terra M. Kuhn et al.   Cells

Fantastic nuclear envelope herniations and where to find them

(2018) David J. Thaller et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nuclear Pore Complexes: Global Conservation and Local Variation

(2018) Guillaume Holzer et al.   CURRENT BIOLOGY

Daughter-cell-specific modulation of nuclear pore complexes controls cell cycle entry during asymmetric division

(2018) Arun Kumar et al.   NATURE CELL BIOLOGY

Yeast and Human Nuclear Pore Complexes: Not So Similar After All

(2018) Yaron Shav-Tal et al.   TRENDS IN CELL BIOLOGY

In situ architecture of the algal nuclear pore complex

(2018) Shyamal Mosalaganti et al.   Nature Communications

Nuclear pore complexes as hubs for gene regulation

(2018) Maximiliano A. D'Angelo   Nucleus

Nuclear pore complexes as hubs for gene regulation

(2018) Maximiliano A. D'Angelo   Nucleus

From the resolution revolution to evolution: structural insights into the evolutionary relationships between vesicle coats and the nuclear pore

(2018) Martin Beck et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Integrative structure and functional anatomy of a nuclear pore complex

(2018) Seung Joong Kim et al.   NATURE

Electron microscopy of Chaetomium pom152 shows the assembly of ten-bead string

(2018) Qi Hao et al.   Cell Discovery

Moonlighting nuclear pore proteins: tissue-specific nucleoporin function in health and disease

(2018) Ramona Jühlen et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells

(2017) Tobias M. Franks et al.   GENES & DEVELOPMENT

Yeast silencing factor Sir4 and a subset of nucleoporins form a complex distinct from nuclear pore complexes

(2017) Diego L. Lapetina et al.   JOURNAL OF CELL BIOLOGY

A self-inhibitory interaction within Nup155 and membrane binding are required for nuclear pore complex formation

(2017) Paola De Magistris et al.   JOURNAL OF CELL SCIENCE

Chromatin organization at the nuclear periphery as revealed by image analysis of structured illumination microscopy data

(2017) Jindřiška Fišerová et al.   JOURNAL OF CELL SCIENCE

Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in the ciliateTetrahymena

(2017) Masaaki Iwamoto et al.   JOURNAL OF CELL SCIENCE

Metazoan Nuclear Pores Provide a Scaffold for Poised Genes and Mediate Induced Enhancer-Promoter Contacts

(2017) Pau Pascual-Garcia et al.   MOLECULAR CELL

Proteasomes tether to two distinct sites at the nuclear pore complex

(2017) Sahradha Albert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Floppy but not sloppy: Interaction mechanism of FG-nucleoporins and nuclear transport receptors

(2017) Iker Valle Aramburu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structural dynamics of the nuclear pore complex

(2017) Yusuke Sakiyama et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex

(2017) Paula Upla et al.   STRUCTURE

A short linear motif in scaffold Nup145C connects Y-complex with pre-assembled outer ring Nup82 complex

(2017) Roman Teimer et al.   Nature Communications

Structure and Function of the Nuclear Pore Complex Cytoplasmic mRNA Export Platform

(2016) Javier Fernandez-Martinez et al.   CELL

Nucleoporins and chromatin metabolism

(2016) Christopher Ptak et al.   CURRENT OPINION IN CELL BIOLOGY

Nucleoporin-mediated regulation of cell identity genes

(2016) Arkaitz Ibarra et al.   GENES & DEVELOPMENT

Global reorganization of budding yeast chromosome conformation in different physiological conditions

(2016) Elisa Dultz et al.   JOURNAL OF CELL BIOLOGY

The Multiple Faces of Disordered Nucleoporins

(2016) Edward A. Lemke   JOURNAL OF MOLECULAR BIOLOGY

Spatiotemporal dynamics of the nuclear pore complex transport barrier resolved by high-speed atomic force microscopy

(2016) Yusuke Sakiyama et al.   Nature Nanotechnology

The nuclear pore complex: understanding its function through structural insight

(2016) Martin Beck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Architecture of the symmetric core of the nuclear pore

(2016) D. H. Lin et al.   SCIENCE

Molecular architecture of the inner ring scaffold of the human nuclear pore complex

(2016) J. Kosinski et al.   SCIENCE

Visualizing the molecular sociology at the HeLa cell nuclear periphery

(2016) J. Mahamid et al.   SCIENCE

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

HOXA repression is mediated by nucleoporin Nup93 assisted by its interactors Nup188 and Nup205

(2016) Ajay S. Labade et al.   Epigenetics & Chromatin

A negative loop within the nuclear pore complex controls global chromatin organization

(2015) Manuel Breuer et al.   GENES & DEVELOPMENT

Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold

(2015) Monika Gaik et al.   JOURNAL OF CELL BIOLOGY

Impact of Nucleoporin-Mediated Chromatin Localization and Nuclear Architecture on HIV Integration Site Selection

(2015) Richard W. Wong et al.   JOURNAL OF VIROLOGY

In situ structural analysis of the human nuclear pore complex

(2015) Alexander von Appen et al.   NATURE

Linker Nups connect the nuclear pore complex inner ring with the outer ring and transport channel

(2015) Jessica Fischer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic structure of the Y complex of the nuclear pore

(2015) Kotaro Kelley et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the metazoan Nup62bulletNup58bulletNup54 nucleoporin complex

(2015) H. Chug et al.   SCIENCE

Architecture of the fungal nuclear pore inner ring complex

(2015) T. Stuwe et al.   SCIENCE

Chromatin organization at the nuclear pore favours HIV replication

(2015) Mickaël Lelek et al.   Nature Communications

Linker Nups connect the nuclear pore complex inner ring with the outer ring and transport channel

(2015) Jessica Fischer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic structure of the Y complex of the nuclear pore

(2015) Kotaro Kelley et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The multifunctional nuclear pore complex: a platform for controlling gene expression

(2014) Christopher Ptak et al.   CURRENT OPINION IN CELL BIOLOGY

Integrative Structure–Function Mapping of the Nucleoporin Nup133 Suggests a Conserved Mechanism for Membrane Anchoring of the Nuclear Pore Complex

(2014) Seung Joong Kim et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural Characterization by Cross-linking Reveals the Detailed Architecture of a Coatomer-related Heptameric Module from the Nuclear Pore Complex

(2014) Yi Shi et al.   MOLECULAR & CELLULAR PROTEOMICS

Nanoscale stiffness topography reveals structure and mechanics of the transport barrier in intact nuclear pore complexes

(2014) Aizhan Bestembayeva et al.   Nature Nanotechnology

Nucleoporin Nup98 Associates with Trx/MLL and NSL Histone-Modifying Complexes and Regulates Hox Gene Expression

(2014) Pau Pascual-Garcia et al.   Cell Reports

Integrated Structural Analysis of the Human Nuclear Pore Complex Scaffold

(2013) Khanh Huy Bui et al.   CELL

A Role for the Nucleoporin Nup170p in Chromatin Structure and Gene Silencing

(2013) David W. Van de Vosse et al.   CELL

Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines

(2013) A. Ori et al.   Molecular Systems Biology

A Conserved Role for Human Nup98 in Altering Chromatin Structure and Promoting Epigenetic Transcriptional Memory

(2013) William H. Light et al.   PLOS BIOLOGY

To the pore and through the pore: A story of mRNA export kinetics

(2012) Marlene Oeffinger et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Change in Nuclear Pore Complex Composition Regulates Cell Differentiation

(2012) Maximiliano A. D'Angelo et al.   DEVELOPMENTAL CELL

Structure–function mapping of a heptameric module in the nuclear pore complex

(2012) Javier Fernandez-Martinez et al.   JOURNAL OF CELL BIOLOGY

Nuclear Distributions of NUP62 and NUP214 Suggest Architectural Diversity and Spatial Patterning among Nuclear Pore Complexes

(2012) Yayoi Kinoshita et al.   PLoS One

Dbp5, Gle1-IP6and Nup159

(2012) Andrew W. Folkmann et al.   Nucleus

Insight into Structure and Assembly of the Nuclear Pore Complex by Utilizing the Genome of a Eukaryotic Thermophile

(2011) Stefan Amlacher et al.   CELL

Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins

(2011) Izhak Kehat et al.   JOURNAL OF CELL BIOLOGY

Membrane-coating lattice scaffolds in the nuclear pore and vesicle coats

(2011) Nina C. Leksa et al.   Nucleus

Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes

(2010) Maya Capelson et al.   CELL

Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion

(2010) Sandra Krull et al.   EMBO JOURNAL

Exceptional structural and mechanical flexibility of the nuclear pore complex

(2010) Ivan Liashkovich et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Interaction of a DNA Zip Code with the Nuclear Pore Complex Promotes H2A.Z Incorporation and INO1 Transcriptional Memory

(2010) William H. Light et al.   MOLECULAR CELL

DNA zip codes control an ancient mechanism for gene targeting to the nuclear periphery

(2010) Sara Ahmed et al.   NATURE CELL BIOLOGY

The Nuclear Pore Complex and Nuclear Transport

(2010) S. R. Wente et al.   Cold Spring Harbor Perspectives in Biology

Translocation through the nuclear pore: Kaps pave the way

(2009) Reiner Peters   BIOESSAYS

Flexible Gates: Dynamic Topologies and Functions for FG Nucleoporins in Nucleocytoplasmic Transport

(2009) Laura J. Terry et al.   EUKARYOTIC CELL

Architectural Nucleoporins Nup157/170 and Nup133 Are Structurally Related and Descend from a Second Ancestral Element

(2009) James R. R. Whittle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the Ndc1 interaction network in yeast nuclear pore complex assembly and maintenance

(2009) Evgeny Onischenko et al.   JOURNAL OF CELL BIOLOGY

Three-dimensional structure and flexibility of a membrane-coating module of the nuclear pore complex

(2009) Martin Kampmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular architecture of the Nup84–Nup145C–Sec13 edge element in the nuclear pore complex lattice

(2009) Stephen G Brohawn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex

(2009) H.-S. Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of the Scaffold Nucleoporin Nup120 Reveals a New and Unexpected Domain Architecture

(2009) Nina C. Leksa et al.   STRUCTURE

Structural Evidence for Common Ancestry of the Nuclear Pore Complex and Vesicle Coats

(2008) S. G. Brohawn et al.   SCIENCE