Article
Chemistry, Analytical
Songjiao Li, Ke Yang, Peipei Wang, Ying Liu, Dan Cheng, Longwei He
Summary: Heat stroke is a devastating pathology with high morbidity and mortality rates. Understanding the cytotoxic mechanisms of heat can help prevent or treat stroke-related diseases. The role of lysosomes in heat stroke is poorly understood due to a lack of tools, but recent studies have shown a correlation between lysosome HClO and heat stroke development. To better interpret and treat heat stroke, a reliable real-time tool for tracking HClO levels is necessary, and MB-HClO, a near-infrared probe, shows promise in rapidly detecting lysosome HClO.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Songjiao Li, Peipei Wang, Ke Yang, Ying Liu, Dan Cheng, Longwei He
Summary: In order to improve the prognosis and overall survival of hepatocellular carcinoma (HCC) patients, it is important to identify and resect it at an early stage. However, developing specific fluorescent probes to detect hypochlorous acid (HClO) in liver cells is still challenging. Therefore, the development of a new probe MBH-MT that can detect HClO in biological samples and image it in cells and tissues is of great significance for the diagnosis and treatment of HCC.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Aishan Zheng, Han Liu, Chuanhao Peng, Xiaonan Gao, Kehua Xu, Bo Tang
Summary: CVS is a mitochondria-targeting near-Infrared fluorescent probe designed for sensing and detecting HOCl with high selectivity and low detection limit. It has been successfully applied to image HOCl in mitochondria of HepG2 cells, providing a perspective method for further study of physiological and pathological functions related to HOCl.
Article
Chemistry, Analytical
Guo-Jiang Mao, Guang-Qi Gao, Wen-Pei Dong, Qian-Qian Wang, Ying-Ying Wang, Yao Li, Li Su, Guisheng Zhang
Summary: In this study, a two-photon excited near-infrared fluorescence probe (NIR-ONOO-) was developed for the detection and imaging of peroxynitrite (ONOO-), which is an important biomarker for drug-induced liver injury and other drug-induced damage. NIR-ONOO showed high selectivity, sensitivity, and performance for ONOO- detection, making it a powerful chemical tool for imaging ONOO- and assessing drug-induced hepatotoxicity.
Article
Spectroscopy
Chang Liu, Huimin Yan, Jianhong Wu, Zhiming Wang, Song He, Liancheng Zhao, Xianshun Zeng
Summary: A new near-infrared fluorescent probe Qcy-OH based on an acceptor-donor-acceptor (ADA) pi-electron system with a turn-on mechanism was developed for monitoring pH fluctuations in biological systems. The probe showed a strong pH-sensitive response and high selectivity for intracellular lysosomes, enabling the tracking of lysosomal pH changes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Qian-Qian Wang, Ying-Ying Wang, Yao Li, Shu-Yu Zhang, Xin-Yu Guo, Wen-Ke Zha, Wen-Jun Li, Guo-Jiang Mao
Summary: A lysosome-targetable fluorescent probe (Lyso-R-HClO) for monitoring hypochlorous acid in lysosomes was developed. The probe showed high selectivity and sensitivity to hypochlorous acid and was successfully used to image lysosomal hypochlorous acid in bacteria-infected macrophages.
ANALYTICAL SCIENCES
(2022)
Article
Chemistry, Analytical
Wenjie Gao, Yanyan Ma, Yongyuan Liu, Shihan Ma, Weiying Lin
Summary: In this study, a near-infrared fluorescent probe CyClOP was developed for rapid detection of endogenous HClO, showing advantages of fast response, good selectivity, and deep penetration. The probe successfully captured the fluctuation of endogenous HClO in living cells during infection and injury conditions, providing a reliable tool for monitoring endogenous HClO and potential for future research in HClO-related biology and pathology.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Meng He, Miantai Ye, Bo Li, Tsunghsueh Wu, Chunfeng Lu, Pan Liu, Huiyue Li, Xingyu Zhou, Yanying Wang, Tao Liang, Haiyan Li, Chunya Li
Summary: In this study, a near-infrared fluorescent probe, TJM, was developed for selective and sensitive bioimaging of HClO. TJM exhibited excellent selectivity, high sensitivity, and low detection limit, making it suitable for imaging endogenous HClO in biological systems.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Songjiao Li, Peipei Wang, Ying Liu, Ke Yang, Rongbin Zhong, Dan Cheng, Longwei He
Summary: Idiopathic pulmonary fibrosis (IPF) is a fatal chronic inflammatory disease with challenges in diagnosis and early treatment. Hypochlorous acid (HClO) has been proposed as a potential diagnostic tool for inflammation, including pulmonary fibrosis. A new probe called NIR-PTZ-HClO was developed for detecting HClO levels in cells and mice models. This advanced probe demonstrated high sensitivity, selectivity, and quick detection of HClO. It has the potential to improve the diagnosis of lung fibrosis and enhance treatment efficacy.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Liu Yang, Yan Liu, Mingli Yue, Ping Li, Yulong Liu, Fei Ye, Ying Fu
Summary: In this study, a new chemosensor MMN was designed and synthesized for monitoring pH and isoxaflutole. The results showed that MMN exhibited excellent stability and a clear fluorescence response to pH changes. It could selectively locate lysosomes in live cells and successfully detect H+ on test papers. Moreover, MMN specifically recognized isoxaflutole at a low detection limit. These findings suggest that MMN could be a potential chemosensor for pH and isoxaflutole detection in real samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Bin Feng, Yeshuo Ma, Fan Zheng, Xueyan Huang, Xueping Feng, Kexiang Zhang, Li Liu, Fei Chen, Wenbin Zeng
Summary: A lysosome-targeted pH-activatable probe Lyso-QL was developed to monitor autophagy progression in living cells. By evaluating the pH changes in acidic compartments, the real-time monitoring of autophagic flux was achieved. The study revealed the modulation of tamoxifen on autophagic levels in estrogen receptor-negative cancer cells and the elevated hepatic autophagy in mice during acetaminophen-induced liver injury. The probe Lyso-QL provides mechanistic insights into autophagy and can be used to evaluate the activities of autophagy modulators.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Qiuchen Liu, Chang Liu, Xiaojie Jiao, Songtao Cai, Song He, Liancheng Zhao, Xianshun Zeng, Tianhui Wang
Summary: The paper introduces a novel lysosome-targeting NIR xanthene-benzothiozolium dye which is highly sensitive for monitoring Cys levels and can be targeted in living cells. This probe does not require proton participation, making it useful for studying lysosome function and interpreting the role of lysosomal Cys in living-cell imaging.
Article
Chemistry, Multidisciplinary
Wei Hu, Taotao Qiang, Chenchen Li, Longfang Ren, Fei Cheng, Baoshuai Wang, Mingli Li, Xinjian Song, Tony D. James
Summary: Small-molecule NIR imaging is a popular technique for tracking biological species and events due to its advantages such as deep tissue penetration, low autofluorescence, non-invasive visualization, and simple operation. However, the small Stokes shift of most NIR dyes often leads to low signal-to-noise ratio and self-quenching. In this research, a NIR-based fluorescent probe was developed for hypochlorous acid detection, which successfully addressed the issue of crosstalk between excitation and emission spectra. Imaging studies demonstrated the probe's potential for endogenous HOCl detection and imaging in living cells.
Article
Chemistry, Analytical
Shengyi Gong, Zhoupeng Zheng, Xiaogang Guan, Shumin Feng, Guoqiang Feng
Summary: A novel near-infrared mitochondria-targetable fluorescence probe MI-H2S was developed for the rapid and selective detection of H2S, with high contrast imaging ability in living systems and great potential in studying the role of H2S in inflammation. This probe can be applied effectively for visualization and study of H2S in mitochondria and in vivo.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Guanwen Fan, Nannan Wang, Jian Zhang, Xin Ji, Shuchun Qin, Yuanfang Tao, Weili Zhao
Summary: This research developed a BODIPY-based probe for the selective and sensitive response of hypochlorous acid. The probe can detect hypochlorous acid at high concentrations quickly, and it can diagnose and visualize drug-induced liver injury.
Article
Spectroscopy
Zh. E. Ozbekova, A. A. Abdyldaev, A. A. Kulmyrzaev
Summary: This study compared two drying methods for cow and yak muscles, finding that freeze drying caused less discoloration. Additionally, analysis of fluorescence spectra allowed for accurate prediction of chemical composition and color characteristics of the muscles.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Leo Mandic, Ivan Ljubic, Iva Dzeba
Summary: In this study, a combined experimental and computational approach was used to investigate the photoexcitation and photodegradation mechanisms of Doxazosin (DOX). The results provide valuable insights into the primary events following the photoexcitation of DOX and its potential applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Xiufeng Wang, Yao Jin, Wenhui Ai, Siqi Wang, Zhiqing Zhang, Ting Zhou, Fang Wang, Guodong Zhang
Summary: This study successfully synthesized near infrared fluorescence Ag2S quantum dots (QDs) and developed a dual-mode sensor for sulfide anion using the excellent oxidase-like characteristics of manganese dioxide (MnO2) nanosheets. The sensor showed a wider detection range, higher sensitivity, and shorter reaction time, making it suitable for highly selective detection of sulfide in different concentration ranges.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Yafei Li, Yanming Ma, Chuantao Zheng, Di Yu, Lien Hu, Shuo Yang, Fang Song, Yadan Li, Shuanghai Liu, Zhanrui Zhang, Yu Zhang, Yiding Wang, Frank K. Tittel
Summary: To effectively monitor gas explosion and coal spontaneous combustion in coal mine, an intrinsically safe and explosion-proof dual-gas sensor system was developed for methane (CH4) and carbon monoxide (CO) measurement. The system achieved different measurement ranges using laser scanning and gas cells, and improved stability and accuracy through gas pre-treatment and temperature compensation algorithm.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Pei-Rong Chen, Li-Kang Chu
Summary: In this study, the hydrates of glyoxal were investigated using infrared absorption spectrometry. The results showed that at low concentrations, glyoxal mainly exists as monomeric dihydrate. These findings provide suitable detection windows for further research on the roles of glyoxal and its hydrates in atmospheric and aerosol chemistry, as well as the relevant reaction kinetics.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Nichole O'Neill, Thamires A. Lima, Fabio Furlan Ferreira, Nicolas J. Alvarez, Reinhard Schweitzer-Stenner
Summary: This study determines the main fibril axis of GHG gel-forming fibrils using various techniques and compares the results with simulated data. The analysis suggests that the hydrophobic xz-surfaces of GHG fibrils could be a good target for the adsorption of hydrophobic drugs.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Mengyuan Liu, Hanchuang Zhu, Yikun Fang, Caiyun Liu, Xinke Li, Xiaohui Zhang, Lixue Ma, Kun Wang, Miaohui Yu, Wenlong Sheng, Baocun Zhu
Summary: ABHS is an efficient fluorescent probe that can accurately and sensitively detect Al3+ with strong resistance to interference. It also demonstrates excellent detection and imaging capabilities in complex real samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Ahmed S. El-Shafie, Evana Rahman, Yasser Gadelhak, Rehab Mahmoud, Marwa El-Azary
Summary: The recycling of waste mandarin peels into biochar (MRBC) has been used as a high performance and cost-effective adsorbent for treating polluted wastewater effluents. Batch adsorption studies were conducted to analyze the adsorption competency of MRBC on two dyes, methylene blue (MB) and basic fuchsin (BF), either in individual solutions or binary combinations. The results showed that MRBC was capable of effectively removing a high percentage of both dyes. However, the adsorption capacity decreased when the dyes were combined. The cost estimation of MRBC production and wastewater treatment indicated that both were relatively low.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Anindita Bhatta, Jahnabi Upadhyaya, Dipak Chamlagai, Lincoln Dkhar, Pynskhemborlang T. Phanrang, Mohan Rao Kollipara, Sivaprasad Mitra
Summary: Derivatives of thiazole-pyrazole fused benzo-coumarin compounds were synthesized and their photophysical properties were investigated. The synthesized coumarin compounds showed potential as therapeutic agents for Alzheimer's disease, inhibiting acetylcholinesterase activity. The presence of human serum albumin was found to affect the inhibition activity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Yongwei Duan, Quancheng Liu, Yiju Zhu, Qi Zhang, Xiaohui Duan, Hu Deng, Liping Shang
Summary: In this study, the phase transition of CL-20 was observed using terahertz spectroscopy, and quantum chemical calculations were employed to analyze the vibrations. The results indicated changes in the vibrations of CL-20 before and after phase transition.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Yuefeng Gao, Sai Xu, Baojiu Chen
Summary: This study synthesized Cs2NaInCl6 nanocrystals co-doped with Sb3+ and Tb3+ ions as probes for copper ions detection in lubricating oil. The introduction of Sb3+ effectively reduced the band gap of the host material and enabled energy transfer pathway for Tb3+ emission. The doped Tb3+ ions resulted in the suppression of emission due to electron transfer. The Cs2NaInCl6: 2.5 %Sb3+, 40 %Tb3+ NCs exhibited superior sensitivity and selectivity for copper ions detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Yu Liu, Yue Zhang, Changyao Liu, Ce Wang, Baocai Xu, Li Zhao
Summary: A highly sensitive detection platform for heparin was developed using a cationic fluorescent dye (cresyl violet acetate) as a fluorescence probe. The platform demonstrated high selectivity towards heparin and achieved detection in both HEPES solution and serum.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Lopamudra Roy, Nivedita Pan, Susmita Mondal, Ria Ghosh, Md. Nur Hasan, Neha Bhattacharyya, Soumendra Singh, Kallol Bhattacharyya, Arpita Chattopadhyay, Samir Kumar Pal
Summary: The study focuses on the interaction between reactive oxygen species (ROS) and a spectroscopic probe called Rose Bengal (RB), encapsulated in nanoscopic sodium dodecyl sulphate (SDS) micelles and entrapped in microscopic nylon 66 solid matrix. The research demonstrates efficient interaction between ROS and RB-SDS, and investigates the mechanism of hydroxyl radicals generation. Based on these findings, a prototype device utilizing RB embedded in a nylon thin film for quantification of ROS in extracellular fluids and food materials was developed.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Xiaosong Sun, Qihao Cui, Wenyue Dong, Qian Duan, Teng Fei
Summary: Conjugated porous polymers (CPPs) are promising sensing materials and their application in aqueous media is limited. In this study, we synthesized CPPs with porous structure and prepared nanoparticles, enabling efficient photoluminescence sensing of nitroaromatic explosives in aqueous phase.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Maria Cristina Caggiani, Germana Barone, Paolo Mazzoleni
Summary: Raman spectroscopy is commonly used for studying glassy materials in cultural heritage, but it is more difficult to interpret the spectra and apply the technique with portable instruments. In contrast, diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) can be used in archaeometric investigations as it is portable and non-invasive. However, there is limited application of this technique to historical glasses. This exploratory work demonstrates the potential of DRIFTS, in combination with portable X-ray Fluorescence (pXRF) and EDS microanalyses, for studying the composition and alteration of glass samples in cultural heritage.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)