MicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodium channels in spinal cord

Sensory neuron–derived NaV1.7 contributes to dorsal horn neuron excitability

(2020) Sascha R. A. Alles et al.   Science Advances

Triptolide Suppressed the Microglia Activation to Improve Spinal Cord Injury through miR-96/IKKβ/NF-κB Pathway

(2019) Yang Huang et al.   SPINE

Sensational MicroRNAs: Neurosensory Roles of the MicroRNA-183 Family

(2019) Samantha A. Banks et al.   MOLECULAR NEUROBIOLOGY

Adiponectin regulates thermal nociception in a mouse model of neuropathic pain

(2018) L. Sun et al.   BRITISH JOURNAL OF ANAESTHESIA

Voltage-gated Sodium Channels Regulating Action Potential Generation in Itch-, Nociceptive-, and Low-Threshold Mechanosensitive Cutaneous C-fibers

(2018) Danica Jurcakova et al.   MOLECULAR PHARMACOLOGY

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Antisense oligonucleotides selectively suppress target RNA in nociceptive neurons of the pain system and can ameliorate mechanical pain

(2018) Apoorva Mohan et al.   PAIN

Efficacy of the Nav1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy

(2018) Aoibhinn McDonnell et al.   PAIN

The Novel Activity of Carbamazepine as an Activation Modulator Extends from NaV1.7 Mutations to the NaV1.8-S242T Mutant Channel from a Patient with Painful Diabetic Neuropathy

(2018) Chongyang Han et al.   MOLECULAR PHARMACOLOGY

Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn

(2017) Andrew J Todd   Molecular Pain

miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes

(2017) Changgeng Peng et al.   SCIENCE

MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain

(2017) Atsushi Sakai et al.   Nature Communications

Development of putative inhibitory neurons in the embryonic and postnatal mouse superficial spinal dorsal horn

(2016) Anita Balázs et al.   Brain Structure & Function

Activation of Direct and Indirect Pathway Medium Spiny Neurons Drives Distinct Brain-wide Responses

(2016) Hyun Joo Lee et al.   NEURON

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

(2016) Aristos J. Alexandrou et al.   PLoS One

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat

(2015) W. Rahman et al.   NEUROSCIENCE

Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

(2015) Sharan K. Bagal et al.   ACS Medicinal Chemistry Letters

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathy

(2014) Jianying Huang et al.   BRAIN

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Transmitting Pain and Itch Messages: A Contemporary View of the Spinal Cord Circuits that Generate Gate Control

(2014) João Braz et al.   NEURON

Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1

(2014) Chul-Kyu Park et al.   NEURON

A de novo gain-of-function mutation in SCN11A causes loss of pain perception

(2013) Enrico Leipold et al.   NATURE GENETICS

Intrathecal miR-96 Inhibits Nav1.3 Expression and Alleviates Neuropathic Pain in Rat Following Chronic Construction Injury

(2013) Hong-Ping Chen et al.   NEUROCHEMICAL RESEARCH

Neurological perspectives on voltage-gated sodium channels

(2012) N. Eijkelkamp et al.   BRAIN

A Unilateral Negative Feedback Loop Between miR-200 microRNAs and Sox2/E2F3 Controls Neural Progenitor Cell-Cycle Exit and Differentiation

(2012) C. Peng et al.   JOURNAL OF NEUROSCIENCE

Expression of Nav1.7 in DRG Neurons Extends from Peripheral Terminals in the Skin to Central Preterminal Branches and Terminals in the Dorsal Horn

(2012) Joel A Black et al.   Molecular Pain

Gain-of-function Nav1.8 mutations in painful neuropathy

(2012) C. G. Faber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

(2012) Michael S. Minett et al.   Nature Communications

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

(2011) Catharina G. Faber et al.   ANNALS OF NEUROLOGY

Inhibitory neurones of the spinal substantia gelatinosa mediate interaction of signals from primary afferents

(2010) Jihong Zheng et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

SCN2A mutation associated with neonatal epilepsy, late-onset episodic ataxia, myoclonus, and pain

(2010) Y. Liao et al.   NEUROLOGY

Chloride regulation in the pain pathway

(2009) Theodore J. Price et al.   BRAIN RESEARCH REVIEWS

Innocuous, Not Noxious, Input Activates PKC  Interneurons of the Spinal Dorsal Horn via Myelinated Afferent Fibers

(2008) S. Neumann et al.   JOURNAL OF NEUROSCIENCE

Inflammation-Induced Shift in the Valence of Spinal GABA-A Receptor–Mediated Modulation of Nociception in the Adult Rat

(2008) Vanessa C.Z. Anseloni et al.   JOURNAL OF PAIN