Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10

Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis

(2020) Nicola E. Owen et al.   EBioMedicine

Advances in the molecular regulation of endothelial BMP9 signalling complexes and implications for cardiovascular disease

(2019) Jennifer H. Wood et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension

(2019) Peiran Yang et al.   BRITISH JOURNAL OF PHARMACOLOGY

BMP 9 is a paracrine factor controlling liver sinusoidal endothelial cell fenestration and protecting from hepatic fibrosis

(2019) Agnès Desroches‐Castan et al.   HEPATOLOGY

The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders

(2019) Eric Marsault et al.   Annals of the New York Academy of Sciences

Apelin promotes hepatic fibrosis through ERK signaling in LX-2 cells

(2019) Ying Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand

(2019) Cai Read et al.   PHARMACOLOGICAL REVIEWS

Diagnostic Significance of Plasma Levels of Novel Adipokines in Patients With Symptomatic Intra- and Extracranial Atherosclerotic Stenosis

(2019) Fang Yu et al.   Frontiers in Neurology

Roles of the Hepatic Endocannabinoid and Apelin Systems in the Pathogenesis of Liver Fibrosis

(2019) Pedro Melgar-Lesmes et al.   Cells

Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans

(2019) Duuamene Nyimanu et al.   Scientific Reports

Fc-apelin fusion protein attenuates lipopolysaccharide-induced liver injury in mice

(2018) Huifen Zhou et al.   Scientific Reports

Apelin/APJ system: A key therapeutic target for liver disease

(2017) Shuang-Yu Lv et al.   Oncotarget

[Pyr1]Apelin-13(1–12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13

(2017) Peiran Yang et al.   Frontiers in Neuroscience

The Role of the Apelin/APJ System in the Regulation of Liver Disease

(2017) Xinrui Lv et al.   Frontiers in Pharmacology

The apelin–APJ axis: A novel potential therapeutic target for organ fibrosis

(2016) Shifang Huang et al.   CLINICA CHIMICA ACTA

Clinical Implications of the Serum Apelin Level on Portal Hypertension and Prognosis of Liver Cirrhosis

(2016) Yoo Li Lim et al.   Gut and Liver

Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist

(2015) A. L. Brame et al.   HYPERTENSION

The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells

(2015) He Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis

(2015) Maria Kalafateli   WORLD JOURNAL OF GASTROENTEROLOGY

Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma

(2013) Eugene Y. Zhen et al.   ANALYTICAL BIOCHEMISTRY

Apelin Ameliorates TNF-α-Induced Reduction of Glycogen Synthesis in the Hepatocytes through G Protein-Coupled Receptor APJ

(2013) Jiaojiao Chu et al.   PLoS One

BMPs go for apelin to regulate angiogenesis. Focus on “Inhibition of apelin expression by BMP signaling in endothelial cells”

(2012) Delphine Ciais et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of apelin expression by BMP signaling in endothelial cells

(2012) Odette Poirier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Apelin, Plasmatic Osmolality and Hypotension in Dialyzed Patients

(2012) Valeria Cernaro et al.   BLOOD PURIFICATION

Enhanced expressions of apelin on proliferative hepatic arterial capillaries in human cirrhotic liver

(2012) Hiroaki Yokomori et al.   HEPATOLOGY RESEARCH

Apelin is a marker of the progression of liver fibrosis and portal hypertension in patients with biliary atresia

(2012) Wei Chen et al.   PEDIATRIC SURGERY INTERNATIONAL

Hypoxia and proinflammatory factors upregulate apelin receptor expression in human stellate cells and hepatocytes

(2011) P. Melgar-Lesmes et al.   GUT

Disruption of PPARγ/β-catenin–mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

(2011) Tero-Pekka Alastalo et al.   JOURNAL OF CLINICAL INVESTIGATION

Apelin Mediates the Induction of Profibrogenic Genes in Human Hepatic Stellate Cells

(2010) Pedro Melgar-Lesmes et al.   ENDOCRINOLOGY

Overexpression of apelin receptor (APJ/AGTRL1) on hepatic stellate cells and sinusoidal angiogenesis in human cirrhotic liver

(2010) Hiroaki Yokomori et al.   JOURNAL OF GASTROENTEROLOGY

Plasma apelin levels in subjects with nonalcoholic fatty liver disease

(2010) Cemal Nuri Ercin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Serum levels of vaspin, obestatin, and apelin-36 in patients with nonalcoholic fatty liver disease

(2010) Bilge Aktas et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

[Pyr 1 ]Apelin-13 Identified as the Predominant Apelin Isoform in the Human Heart

(2009) Janet J. Maguire et al.   HYPERTENSION

The hepatic apelin system: A new therapeutic target for liver disease

(2008) Alessandro Principe et al.   HEPATOLOGY