Current and emerging roles of Cockayne syndrome group B (CSB) protein

Mitophagy and DNA damage signaling in human aging

(2020) Mansi Babbar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cockayne syndrome group A and B proteins function in rRNA transcription through nucleolin regulation

(2020) Mustafa N Okur et al.   NUCLEIC ACIDS RESEARCH

Defective transcription of ATF3 responsive genes, a marker for Cockayne Syndrome

(2020) Alexey Epanchintsev et al.   Scientific Reports

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

(2020) Yuka Nakazawa et al.   CELL

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

(2020) Ana Tufegdžić Vidaković et al.   CELL

The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II

(2020) Yana van der Weegen et al.   Nature Communications

A C. elegans model for neurodegeneration in Cockayne syndrome

(2020) Amanda F C Lopes et al.   NUCLEIC ACIDS RESEARCH

Molecular basis of transcriptional pausing, stalling, and transcription-coupled repair initiation

(2020) Juntaek Oh et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

(2019) Elizaveta E Alemasova et al.   NUCLEIC ACIDS RESEARCH

FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER

(2019) Franziska Wienholz et al.   NUCLEIC ACIDS RESEARCH

Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein

(2019) Tomio S Takahashi et al.   NUCLEIC ACIDS RESEARCH

Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway

(2019) Elwood A. Mullins et al.   TRENDS IN BIOCHEMICAL SCIENCES

Non-canonical DNA/RNA structures during Transcription-Coupled Double-Strand Break Repair: Roadblocks or Bona fide repair intermediates?

(2019) Nadine Puget et al.   DNA REPAIR

Transcription-Coupled Repair: From Cells to Single Molecules and Back Again

(2019) T.R. Strick et al.   JOURNAL OF MOLECULAR BIOLOGY

Cockayne syndrome group B deficiency reduces H3K9me3 chromatin remodeler SETDB1 and exacerbates cellular aging

(2019) Jong-Hyuk Lee et al.   NUCLEIC ACIDS RESEARCH

DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging

(2019) Vinod Tiwari et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The DNA damage response to transcription stress

(2019) Hannes Lans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection

(2019) Nicole L Batenburg et al.   NUCLEIC ACIDS RESEARCH

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

(2019) Evandro F. Fang et al.   Nature Communications

The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair

(2018) Aleem Syed et al.   Annual Review of Biochemistry

Efficient UV repair requires disengagement of the CSB winged helix domain from the CSB ATPase domain

(2018) Nicole L. Batenburg et al.   DNA REPAIR

Functional and clinical relevance of novel mutations in a large cohort of patients with Cockayne syndrome

(2018) Nadege Calmels et al.   JOURNAL OF MEDICAL GENETICS

The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage

(2018) Hervé Menoni et al.   NUCLEIC ACIDS RESEARCH

The Cellular Response to Transcription-Blocking DNA Damage

(2018) Lea H. Gregersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Loss of Proteostasis Is a Pathomechanism in Cockayne Syndrome

(2018) Marius Costel Alupei et al.   Cell Reports

DNA scanning by base excision repair enzymes and implications for pathway coordination

(2018) Michael J. Howard et al.   DNA REPAIR

Towards Understanding Genomic Instability, Mitochondrial Dysfunction and Aging

(2018) Nima B Fakouri et al.   FEBS Journal

Poly(ADP-ribose) polymerase 1 (PARP1) promotes oxidative stress–induced association of Cockayne syndrome group B protein with chromatin

(2018) Erica L Boetefuer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Intranuclear Distribution of the Cockayne Syndrome Proteins

(2018) Teruaki Iyama et al.   Scientific Reports

PARP inhibition protects mitochondria and reduces ROS production via PARP-1-ATF4-MKP-1-MAPK retrograde pathway

(2017) Eniko Hocsak et al.   FREE RADICAL BIOLOGY AND MEDICINE

DNA damage related crosstalk between the nucleus and mitochondria

(2017) Mohammad Saki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cockayne’s Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation

(2017) Alexey Epanchintsev et al.   MOLECULAR CELL

Repair of oxidatively induced DNA damage by DNA glycosylases: Mechanisms of action, substrate specificities and excision kinetics

(2017) Miral Dizdaroglu et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

(2017) Jun Xu et al.   NATURE

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB

(2017) Ju Yeon Lee et al.   NUCLEIC ACIDS RESEARCH

ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice

(2017) Nicole L. Batenburg et al.   Nature Communications

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

Elements That Regulate the DNA Damage Response of Proteins Defective in Cockayne Syndrome

(2016) Teruaki Iyama et al.   JOURNAL OF MOLECULAR BIOLOGY

Nuclear DNA damage signalling to mitochondria in ageing

(2016) Evandro Fei Fang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nucleotide Excision Repair: Finely Tuned Molecular Orchestra of Early Pre-incision Events

(2016) Qianzheng Zhu et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA

(2016) Morten Scheibye-Knudsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of parkin rescues the defective mitochondrial phenotype and the increased apoptosis of Cockayne Syndrome A cells

(2016) Barbara Pascucci et al.   Oncotarget

UV-induced proteolysis of RNA polymerase II is mediated by VCP/p97 segregase and timely orchestration by Cockayne syndrome B protein

(2016) Jinshan He et al.   Oncotarget

Interaction between the Cockayne syndrome B and p53 proteins: implications for aging

(2016) Mattia Frontini et al.   Aging-US

A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging

(2016) Morten Scheibye-Knudsen et al.   Aging-US

SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia

(2015) Hyun-Yoo Joo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation

(2015) N. L. Batenburg et al.   EMBO JOURNAL

The Cockayne Syndrome Natural History (CoSyNH) study: clinical findings in 102 individuals and recommendations for care

(2015) Brian T. Wilson et al.   GENETICS IN MEDICINE

Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light

(2015) Karin C. Calaza et al.   NEUROBIOLOGY OF AGING

The CSB chromatin remodeler and CTCF architectural protein cooperate in response to oxidative stress

(2015) Robert J. Lake et al.   NUCLEIC ACIDS RESEARCH

Nationwide survey of Cockayne syndrome in Japan: Incidence, clinical course and prognosis

(2015) Masaya Kubota et al.   PEDIATRICS INTERNATIONAL

DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination

(2015) Leizhen Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders

(2014) Morten Scheibye-Knudsen et al.   Autophagy

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

Cockayne syndrome protein A is a transcription factor of RNA polymerase I and stimulates ribosomal biogenesis and growth

(2014) Sylvia Koch et al.   CELL CYCLE

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity

(2014) Maria D. Aamann et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Understanding nucleotide excision repair and its roles in cancer and ageing

(2014) Jurgen A. Marteijn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function

(2014) Bartosz Szczesny et al.   NUCLEIC ACIDS RESEARCH

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing

(2014) Teruaki Iyama et al.   NUCLEIC ACIDS RESEARCH

Identification of Two Missense Mutations of ERCC6 in Three Chinese Sisters with Cockayne Syndrome by Whole Exome Sequencing

(2014) Shanshan Yu et al.   PLoS One

Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease

(2014) Yuming Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Sequence-Specific Transcription Factor c-Jun Targets Cockayne Syndrome Protein B to Regulate Transcription and Chromatin Structure

(2014) Robert J. Lake et al.   PLoS Genetics

Malfunction of Nuclease ERCC1-XPF Results in Diverse Clinical Manifestations and Causes Cockayne Syndrome, Xeroderma Pigmentosum, and Fanconi Anemia

(2013) Kazuya Kashiyama et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human Apurinic/Apyrimidinic Endonuclease 1

(2013) Mengxia Li et al.   ANTIOXIDANTS & REDOX SIGNALING

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Blinded by the UV light: How the focus on transcription-coupled NER has distracted from understanding the mechanisms of Cockayne syndrome neurologic disease

(2013) P.J. Brooks   DNA REPAIR

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

(2013) L. Serrano et al.   GENES & DEVELOPMENT

Multiple interaction partners for Cockayne syndrome proteins: Implications for genome and transcriptome maintenance

(2013) Maria D. Aamann et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cockayne syndrome pathogenesis: Lessons from mouse models

(2013) Dick Jaarsma et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cockayne syndrome: The expanding clinical and mutational spectrum

(2013) Vincent Laugel   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial deficiency in Cockayne syndrome

(2013) Morten Scheibye-Knudsen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress

(2013) U. Kristensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Transcription-Coupled Excision Repair

(2013) W. Vermeulen et al.   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

ATP-Dependent Chromatin Remodeling by Cockayne Syndrome Protein B and NAP1-Like Histone Chaperones Is Required for Efficient Transcription-Coupled DNA Repair

(2013) Iltaeg Cho et al.   PLoS Genetics

An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress

(2012) Barbara Pascucci et al.   AGING CELL

Human mitochondrial RNA polymerase: Structure–function, mechanism and inhibition

(2012) Jamie J. Arnold et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk

(2012) B Karahalil et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Genome-wide Studies of CCCTC-binding Factor (CTCF) and Cohesin Provide Insight into Chromatin Structure and Regulation: FIGURE 1.

(2012) Bum-Kyu Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

(2012) Morten Scheibye-Knudsen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair

(2012) Yuka Nakazawa et al.   NATURE GENETICS

Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair

(2012) Xue Zhang et al.   NATURE GENETICS

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

(2012) Petra Schwertman et al.   NATURE GENETICS

Human Cockayne syndrome B protein reciprocally communicates with mitochondrial proteins and promotes transcriptional elongation

(2012) Brian R. Berquist et al.   NUCLEIC ACIDS RESEARCH

Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis

(2012) Milica Enoiu et al.   NUCLEIC ACIDS RESEARCH

Metabolic regulation by SIRT3: implications for tumorigenesis

(2012) Lydia W.S. Finley et al.   TRENDS IN MOLECULAR MEDICINE

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein

(2011) Leizhen Wei et al.   CANCER SCIENCE

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

(2011) Eric S. Fischer et al.   CELL

Cockayne Syndrome B protein (CSB): Linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions

(2011) Mattia Frontini et al.   CELL CYCLE

CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination

(2011) Paolo Latini et al.   CELL CYCLE

Structure and function of WD40 domain proteins

(2011) Chao Xu et al.   Protein & Cell

Overview of Base Excision Repair Biochemistry

(2011) Yun-Jeong Kim et al.   Current Molecular Pharmacology

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane

(2010) Maria D. Aamann et al.   FASEB JOURNAL

Discovery and Characterization of DNA Excision Repair Pathways: the Work of Philip Courtland Hanawalt

(2010) Nicole Kresge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging

(2010) York Kamenisch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Ubiquitin-Binding Domain in Cockayne Syndrome B Required for Transcription-Coupled Nucleotide Excision Repair

(2010) Roy Anindya et al.   MOLECULAR CELL

UV-Induced Association of the CSB Remodeling Protein with Chromatin Requires ATP-Dependent Relief of N-Terminal Autorepression

(2010) Robert J. Lake et al.   MOLECULAR CELL

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Cockayne Syndrome Group B Protein Stimulates Repair of Formamidopyrimidines by NEIL1 DNA Glycosylase

(2009) Meltem Muftuoglu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Localization of PARP-1 Requires Interaction with Mitofilin and Is Involved in the Maintenance of Mitochondrial DNA Integrity

(2009) Marianna N. Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleic Acid Binding Activity of Human Cockayne Syndrome B Protein and Identification of Ca2+ as a Novel Metal Cofactor

(2009) Brian R. Berquist et al.   JOURNAL OF MOLECULAR BIOLOGY

A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage

(2009) T. Nardo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epigenetics of rRNA Genes: From Molecular to Chromosome Biology

(2008) Brian McStay et al.   Annual Review of Cell and Developmental Biology

Base excision repair of oxidative DNA damage and association with cancer and aging

(2008) S. Maynard et al.   CARCINOGENESIS

A Metabolic Throttle Regulates the Epigenetic State of rDNA

(2008) Ingrid Grummt et al.   CELL

Mitochondrial DNA, base excision repair and neurodegeneration

(2008) Nadja C. de Souza-Pinto et al.   DNA REPAIR

Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy

(2008) Wim J. Kleijer et al.   DNA REPAIR

CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response

(2008) Silvia Filippi et al.   EMBO JOURNAL

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

(2008) Longchuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical implications of the basic defects in Cockayne syndrome and xeroderma pigmentosum and the DNA lesions responsible for cancer, neurodegeneration and aging

(2008) J.E. Cleaver et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

(2008) Tinna Stevnsner et al.   MECHANISMS OF AGEING AND DEVELOPMENT