Design, Synthesis, and In Silico Multitarget Pharmacological Simulations of Acid Bioisosteres with a Validated In Vivo Antihyperglycemic Effect

Thermodynamics and Kinetics of Drug-Target Binding by Molecular Simulation

(2020) Sergio Decherchi et al.   CHEMICAL REVIEWS

Novel inhibitors of human glucose-6-phosphate dehydrogenase (HsG6PD) affect the activity and stability of the protein

(2020) Edson Jiovany Ramírez-Nava et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

3D Modeling of Tumor Necrosis Factor Receptor and Tumor Necrosis Factor-Bound Receptor Systems

(2019) Urmi Roy   Molecular Informatics

OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules

(2019) Katarina Roos et al.   Journal of Chemical Theory and Computation

Comparison of Data Fusion Methods as Consensus Scores for Ensemble Docking

(2019) Dávid Bajusz et al.   MOLECULES

Quantitative Structure Activity Relationship Studies and Molecular Dynamics Simulations of 2-(Aryloxyacetyl)cyclohexane-1,3-Diones Derivatives as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

(2019) Ying Fu et al.   Frontiers in Chemistry

Design, Synthesis, Antihyperglycemic Studies, and Docking Simulations of Benzimidazole-Thiazolidinedione Hybrids

(2019) Abraham Gutierréz-Hernández et al.   Journal of Chemistry

The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation

(2018) Jun He et al.   ACTA PHARMACOLOGICA SINICA

Computer-aided drug design and virtual screening of targeted combinatorial libraries of mixed-ligand transition metal complexes of 2-butanone thiosemicarbazone

(2018) Tahmeena Khan et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Ursolic acid derivatives as potential antidiabetic agents: In vitro , in vivo , and in silico studies

(2018) Ricardo Guzmán-Ávila et al.   DRUG DEVELOPMENT RESEARCH

Cladosporamide A, a new protein tyrosine phosphatase 1B inhibitor, produced by an Indonesian marine sponge-derived Cladosporium sp.

(2018) Henki Rotinsulu et al.   Journal of Natural Medicines

Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids

(2018) Blanca Colín-Lozano et al.   MOLECULES

Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds

(2018) Miguel Ángel Herrera-Rueda et al.   BIOMEDICINE & PHARMACOTHERAPY

Synthesis and evaluation of thiazolidine-2,4-dione/benzazole derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B): Antihyperglycemic activity with molecular docking study

(2018) Sergio Hidalgo-Figueroa et al.   BIOMEDICINE & PHARMACOTHERAPY

An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications

(2018) Rosanna Maccari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Comparison of fenofibrate and pioglitazone effects on patients with nonalcoholic fatty liver disease

(2017) Malek Yaghoubi et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts—Computational and Experimental Investigations

(2017) Sodik Numonov et al.   MOLECULES

Rosiglitazone promotes cardiac hypertrophy and alters chromatin remodeling in isolated cardiomyocytes

(2017) Lama Fawaz Pharaon et al.   TOXICOLOGY LETTERS

Synthesis and In Vitro AMPK Activation of Cycloalkyl/Alkarylbiguanides with Robust In Vivo Antihyperglycemic Action

(2017) Erika Gutierrez-Lara et al.   Journal of Chemistry

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10

(2015) Francesc X. Ruiz et al.   ChemMedChem

PTP1B inhibition suggests a therapeutic strategy for Rett syndrome

(2015) Navasona Krishnan et al.   JOURNAL OF CLINICAL INVESTIGATION

Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient-Centered Approach: Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes

(2014) Silvio E. Inzucchi et al.   DIABETES CARE

Targeting Aldose Reductase for the Treatment of Diabetes Complications and Inflammatory Diseases: New Insights and Future Directions

(2014) Rosanna Maccari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Thiazolidine-2,4-Dione/Biphenylcarbonitrile Hybrid as Dual PPAR α/γ Modulator with Antidiabetic Effect:In vitro, In SilicoandIn VivoApproaches

(2013) Sergio Hidalgo-Figueroa et al.   Chemical Biology & Drug Design

The importance of synthetic drugs for type 2 diabetes drug discovery

(2013) Maliheh Safavi et al.   Expert Opinion on Drug Discovery

admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties

(2012) Feixiong Cheng et al.   Journal of Chemical Information and Modeling

Effects of antidiabetic drugs in high-fat diet and streptozotocin–nicotinamide-induced type 2 diabetic mice

(2011) Atsuo Tahara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY