Long non-coding RNA-based glycolysis-targeted cancer therapy: feasibility, progression and limitations

Promising RNA-based cancer gene therapy using extracellular vesicles for drug delivery

(2020) Vivian Weiwen Xue et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

HIF1A activates the transcription of lncRNA RAET1K to modulate hypoxia-induced glycolysis in hepatocellular carcinoma cells via miR-100-5p

(2020) Yufan Zhou et al.   Cell Death & Disease

Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming

(2020) Jia Liu et al.   Nature Communications

Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy

(2020) Francesco Mainini et al.   MOLECULES

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

(2020) Chunqing Wang et al.   Nature Communications

LncRNA-DANCR Interferes With miR-125b-5p/HK2 Axis to Desensitize Colon Cancer Cells to Cisplatin vis Activating Anaerobic Glycolysis

(2020) Huijuan Shi et al.   Frontiers in Oncology

ANXA2P2/miR-9/LDHA axis regulates Warburg effect and affects glioblastoma proliferation and apoptosis

(2020) Peng Du et al.   CELLULAR SIGNALLING

Regulation of glycolysis by non-coding RNAs in cancer: Switching on the Warburg effect

(2020) Hamed Mirzaei et al.   Molecular Therapy-Oncolytics

Gynecologic cancers and non-coding RNAs: Epigenetic regulators with emerging roles

(2020) Zahra Sadat Razavi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2

(2019) Meijian Liao et al.   EBioMedicine

Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer

(2019) Jianan Chen et al.   Molecular Cancer

lncRNA PCAT19 promotes the proliferation of laryngocarcinoma cells via modulation of the miR-182/PDK4 axis

(2019) Shuai Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Long non-coding RNA FGF13-AS1 inhibits glycolysis and stemness properties of breast cancer cells through FGF13-AS1/IGF2BPs/Myc feedback loop

(2019) Fei Ma et al.   CANCER LETTERS

Long noncoding RNA MALAT1 mediates stem cell‐like properties in human colorectal cancer cells by regulating miR‐20b‐5p/Oct4 axis

(2019) Dongxin Tang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

(2019) Fei Chen et al.   NATURE CELL BIOLOGY

Metabolism and Disposition of Volanesorsen, a 2′ MOE Antisense Oligonucleotide, Across Species

(2019) Noah Post et al.   DRUG METABOLISM AND DISPOSITION

Monocarboxylate transporters in cancer

(2019) Valéry L. Payen et al.   Molecular Metabolism

LINC00184 silencing inhibits glycolysis and restores mitochondrial oxidative phosphorylation in esophageal cancer through demethylation of PTEN

(2019) Weihao Li et al.   EBioMedicine

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

(2019) Jiyeon Kim et al.   Cell Metabolism

Long Non-Coding RNAs: Epigenetic Regulators in Cancer

(2019) Asma Vafadar et al.   CURRENT PHARMACEUTICAL DESIGN

LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis

(2019) Qian Hua et al.   Journal of Hematology & Oncology

Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis

(2019) Benjamin L. Woolbright et al.   MOLECULAR CANCER THERAPEUTICS

LncRNA ELF3-AS1 is involved in the regulation of oral squamous cell carcinoma cell proliferation by reprogramming glucose metabolism

(2019) Hongxing Chu et al.   OncoTargets and Therapy

L ncRNA‐XIST/microRNA‐126 sponge mediates cell proliferation and glucose metabolism through the IRS1/PI3K/Akt pathway in glioma

(2019) Zhihua Cheng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Long non-coding RNA LINC00504 regulates the Warburg effect in ovarian cancer through inhibition of miR-1244

(2019) Ya Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc

(2019) Jiayin Tang et al.   Nature Communications

3-Bromopyruvate inhibits the malignant phenotype of malignantly transformed macrophages and dendritic cells induced by glioma stem cells in the glioma microenvironment via miR-449a/MCT1

(2019) Yujing Sheng et al.   BIOMEDICINE & PHARMACOTHERAPY

LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

(2019) Yun Wang et al.   Molecular Cancer

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

(2019) Ali F. Abdel-Wahab et al.   PHARMACOLOGICAL RESEARCH

Expression of long non-coding RNA YIYA promotes glycolysis in breast cancer

(2018) Zhen Xing et al.   CANCER RESEARCH

LncRNA-FEZF1-AS1 promotes tumor proliferation and metastasis in colorectal cancer by regulating PKM2 signaling

(2018) Zehua Bian et al.   CLINICAL CANCER RESEARCH

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

(2018) Philippe Icard et al.   DRUG RESISTANCE UPDATES

Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity

(2018) Nicola Amodio et al.   LEUKEMIA

The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1

(2018) Yang Zhao et al.   Molecular Cancer

LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect

(2018) Shaoxun Xiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The impact of tumor cell metabolism on T cell-mediated immune responses and immuno-metabolic biomarkers in cancer

(2018) Grégory Noël et al.   SEMINARS IN CANCER BIOLOGY

Emerging roles of long non-coding RNAs in tumor metabolism

(2018) Hui Sun et al.   Journal of Hematology & Oncology

LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1

(2018) Lin-Yu Sun et al.   Molecular Cancer

Altered cancer metabolism in mechanisms of immunotherapy resistance

(2018) Rishab Ramapriyan et al.   PHARMACOLOGY & THERAPEUTICS

RNA Interference-Based Cancer Drugs: The Roadblocks, and the “Delivery” of the Promise

(2018) Manisit Das et al.   Nucleic Acid Therapeutics

A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth

(2017) Jin-Zhou Huang et al.   MOLECULAR CELL

Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation

(2017) Ruibing Chen et al.   NUCLEIC ACIDS RESEARCH

Promotion of glycolysis by HOTAIR through GLUT1 upregulation via mTOR signaling

(2017) Shibo Wei et al.   ONCOLOGY REPORTS

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

(2017) Peiwen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

(2017) Zhen-Dong Xiao et al.   Nature Communications

The prognostic value of GLUT1 in cancers: a systematic review and meta-analysis

(2017) Min Yu et al.   Oncotarget

IDH mutations in cancer and progress toward development of targeted therapeutics

(2016) L. Dang et al.   ANNALS OF ONCOLOGY

lncRNANBR2modulates cancer cell sensitivity to phenformin through GLUT1

(2016) Xiaowen Liu et al.   CELL CYCLE

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

(2016) Aifu Lin et al.   NATURE CELL BIOLOGY

LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress

(2016) Xiaowen Liu et al.   NATURE CELL BIOLOGY

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches

(2016) Julia Beermann et al.   PHYSIOLOGICAL REVIEWS

PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells

(2016) Suratchanee Phadngam et al.   Oncotarget

Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

(2015) D. G. Hardie   CLINICAL CANCER RESEARCH

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells

(2015) Wei Du et al.   STEM CELLS

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients

(2015) Talia Golan et al.   Oncotarget

Hexokinase 2 as oncotarget.

(2015) Krushna C. Patra et al.   Oncotarget

Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells

(2015) Takumi Shiraishi et al.   Oncotarget

Extracellular acidity, a “reappreciated” trait of tumor environment driving malignancy: perspectives in diagnosis and therapy

(2014) Silvia Peppicelli et al.   CANCER AND METASTASIS REVIEWS

Targeting the Metabolic Plasticity of Multiple Myeloma with FDA-Approved Ritonavir and Metformin

(2014) S. Dalva-Aydemir et al.   CLINICAL CANCER RESEARCH

Phosphofructokinase: A mediator of glycolytic flux in cancer progression

(2014) Nada Al Hasawi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Differential effects of AMPK agonists on cell growth and metabolism

(2014) E E Vincent et al.   ONCOGENE

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27

(2014) A Yalcin et al.   Cell Death & Disease

Reciprocal Regulation of HIF-1α and LincRNA-p21 Modulates the Warburg Effect

(2013) Fan Yang et al.   MOLECULAR CELL

Expression of glucose transporters in cancers

(2012) Leszek Szablewski   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Modular regulatory principles of large non-coding RNAs

(2012) Mitchell Guttman et al.   NATURE

Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins

(2012) Mo Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

(2010) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY