Electron Transfer Dissociation Parameter Optimization Using Design of Experiments Increases Sequence Coverage of Monoclonal Antibodies

Comprehensive Middle-Down Mass Spectrometry Characterization of an Antibody–Drug Conjugate by Combined Ion Activation Methods

(2020) Eleanor Watts et al.   ANALYTICAL CHEMISTRY

Inter-laboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry

(2020) Kristina Srzentic et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Top-down Mass Spectrometry Analysis of Human Serum Autoantibody Antigen-Binding Fragments

(2019) Zhe Wang et al.   Scientific Reports

Classification of Plasma Cell Disorders by 21 Tesla Fourier Transform Ion Cyclotron Resonance Top-Down and Middle-Down MS/MS Analysis of Monoclonal Immunoglobulin Light Chains in Human Serum

(2019) Lidong He et al.   ANALYTICAL CHEMISTRY

Impact of mammalian cell culture conditions on monoclonal antibody charge heterogeneity: an accessory monitoring tool for process development

(2019) Bernhard Sissolak et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

(2019) Daniel P. Donnelly et al.   NATURE METHODS

A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry

(2019) Oscar Hernandez-Alba et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Enhanced Sequence Coverage of Large Proteins by Combining Ultraviolet Photodissociation with Proton Transfer Reactions

(2019) James D. Sanders et al.   ANALYTICAL CHEMISTRY

Antibodies to watch in 2020

(2019) Hélène Kaplon et al.   mAbs

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques

(2018) Luca Fornelli et al.   ANALYTICAL CHEMISTRY

Biopharmaceutical benchmarks 2018

(2018) Gary Walsh   NATURE BIOTECHNOLOGY

Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS

(2017) Lidong He et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Front-End Electron Transfer Dissociation Coupled to a 21 Tesla FT-ICR Mass Spectrometer for Intact Protein Sequence Analysis

(2017) Chad R. Weisbrod et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Characterization of Therapeutic Monoclonal Antibodies at the Subunit-Level using Middle-Down 193 nm Ultraviolet Photodissociation

(2016) Victoria C. Cotham et al.   ANALYTICAL CHEMISTRY

Drug Development of Therapeutic Monoclonal Antibodies

(2016) Diane R. Mould et al.   BIODRUGS

Ion Activation Methods for Peptides and Proteins

(2015) Jennifer S. Brodbelt   ANALYTICAL CHEMISTRY

Enhanced Dissociation of Intact Proteins with High Capacity Electron Transfer Dissociation

(2015) Nicholas M. Riley et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry

(2014) Luca Fornelli et al.   ANALYTICAL CHEMISTRY

Principles of electron capture and transfer dissociation mass spectrometry applied to peptide and protein structure analysis

(2013) Konstantin O. Zhurov et al.   CHEMICAL SOCIETY REVIEWS

Factorial Experimental Designs Elucidate Significant Variables Affecting Data Acquisition on a Quadrupole Orbitrap Mass Spectrometer

(2013) Shan M. Randall et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Optimized Fast and Sensitive Acquisition Methods for Shotgun Proteomics on a Quadrupole Orbitrap Mass Spectrometer

(2012) Christian D. Kelstrup et al.   JOURNAL OF PROTEOME RESEARCH

Two decades of studying non-covalent biomolecular assemblies by means of electrospray ionization mass spectrometry

(2012) G. R. Hilton et al.   Journal of the Royal Society Interface

Analysis of Intact Monoclonal Antibody IgG1 by Electron Transfer Dissociation Orbitrap FTMS

(2012) Luca Fornelli et al.   MOLECULAR & CELLULAR PROTEOMICS

Comparison of the LTQ-Orbitrap Velos and the Q-Exactive for proteomic analysis of 1-1000 ng RAW 264.7 cell lysate digests

(2012) Liangliang Sun et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Structural Analysis of Intact Monoclonal Antibodies by Electron Transfer Dissociation Mass Spectrometry

(2011) Yury O. Tsybin et al.   ANALYTICAL CHEMISTRY

Statistical Analysis of Peptide Electron Transfer Dissociation Fragmentation Mass Spectrometry

(2009) R. J. Chalkley et al.   ANALYTICAL CHEMISTRY

Collisional activation of protein complexes: Picking up the pieces

(2008) Justin L. P. Benesch   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Iodoacetamide-induced artifact mimics ubiquitination in mass spectrometry

(2008) Michael L Nielsen et al.   NATURE METHODS