2’-Hydroxy-4’,5’-dimethyl-4-dimethylaminochalcone, a novel fluorescent flavonoid with capacity to detect aluminium in cells and modulate Alzheimer’s disease targets

Aluminium Drinking Water Treatment Residuals and Their Toxic Impact on Human Health

(2020) Izabela Krupińska   MOLECULES

Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells

(2019) Christian B. Lessard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent and selective inhibition of human monoamine oxidase-B by 4-dimethylaminochalcone and selected chalcone derivatives

(2019) Jong Min Oh et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Aluminium in human brain tissue: how much is too much?

(2019) Christopher Exley et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Aβ, Tau, and α-Synuclein aggregation and integrated role of PARK2 in the regulation and clearance of toxic peptides

(2019) Dhiraj Kumar et al.   NEUROPEPTIDES

Chalconoid metal chelates: spectral, biological and catalytic applications

(2019) Jino Johnson et al.   JOURNAL OF COORDINATION CHEMISTRY

Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects

(2018) Haroon Khan et al.   BIOMEDICINE & PHARMACOTHERAPY

Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection

(2018) Shin-Ying Lee et al.   CNS Neuroscience & Therapeutics

Recent progress in synthesis and characterization of metal chalcone complexes and their potential as bioactive agents

(2018) Chiara Sulpizio et al.   COORDINATION CHEMISTRY REVIEWS

Synthesis and Evaluation of the 4-Substituted 2-Hydroxy-5-Iodochalcones and Their 7-Substituted 6-Iodoflavonol Derivatives for Inhibitory Effect on Cholinesterases and β-Secretase

(2018) Malose Mphahlele et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Copper and Zinc Dysregulation in Alzheimer’s Disease

(2018) Stefano L. Sensi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

(2017) Helena Xicoy et al.   Molecular Neurodegeneration

Clioquinol Decreases Amyloid-β Burden and Reduces Working Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

(2017) Cristina Grossi et al.   JOURNAL OF ALZHEIMERS DISEASE

Challenges Associated with Metal Chelation Therapy in Alzheimer's Disease

(2017) Muralidhar L. Hegde et al.   JOURNAL OF ALZHEIMERS DISEASE

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

(2017) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

(2016) Aedín Cassidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Characterization of the Fluorescence Properties of 4-Dialkylaminochalcones and Investigation of the Cytotoxic Mechanism of Chalcones

(2016) Bo Zhou et al.   ARCHIV DER PHARMAZIE

Alzheimer's disease: Targeting the Cholinergic System

(2016) Talita H. Ferreira-Vieira et al.   Current Neuropharmacology

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Synthesis, Biological Evaluation and Molecular Modelling of 2′-Hydroxychalcones as Acetylcholinesterase Inhibitors

(2016) Sri Sukumaran et al.   MOLECULES

Naturally Inspired Molecules as Multifunctional Agents for Alzheimer’s Disease Treatment

(2016) Angela Rampa et al.   MOLECULES

Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells

(2016) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents

(2015) Damijan Knez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel Potent and Selective Acetylcholinesterase Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease: Synthesis, Pharmacological Evaluation, and Molecular Modeling of Amino-Alkyl-Substituted Fluoro-Chalcones Derivatives

(2015) Hao-Ran Liu et al.   Chemical Biology & Drug Design

Advances in aluminum hydroxide-based adjuvant research and its mechanism

(2015) Peng He et al.   Human Vaccines & Immunotherapeutics

Design, synthesis and biological activity of multifunctional α,β-unsaturated carbonyl scaffolds for Alzheimer’s disease

(2013) Seema Bag et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The development of simple and sensitive small-molecule fluorescent probes for the detection of serum proteins after native polyacrylamide gel electrophoresis

(2012) Fangfang Wang et al.   ANALYST

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Mutations That Replace Aromatic Side Chains Promote Aggregation of the Alzheimer’s Aβ Peptide

(2011) Anne H. Armstrong et al.   BIOCHEMISTRY

Chemical Modification of the Multitarget Neuroprotective Compound Fisetin

(2011) Chandramouli Chiruta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Electronically excited states of membrane fluorescent probe 4-dimethylaminochalcone. Results of quantum chemical calculations

(2011) Alexey N. Romanov et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Synthesis and biological evaluation of indole-chalcone derivatives as β-amyloid imaging probe

(2010) Mengchao Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

Some fluorescence properties of dimethylaminochalcone and its novel cyclic analogues

(2009) Vladimíra Tomečková et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY