Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

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Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease

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Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments

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Analysis of protein-coding genetic variation in 60,706 humans

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An atomic structure of human γ-secretase

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Therapeutic modulation of Notch signalling — are we there yet?

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γ-Secretase Processing and Effects of γ-Secretase Inhibitors and Modulators on Long Aβ Peptides in Cells

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Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

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Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

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Alzheimer's Disease: Presenilin 2-Sparing  -Secretase Inhibition Is a Tolerable A  Peptide-Lowering Strategy

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What the halted phase III γ-secretase inhibitor trial may (or may not) be telling us

(2011) Nina F. Schor   ANNALS OF NEUROLOGY

Identification of Presenilin 1-Selective γ-Secretase Inhibitors with Reconstituted γ-Secretase Complexes

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Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

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NerveCenter: Phase III Alzheimer trial halted: Search for therapeutic biomarkers continues

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What Can Be Inferred from the Interruption of the Semagacestat Trial for Treatment of Alzheimer's Disease?

(2010) Jeffrey Cummings   BIOLOGICAL PSYCHIATRY

And four equals one: Presenilin takes the  -secretase role by itself

(2010) C. B. Lessard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation and intrinsic  -secretase activity of presenilin 1

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