Luteolin inhibits NLRP3 inflammasome activation via blocking ASC oligomerization

Inflammasome Adaptor ASC Is Highly Elevated in Lung Over Plasma and Relates to Inflammation and Lung Diffusion in the Absence of Speck Formation

(2020) Mikhail A. Gavrilin et al.   Frontiers in Immunology

Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss

(2020) Y. Zang et al.   JOURNAL OF DENTAL RESEARCH

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Luteolin attenuates high glucose-induced podocyte injury via suppressing NLRP3 inflammasome pathway

(2019) Qian Yu et al.   LIFE SCIENCES

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

Luteolin reduces adipose tissue macrophage inflammation and insulin resistance in postmenopausal obese mice

(2019) Yunjung Baek et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Pharmacological Inhibitors of the NLRP3 Inflammasome

(2019) Ayesha Zahid et al.   Frontiers in Immunology

Loss of ovarian function in association with a high-fat diet promotes insulin resistance and disturbs adipose tissue immune homeostasis

(2018) Munkyong Pae et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

(2018) Agampodi Promoda Perera et al.   Scientific Reports

Differential Regulation of IL-1β and IL-6 Release in Murine Macrophages

(2017) Seishiro Hirano et al.   INFLAMMATION

Estradiol inhibits NLRP3 inflammasome in fibroblast-like synoviocytes activated by lipopolysaccharide and adenosine triphosphate

(2017) Jianfeng Shi et al.   International Journal of Rheumatic Diseases

Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis

(2017) Talita P. Domiciano et al.   Scientific Reports

Anti-arthritic activity of luteolin in Freund’s complete adjuvant-induced arthritis in rats by suppressing P2X4 pathway

(2015) Fengchao Shi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation

(2015) Wenjie Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

ATP-Binding Pocket-Targeted Suppression of Src and Syk by Luteolin Contributes to Its Anti-Inflammatory Action

(2015) Jeong-Oog Lee et al.   MEDIATORS OF INFLAMMATION

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1  in Mouse Macrophage

(2014) P. Pelegrin et al.   JOURNAL OF IMMUNOLOGY

Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats

(2013) Aroa Jiménez-Aranda et al.   JOURNAL OF PINEAL RESEARCH

The ATP-P2X7 Signaling Axis Is Dispensable for Obesity-Associated Inflammasome Activation in Adipose Tissue

(2012) S. Sun et al.   DIABETES

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

(2012) M. Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY