Sirukumab: A Potential Treatment for Mood Disorders?

The Prevalence, Measurement, and Treatment of the Cognitive Dimension/Domain in Major Depressive Disorder

(2015) Roger S. McIntyre et al.   CNS DRUGS

The impact of cognitive impairment on perceived workforce performance: Results from the International Mood Disorders Collaborative Project

(2015) Roger S. McIntyre et al.   COMPREHENSIVE PSYCHIATRY

Novel investigational drugs targeting IL-6 signaling for the treatment of depression

(2015) Trehani M Fonseka et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Inflammation as a neurobiological substrate of cognitive impairment in bipolar disorder: Evidence, pathophysiology and treatment implications

(2015) Joshua D. Rosenblat et al.   JOURNAL OF AFFECTIVE DISORDERS

A Vision for Drug Discovery and Development: Novel Targets and Multilateral Partnerships

(2014) Roger S. McIntyre   ADVANCES IN THERAPY

An Inflammatory Biomarker as a Differential Predictor of Outcome of Depression Treatment With Escitalopram and Nortriptyline

(2014) Rudolf Uher et al.   AMERICAN JOURNAL OF PSYCHIATRY

Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy

(2014) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting classical IL-6 signalling or IL-6trans-signalling in depression?

(2014) Michael Maes et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Proteomic changes in serum of first onset, antidepressant drug-naïve major depression patients

(2014) Viktoria Stelzhammer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Inflammation, Obesity, and Metabolic Syndrome in Depression

(2014) Chad D. Rethorst et al.   JOURNAL OF CLINICAL PSYCHIATRY

Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress

(2014) Georgia E. Hodes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

(2014) George M. Slavich et al.   PSYCHOLOGICAL BULLETIN

Adverse effects from antidepressant treatment: randomised controlled trial of 601 depressed individuals

(2014) Andrew A. Crawford et al.   PSYCHOPHARMACOLOGY

Efficacy of Pharmacotherapy and Psychotherapy for Adult Psychiatric Disorders

(2014) Maximilian Huhn et al.   JAMA Psychiatry

Malaise, melancholia and madness: The evolutionary legacy of an inflammatory bias

(2013) Charles L. Raison et al.   BRAIN BEHAVIOR AND IMMUNITY

Pharmacokinetics and safety of sirukumab following a single subcutaneous administration to healthy Japanese and Caucasian subjects

(2013) Yanli Zhuang et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

CRP, IL-6 and depression: A systematic review and meta-analysis of longitudinal studies

(2013) Vyara Valkanova et al.   JOURNAL OF AFFECTIVE DISORDERS

Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder

(2013) Daimei Sasayama et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Neural correlates of mindfulness meditation-related anxiety relief

(2013) Fadel Zeidan et al.   Social Cognitive and Affective Neuroscience

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes

(2012) S J Sukoff Rizzo et al.   Translational Psychiatry

Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-in-human study

(2011) Zhenhua Xu et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cytokine levels in the blood may distinguish suicide attempters from depressed patients

(2010) Shorena Janelidze et al.   BRAIN BEHAVIOR AND IMMUNITY

Prevalence and predictors of recurrence of major depressive disorder in the adult population

(2009) F. Hardeveld et al.   ACTA PSYCHIATRICA SCANDINAVICA

Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity

(2009) Daniel Lindqvist et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Depression, traumatic stress and interleukin-6

(2009) Petr Bob et al.   JOURNAL OF AFFECTIVE DISORDERS

The genetics of bipolar disorder

(2009) J.H. Barnett et al.   NEUROSCIENCE

Activation of Central Nervous System Inflammatory Pathways by Interferon-Alpha: Relationship to Monoamines and Depression

(2008) Charles L. Raison et al.   BIOLOGICAL PSYCHIATRY

Functional polymorphisms in the interleukin-6 and serotonin transporter genes and depression and fatigue induced by interferon-α and ribavirin treatment

(2008) S J Bull et al.   MOLECULAR PSYCHIATRY

The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer

(2008) Willscott E. Naugler et al.   TRENDS IN MOLECULAR MEDICINE

Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder

(2007) Triin Eller et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY