Article
Biochemistry & Molecular Biology
Gauri Pathak, Shilpi Singh, Priyanka Kumari, Waseem Raza, Yusuf Hussain, Abha Meena
Summary: Cirsimaritin, a dimethoxy flavone found in various plants, exhibits potent anticancer activity in multiple cancer cell lines, particularly showing selective inhibition against NCIH-520 cell-line. It induces apoptosis and increases ROS levels in cells, while also inhibiting the activity of key enzymes related to cancer progression.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Analytical
Yuze Li, Lixia Jiang, Zhenpeng Wang, Yiran Wang, Xiaohua Cao, Lingwei Meng, Jinghan Fan, Caiqiao Xiong, Zongxiu Nie
Summary: A noninvasive profiling method for bladder cancer diagnosis based on carbonyl metabolic fingerprints using a DSI-MS platform with DMED as a labeling reagent has been developed. This method achieves a high accuracy in distinguishing bladder cancer patients from controls. It may pave the way for patient-friendly point-of-care diagnosis of bladder cancer.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Heidi Kaprio, Arafat Siddiqui, Lotta Saustila, Vanina D. Heuser, Maria Gardberg
Summary: The EWSR1::CREM fusion gene, caused by a chromosomal translocation t(10;22)(p11;q12), has been found in various types of cancers with different malignancy levels. The fusion gene leads to production of a chimeric protein, EWSR1::CREM. However, the molecular mechanisms of EWSR1::CREM protein's oncogenic properties have not been systematically characterized. This study used siRNA mediated knockdown to investigate the effects of depletion of EWSR1::CREM protein on gene expression in a melanoma cell line, identified altered pathways and demonstrated the functional differences. The findings contribute to understanding the pathogenesis of tumors with EWSR1::CREM fusion gene and may aid in the development of novel therapeutic strategies.
SCIENTIFIC REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Chunyang Niu, Sujuan Zhang, Guilin Mo, Yilong Jiang, Liang Li, Hengyong Xu, Chunchun Han, Hua Zhao, Yanhong Yan, Shenqiang Hu, Jiwei Hu, Bo Kang, Dongmei Jiang
Summary: In this study, we successfully induced ODC interference and overexpression in goose ovarian GCs, mainly affecting putrescine content with slight influence on spermidine and spermine. Additionally, ODC participated in regulating P4 levels in the culture medium of GCs, promoting granulosa cell proliferation, and inhibiting granulosa cell apoptosis.
Article
Cell Biology
Yi-Liang Liu, I-Hsin Hsiao, Yen-Hung Lin, Chih-Li Lin, Ming-Shiou Jan, Hui-Chih Hung, Guang-Yaw Liu
Summary: We present a mechanism for how ornithine decarboxylase (ODC) regulates the crosstalk between autophagy and apoptosis. ODC inhibits UVBL-induced autophagy but induces UVBH-induced autophagy and inhibits UVBH-induced apoptosis. Silencing BECN1, Atg5, and Atg12 genes affects autophagy and apoptosis levels, and ODC-induced autophagy protects against UVBH-induced apoptosis via the Atg12 protein.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Editorial Material
Dermatology
Kira Allmeroth, Martin S. Denzel
Summary: Polyamines play a critical role in keratinocyte differentiation, with AMD1 mediating the shift in polyamine ratios. Targeting polyamine availability may be beneficial in treating hyperproliferative skin disorders.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Chemistry, Analytical
Yue Sun, Zhi Zhou, Bing Xie, Zhonghua Wang, Zeper Abliz
Summary: By establishing an AFADESI-MSI system, the molecular information of zebrafish was fully characterized, providing high-quality visual distribution information for over 1000 functional metabolites and mapping a global metabolic network. This comprehensive and in-depth molecular information facilitates the use of zebrafish models in understanding human diseases and developing zebrafish disease models.
ANALYTICAL CHEMISTRY
(2023)
Article
Microbiology
Cun-Cui Kong, Xin Wei, Guang-Lei Liu, Zhen-Ming Chi, Zhe Chi
Summary: In this study, the strain Aureobasidium melanogenum HN6.2 was genetically engineered to enhance siderophore production, ornithine synthesis, and putrescine production. The overexpression of specific genes successfully increased the yields of ornithine and putrescine, making this strain a promising candidate for industrial applications.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Yang Yang, Yu Chong, Mengyuan Chen, Wumin Dai, Xia Zhou, Yongling Ji, Guoqin Qiu, Xianghui Du
Summary: The study found that LDHA is overexpressed in NSCLC tissues and high LDHA expression is associated with poor prognosis and radioresistance in NSCLC patients. Inhibition of LDHA by oxamate increased radiosensitivity in NSCLC cell lines, induced apoptosis and autophagy, and altered cell cycle distribution. LDHA inhibition also led to ROS accumulation and ATP depletion, which may contribute to increased DNA damage and hinder DNA repair activity. The findings suggest that targeting LDHA may be a potential strategy to enhance radiotherapy efficacy in NSCLC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ningning Liu, Tianpeng Zhang, Clifford J. Steer, Guisheng Song
Summary: miR-378a prevents colorectal cancer by inhibiting polyamine synthesis, suggesting its potential as a therapeutic agent against CRC.
CELL AND BIOSCIENCE
(2022)
Article
Plant Sciences
Pooja Makhija, Harish K. Handral, Gomathi Mahadevan, Himanshu Kathuria, Gautam Sethi, Bert Grobben
Summary: This study demonstrates the apoptosis-inducing potential of Amomum subulatum fruit extracts on lung cancer cells and confirms DNA damage as one of the causes of cell death. Further research is needed to determine the most active constituents in Amomum subulatum.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Schroder, Maria Petrova, Zlatina Vlahova, Georgi M. Dobrikov, Ivaylo Slavchev, Evdokia Pasheva, Iva Ugrinova
Summary: The successful design of antitumour drugs often involves combining different biologically active subunits to affect multiple cellular regulatory pathways, leading to higher efficacy. In this study, two ferrocene derivatives, DK-164 and CC-78, were tested for their cytotoxic potential on lung cancer cell lines. DK-164 showed selective cytotoxicity towards cancer cells, while CC-78 exhibited higher cytotoxicity without selectivity. The different cellular mechanisms induced by these compounds in lung cancer cells provide insights into the specific functions of functional groups in ferrocene compounds and can guide the design of new antitumour drugs.
Article
Pharmacology & Pharmacy
Yajie Guo, Dan Sang, Bin Guo, Dan Wang, Xinyue Xu, Huili Wang, Cuilan Hou, Longfei Mao, Fang Li, Sanqiang Li
Summary: In this study, a series of novel anticancer compounds were designed and synthesized based on cabotegravir analogues. Compound 5i showed the highest activity, demonstrating promising antitumor abilities against H460 cells. Further investigations indicated that compound 5i induced cell apoptosis and triggered reactive oxygen species (ROS) production, potentially leading to cell death.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Hari Priya Sivakumar, Sathish Sundararajan, Venkatesh Rajendran, Sathishkumar Ramalingam
Summary: This study identified the distribution of plant ODC and revealed the highly conserved regulatory motifs among diverse plant species. ODC plays an important role in plant metabolic pathways and is crucial for the development of ultra-low nicotine content tobacco lines.
Article
Reproductive Biology
Christopher L. J. Lavergne, Yong Tao, Yanping Ren, Nahantara Lafleur, X. Johne Liu
Summary: In mammalian species, the ovaries produce ODC and putrescine during ovulation. Aged mice have reduced levels of periovulatory ODC and putrescine. Supplementation of putrescine improves fertility in aged mice. However, increasing putrescine levels may lead to unwanted side effects. Attempts to increase ovarian putrescine levels through L-ornithine supplementation did not yield desired results.
BIOLOGY OF REPRODUCTION
(2022)
Review
Chemistry, Medicinal
Yusuf Hussain, Suaib Luqman, Abha Meena
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Saleha Anwar, Taj Mohammad, Anas Shamsi, Aarfa Queen, Shahnaz Parveen, Suaib Luqman, Gulam Mustafa Hasan, Khalid A. Alamry, Naved Azum, Abdullah M. Asiri, Md Imtaiyaz Hassan
Review
Pharmacology & Pharmacy
Shilpi Singh, Waseem Raza, Shahnaz Parveen, Abha Meena, Suaib Luqman
Summary: miRNAs, as non-coding nucleotide sequences, play a crucial role in cancer development, with evidence suggesting that their deregulation is associated with tumorigenesis. Flavonoids are known to modulate miRNAs expression, potentially serving as chemopreventive agents by targeting miRNAs involved in cancer progression. While extensively studied in pre-clinical settings, more research is needed to explore the clinical implications of flavonoids in targeting miRNAs for cancer prevention and treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Shilpi Singh, Abha Meena, Suaib Luqman
Summary: Baicalin has shown significant anti-proliferative potential in various cancer cell lines, attracting interest as a potential chemotherapeutic modality. However, its clinical use is limited by low bioavailability, fast metabolism, and other factors. Improving pharmacokinetics and pharmacodynamics, as well as addressing knowledge and technology gaps, are essential for establishing baicalin as an effective and safe compound for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Chemistry, Medicinal
Jyoti Singh, Yusuf Hussain, Suaib Luqman, Abha Meena
Summary: Purpurin is a natural anthraquinone compound found in Rubia cordifolia roots, with antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It has the potential to influence cell survival and exert anticancer effects through various mechanisms, including its ability to cross the blood-brain barrier.
PHYTOTHERAPY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Richa Seth, Soni Kushwaha, Suaib Luqman, Abha Meena
Summary: Flavonoids act as potential anticancer agents by targeting aromatase to inhibit the growth of transformed cells. However, they have limitations such as low absorption and potential side effects, which are being addressed through advanced nanotechnological approaches. This review also discusses how flavonoids modulate aromatase signaling pathways and the use of nanoparticles to improve their pharmacokinetics and toxicity in targeting aromatase.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kaneez Fatima, Suaib Luqman
Summary: The study shows that citronellal has antiproliferative effects on TNBC cells, suppressing cell growth significantly in NRU, SRB, and MTT assays. It targets molecular pathways such as LOX-5 and microtubule polymerization. In addition, citronellal demonstrates efficacy in inhibiting tumor growth in an EAC model and is found to be non-toxic in mice at certain dosages.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Kaneez Fatima, Zahoor Ahmad Wani, Abha Meena, Suaib Luqman
Summary: Geraniol, a acyclic monoterpene found in plant essential oils, has shown potent antiproliferative and antitumor effects through its antiinflammatory and antioxidant properties. Molecular and cell-based assays revealed its ability to inhibit cancer cell proliferation, affect gene expression, and interact with molecular targets. In animal models, geraniol demonstrated tumor growth inhibition and displayed safety at certain concentrations, suggesting its potential as a novel anticancer agent.
PHYTOTHERAPY RESEARCH
(2021)
Article
Plant Sciences
Kaneez Fatima, Suaib Luqman
Summary: Citronellal exhibits antiproliferative effects on hypopharyngeal carcinoma cells by suppressing ornithine decarboxylase activity, while being non-toxic to normal cells. It shows potential as a prototype for designing new ODC inhibitors.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Chemistry, Medicinal
Shilpi Singh, Pratik Narain Srivastava, Abha Meena, Suaib Luqman
Summary: This study identified the flavonoid narirutin as a potential antagonist of miRNAs through molecular docking simulation, which disrupts the synthesis and processing of miRNA and shows potential for cancer prevention and treatment.
PHYTOTHERAPY RESEARCH
(2022)
Review
Chemistry, Medicinal
K. M. Uma Kumari, Narayan Prasad Yadav, Suaib Luqman
Summary: This review focuses on the occurrence and etiology of dandruff, as well as the potential application of plant essential oils/extracts and novel treatment strategies. Current findings suggest that topical antifungals are the first line of treatment, but they have specific side effects. Alternative therapies, such as tea tree oil, thyme, and Aloe vera, have shown anti-dandruff activity by disrupting microbial growth.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Food Science & Technology
Shilpi Singh, Akhilesh Kumar Maurya, Abha Meena, Nidhi Mishra, Suaib Luqman
Summary: This study investigated the binding affinity of myricitrin to CATD and found a strong affinity. The stability of the complex was confirmed through molecular dynamics simulation, and enzyme activity studies showed inhibitory concentration. The experimental findings suggest that myricitrin could be a potential therapeutic agent for CATD-mediated lung cancer.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Waseem Raza, Abha Meena, Suaib Luqman
Summary: This study explores the potential of 3,5,7-trihydroxyflavone (THF) in inhibiting prostate cancer cell growth through reactive oxygen species (ROS) generation and also examines its tumor reduction potential in mice.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
Yusuf Hussain, Jyoti Singh, Abha Meena, Rohit Anthony Sinha, Suaib Luqman
Summary: This study explores the therapeutic potential of combining escin with sorafenib and finds that the combination treatment can significantly reduce the effective dose of sorafenib and inhibit autophagy in lung cancer cells, inducing late apoptosis.
PHYTOTHERAPY RESEARCH
(2023)
Review
Chemistry, Medicinal
Anurag Mathur, Abha Meena, Suaib Luqman
Summary: Monoterpenoids, a subclass of terpenoids, have been extensively studied for their antitumor properties, including antiproliferative, apoptotic, antiangiogenic, and antimetastatic effects. This review focuses on the effects of specific monoterpenoids on metastasis and relevant signaling pathways. Monoterpenoids exhibit complexity as natural products that regulate metastatic proteins through various signaling pathways. However, limited clinical trials hinder the drug usage of monoterpenoids in preventing cancer metastasis.
PHYTOTHERAPY RESEARCH
(2023)