Sesquiterpene lactones; Damsin and neoambrosin suppress cytokine-mediated inflammation in complete Freund's adjuvant rat model via shutting Akt/ERK1/2/STAT3 signaling

Polystichum braunii extracts inhibit Complete Freund’s adjuvant-induced arthritis via upregulation of I-κB, IL-4, and IL-10, downregulation of COX-2, PGE2, IL-1β, IL-6, NF-κB, and TNF-α, and subsiding oxidative stress

(2020) Ammara Saleem et al.   INFLAMMOPHARMACOLOGY

Nicorandil abates arthritic perturbations induced by complete Freund's adjuvant in rats via conquering TLR4-MyD88-TRAF6 signaling pathway

(2019) Muhammed A. Saad et al.   LIFE SCIENCES

Sam68 Promotes Invasion, Migration, and Proliferation of Fibroblast-like Synoviocytes by Enhancing the NF-κB/P65 Pathway in Rheumatoid Arthritis

(2018) Weiwei Sun et al.   INFLAMMATION

Sesquiterpene lactones from Ambrosia arborescens Mill. inhibit pro-inflammatory cytokine expression and modulate NF-κB signaling in human skin cells

(2018) Daniel Svensson et al.   PHYTOMEDICINE

Diagnosis and Management of Rheumatoid Arthritis

(2018) Daniel Aletaha et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic deletion of GIT2 prolongs functional recovery and suppresses chondrocyte differentiation in rats with rheumatoid arthritis

(2017) Hui Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Total sesquiterpene lactones prepared from Inula helenium L. has potentials in prevention and therapy of rheumatoid arthritis

(2017) Shuang Gao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inhibition of TNF-α-Induced Inflammation by Sesquiterpene Lactones from Saussurea lappa and Semi-Synthetic Analogues

(2017) Siwattra Choodej et al.   PLANTA MEDICA

Methods Used to Evaluate Pain Behaviors in Rodents

(2017) Jennifer R. Deuis et al.   Frontiers in Molecular Neuroscience

The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation

(2017) Igor A. Schepetkin et al.   PHYTOCHEMISTRY

Enhancement of CCL2 expression and monocyte migration by CCN1 in osteoblasts through inhibiting miR-518a-5p: implication of rheumatoid arthritis therapy

(2017) Cheng-Yu Chen et al.   Scientific Reports

Cyr61 participates in the pathogenesis of rheumatoid arthritis via promoting MMP-3 expression by fibroblast-like synoviocytes

(2016) Tianhang Zhai et al.   Modern Rheumatology

Micheliolide inhibits LPS-induced inflammatory response and protects mice from LPS challenge

(2016) Xiangyang Qin et al.   Scientific Reports

IL-6 blockade reverses the abnormal STAT activation of peripheral blood leukocytes from rheumatoid arthritis patients

(2015) M.A. Ortiz et al.   CLINICAL IMMUNOLOGY

The PI3K/Akt/PTEN/mTOR pathway: a fruitful target for inducing cell death in rheumatoid arthritis?

(2015) Charles J Malemud   Future Medicinal Chemistry

Anti-inflammatory activity of atractylenolide III through inhibition of nuclear factor-κB and mitogen-activated protein kinase pathways in mouse macrophages

(2015) Guang-Quan Ji et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

(2015) Bianca Ivanescu et al.   Journal of Analytical Methods in Chemistry

Cytotoxicity of the Sesquiterpene Lactones Neoambrosin and Damsin from Ambrosia maritima Against Multidrug-Resistant Cancer Cells

(2015) Mohamed Saeed et al.   Frontiers in Pharmacology

Effect of Natural and Semisynthetic Pseudoguianolides on the Stability of NF-κB:DNA Complex Studied by Agarose Gel Electrophoresis

(2015) Rodrigo Villagomez et al.   PLoS One

Interleukin 6 and Rheumatoid Arthritis

(2014) Yuji Yoshida et al.   Biomed Research International

Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A

(2013) G W Jones et al.   ANNALS OF THE RHEUMATIC DISEASES

The Novel Role of IL-7 Ligation to IL-7 Receptor in Myeloid Cells of Rheumatoid Arthritis and Collagen-Induced Arthritis

(2013) Z. Chen et al.   JOURNAL OF IMMUNOLOGY

Cyr61 is involved in neutrophil infiltration in joints by inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis

(2013) Xianjin Zhu et al.   ARTHRITIS RESEARCH & THERAPY

PI3 Kinase δ Is a Key Regulator of Synoviocyte Function in Rheumatoid Arthritis

(2012) Beatrix Bartok et al.   AMERICAN JOURNAL OF PATHOLOGY

Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling

(2012) Sang-Heng Kok et al.   ARTHRITIS AND RHEUMATISM

Cyr61 Induces IL-6 Production by Fibroblast-like Synoviocytes Promoting Th17 Differentiation in Rheumatoid Arthritis

(2012) J. Lin et al.   JOURNAL OF IMMUNOLOGY

Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage

(2010) Samuel García et al.   ARTHRITIS RESEARCH & THERAPY

Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain

(2009) Eléonore Beurel et al.   Journal of Neuroinflammation

Treatment options in patients with rheumatoid arthritis failing initial TNF inhibitor therapy: a critical review

(2009) Andrea Rubbert-Roth et al.   ARTHRITIS RESEARCH & THERAPY

Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer

(2008) Y. Rebecca Chin et al.   CELLULAR SIGNALLING

Signalling, inflammation and arthritis: NF- B and its relevance to arthritis and inflammation

(2008) R. E. Simmonds et al.   RHEUMATOLOGY