Trio family proteins as regulators of cell migration and morphogenesis in development and disease – mechanisms and cellular contexts

Opposite Modulation of RAC1 by Mutations in TRIO Is Associated with Distinct, Domain-Specific Neurodevelopmental Disorders

(2020) Sónia Barbosa et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Kalirin and Trio: RhoGEFs in synaptic transmission, plasticity, and complex brain disorders

(2020) Jeremiah D. Paskus et al.   TRENDS IN NEUROSCIENCES

Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits

(2019) Sara Marie Katrancha et al.   Cell Reports

Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential

(2019) Sumit J. Bandekar et al.   Science Signaling

Mechanisms of Notch signaling: a simple logic deployed in time and space

(2019) Domingos Henrique et al.   DEVELOPMENT

Golgi-resident TRIO regulates membrane trafficking during neurite outgrowth

(2019) Tao Tao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action

(2019) Jeremiah D. Paskus et al.   Cell Reports

Trio GEF mediates RhoA activation downstream of Slit2 and coordinates telencephalic wiring

(2018) Stéphanie Backer et al.   DEVELOPMENT

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability

(2018) Kevin Kruse et al.   JOURNAL OF CELL BIOLOGY

Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity

(2017) Sara M Katrancha et al.   HUMAN MOLECULAR GENETICS

Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio

(2017) Alejandra Valdivia et al.   MOLECULAR BIOLOGY OF THE CELL

Flow-induced endothelial cell alignment requires the RhoGEF Trio as a scaffold protein to polarize active Rac1 distribution

(2017) Jeffrey Kroon et al.   MOLECULAR BIOLOGY OF THE CELL

A non-canonical Notch complex regulates adherens junctions and vascular barrier function

(2017) William J. Polacheck et al.   NATURE

Knockdown of Trio by CRISPR/Cas9 suppresses migration and invasion of cervical cancer cells

(2017) Congzhe Hou et al.   ONCOLOGY REPORTS

An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio

(2017) Anastasiia Sadybekov et al.   Nature Communications

Mutations specific to the Rac-GEF domain ofTRIOcause intellectual disability and microcephaly

(2016) Reuben J Pengelly et al.   JOURNAL OF MEDICAL GENETICS

Kalirin is required for BDNF-TrkB stimulated neurite outgrowth and branching

(2016) Yan Yan et al.   NEUROPHARMACOLOGY

Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP

(2016) Bruce E. Herring et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation

(2015) Kyonghee Son et al.   Cytoskeleton

Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis ofC. elegans

(2015) Elise Walck-Shannon et al.   DEVELOPMENT

An N-terminal Amphipathic Helix Binds Phosphoinositides and Enhances Kalirin Sec14 Domain-mediated Membrane Interactions

(2015) Megan B. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1

(2015) Jonathan DeGeer et al.   JOURNAL OF CELL BIOLOGY

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1

(2015) I. Timmerman et al.   JOURNAL OF CELL SCIENCE

Upregulated TRIO expression correlates with a malignant phenotype in human hepatocellular carcinoma

(2015) Bin Wang et al.   TUMOR BIOLOGY

Kalirin-9 and Kalirin-12 Play Essential Roles in Dendritic Outgrowth and Branching

(2014) Yan Yan et al.   CEREBRAL CORTEX

Dynamic Microtubules Catalyze Formation of Navigator-TRIO Complexes to Regulate Neurite Extension

(2014) Jeffrey van Haren et al.   CURRENT BIOLOGY

Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl

(2014) Xin-Ming Ma et al.   MOLECULAR BIOLOGY OF THE CELL

Promotion of Colorectal Cancer Invasion and Metastasis through Activation of NOTCH–DAB1–ABL–RHOGEF Protein TRIO

(2014) Masahiro Sonoshita et al.   Cancer Discovery

Kalirin Promotes Neointimal Hyperplasia by Activating Rac in Smooth Muscle Cells

(2013) Jiao-Hui Wu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neuronal Rho GEFs in Synaptic Physiology and Behavior

(2013) Megan B. Miller et al.   NEUROSCIENTIST

The SAX-3 Receptor Stimulates Axon Outgrowth and the Signal Sequence and Transmembrane Domain Are Critical for SAX-3 Membrane Localization in the PDE Neuron of C. elegans

(2013) Jia Li et al.   PLoS One

The many faces of the guanine-nucleotide exchange factor trio

(2013) Jos van Rijssel et al.   Cell Adhesion & Migration

The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2

(2013) J. Van Rijssel et al.   Biology Open

Tyrosine Phosphorylation of the Rho Guanine Nucleotide Exchange Factor Trio Regulates Netrin-1/DCC-Mediated Cortical Axon Outgrowth

(2012) J. DeGeer et al.   MOLECULAR AND CELLULAR BIOLOGY

The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation

(2012) Jos van Rijssel et al.   MOLECULAR BIOLOGY OF THE CELL

A Genome-wide RNAi Screen Reveals a Trio-Regulated Rho GTPase Circuitry Transducing Mitogenic Signals Initiated by G Protein-Coupled Receptors

(2012) Jose P. Vaqué et al.   MOLECULAR CELL

The N-Terminal DH-PH Domain of Trio Induces Cell Spreading and Migration by Regulating Lamellipodia Dynamics in a Rac1-Dependent Fashion

(2012) Jos van Rijssel et al.   PLoS One

Cigarette smoking status has a modifying effect on the association between polymorphisms in KALRN and measures of cardiovascular risk in the diabetes heart study

(2011) Megan E. Rudock et al.   Genes & Genomics

UNC-73/Trio RhoGEF-2 Activity ModulatesCaenorhabditis elegansMotility Through Changes in Neurotransmitter Signaling Upstream of the GSA-1/GαsPathway

(2011) Shuang Hu et al.   GENETICS

Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling

(2011) Tomoki Yano et al.   JOURNAL OF CELL BIOLOGY

Identification of Kalirin-7 as a Potential Post-Synaptic Density Signaling Hub

(2011) Drew D. Kiraly et al.   JOURNAL OF PROTEOME RESEARCH

Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling

(2011) S.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Synapse and Dendrite Maintenance and Their Disruption in Psychiatric and Neurodegenerative Disorders

(2010) Yu-Chih Lin et al.   Annual Review of Neuroscience

MADD-2, a Homolog of the Opitz Syndrome Protein MID1, Regulates Guidance to the Midline through UNC-40 in Caenorhabditis elegans

(2010) Mariam Alexander et al.   DEVELOPMENTAL CELL

Kalirin: a novel genetic risk factor for ischemic stroke

(2010) Tiago Krug et al.   HUMAN GENETICS

Trio Is a Key Guanine Nucleotide Exchange Factor Coordinating Regulation of the Migration and Morphogenesis of Granule Cells in the Developing Cerebellum

(2010) Ya-Jing Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India

(2010) Indranil Chattopadhyay et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility

(2010) Itaru Kushima et al.   SCHIZOPHRENIA BULLETIN

Kalirin12 interacts with dynamin

(2009) Xiaonan Xin et al.   BMC NEUROSCIENCE

A Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway

(2009) Nathalie Bouquier et al.   CHEMISTRY & BIOLOGY

C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development

(2009) P. J. Vanderzalm et al.   DEVELOPMENT

InCytes from MBC, December 2009

(2009)   MOLECULAR BIOLOGY OF THE CELL

Genomewide Association Studies of Stroke

(2009) M. Arfan Ikram et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Guanine Nucleotide Exchange Factors Trio, Ect2, and Vav3 Mediate the Invasive Behavior of Glioblastoma

(2008) Bodour Salhia et al.   AMERICAN JOURNAL OF PATHOLOGY

Autonomous functions for the Sec14p/spectrin-repeat region of Kalirin

(2008) Martin R. Schiller et al.   EXPERIMENTAL CELL RESEARCH

Regulation of Kalirin by Cdk5

(2008) X. Xin et al.   JOURNAL OF CELL SCIENCE

Kalirin-7 Is Required for Synaptic Structure and Function

(2008) X.-M. Ma et al.   JOURNAL OF NEUROSCIENCE

Trio Mediates Netrin-1-Induced Rac1 Activation in Axon Outgrowth and Guidance

(2008) A. Briancon-Marjollet et al.   MOLECULAR AND CELLULAR BIOLOGY

VE-Cadherin

(2007) Dietmar Vestweber   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY