Understanding the effect of increased cell specific productivity on galactosylation of monoclonal antibodies produced using Chinese hamster ovary cells

The Increasingly Human and Profitable Monoclonal Antibody Market

(2018) António L. Grilo et al.   TRENDS IN BIOTECHNOLOGY

Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders

(2018) Eun-Kyung Choi et al.   Scientific Reports

Impact of nucleotide sugar metabolism on protein N-glycosylation in Chinese Hamster Ovary (CHO) cell culture

(2018) Harnish Mukesh Naik et al.   Current Opinion in Chemical Engineering

Dynamics of immature mAb glycoform secretion during CHO cell culture: An integrated modelling framework

(2016) Ioscani Jimenez del Val et al.   Biotechnology Journal

N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies

(2016) Sha Sha et al.   TRENDS IN BIOTECHNOLOGY

Dynamics of immature mAb glycoform secretion during CHO cell culture: An integrated modelling framework

(2016) Ioscani Jimenez del Val et al.   Biotechnology Journal

SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation

(2015) Julien H. Park et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

(2015) Yuzhou Fan et al.   BIOTECHNOLOGY AND BIOENGINEERING

A global RNA-seq-driven analysis of CHO host and production cell lines reveals distinct differential expression patterns of genes contributing to recombinant antibody glycosylation

(2015) Jennifer D. Könitzer et al.   Biotechnology Journal

A global RNA-seq-driven analysis of CHO host and production cell lines reveals distinct differential expression patterns of genes contributing to recombinant antibody glycosylation

(2015) Jennifer D. Könitzer et al.   Biotechnology Journal

Effect of sodium butyrate on the assembly, charge variants, and galactosylation of antibody produced in recombinant Chinese hamster ovary cells

(2014) Jong Kwang Hong et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

(2014) Marija Ivarsson et al.   JOURNAL OF BIOTECHNOLOGY

The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody

(2013) Bo Liu et al.   JOURNAL OF BIOTECHNOLOGY

Isotype and glycoform selection for antibody therapeutics

(2012) Roy Jefferis   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

(2011) Michael J. Gramer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform

(2011) Efren Pacis et al.   BIOTECHNOLOGY AND BIOENGINEERING

A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus

(2011) Ioscani Jimenez del Val et al.   BIOTECHNOLOGY PROGRESS

Overexpression of UDP-GlcNAc transporter partially corrects galactosylation defect caused by UDP-Gal transporter mutation

(2011) Dorota Maszczak-Seneczko et al.   FEBS LETTERS

An investigation of intracellular glycosylation activities in CHO cells: Effects of nucleotide sugar precursor feeding

(2010) Niki S.C. Wong et al.   BIOTECHNOLOGY AND BIOENGINEERING

N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG

(2009) Patrick H. C. van Berkel et al.   BIOTECHNOLOGY PROGRESS

Optimal and consistent protein glycosylation in mammalian cell culture

(2009) P. Hossler et al.   GLYCOBIOLOGY

Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment

(2009) Anne Kantardjieff et al.   JOURNAL OF BIOTECHNOLOGY

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY

Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells

(2008) Joon Chong Yee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Sodium butyrate stimulates monoclonal antibody over-expression in CHO cells by improving gene accessibility

(2007) Zhou Jiang et al.   BIOTECHNOLOGY AND BIOENGINEERING