Basic mechanism of the autonomous ClpG disaggregase

Heat and Pressure Resistance in Escherichia coli Relates to Protein Folding and Aggregation

(2020) Hui Li et al.   Frontiers in Microbiology

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase

(2019) Alexandrea N. Rizo et al.   Nature Communications

Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor

(2019) Célia Deville et al.   Cell Reports

The molecular principles governing the activity and functional diversity of AAA+ proteins

(2019) Cristina Puchades et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stairway to translocation: AAA+ motor structures reveal the mechanisms of ATP‐dependent substrate translocation

(2019) Stephanie N. Gates et al.   PROTEIN SCIENCE

ClpG Provides Increased Heat Resistance by Acting as Superior Disaggregase

(2019) Panagiotis Katikaridis et al.   Biomolecules

Characterization of Escherichia coli possessing the locus of heat resistance isolated from human cases of acute gastroenteritis

(2019) Angela Ma et al.   FOOD MICROBIOLOGY

Regulated Proteolysis in Bacteria

(2018) Samar A. Mahmoud et al.   Annual Review of Biochemistry

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Activation of the DnaK-ClpB Complex is Regulated by the Properties of the Bound Substrate

(2018) Jose Angel Fernández-Higuero et al.   Scientific Reports

Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria

(2017) Changhan Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Turn Up the Heat—Food and Clinical Escherichia coli Isolates Feature Two Transferrable Loci of Heat Resistance

(2017) Erik J. Boll et al.   Frontiers in Microbiology

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase

(2017) Célia Deville et al.   Science Advances

Overlapping and Specific Functions of the Hsp104 N Domain Define Its Role in Protein Disaggregation

(2017) Jungsoon Lee et al.   Scientific Reports

Protein homeostasis — more than resisting a hot bath

(2016) Changhan Lee et al.   CURRENT OPINION IN MICROBIOLOGY

Short communication: Heat-resistant Escherichia coli as potential persistent reservoir of extended-spectrum β-lactamases and Shiga toxin-encoding phages in dairy

(2016) Roger Marti et al.   JOURNAL OF DAIRY SCIENCE

Heat resistance in extended-spectrum beta-lactamase-producing Escherichia coli may favor environmental survival in a hospital setting

(2016) Erik J. Boll et al.   RESEARCH IN MICROBIOLOGY

Some Like It Hot: Heat Resistance of Escherichia coli in Food

(2016) Hui Li et al.   Frontiers in Microbiology

A novel protein quality control mechanism contributes to heat shock resistance of worldwide-distributedPseudomonas aeruginosaclone C strains

(2015) Changhan Lee et al.   ENVIRONMENTAL MICROBIOLOGY

Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines

(2015) Adrian O. Olivares et al.   NATURE REVIEWS MICROBIOLOGY

ClpB N-terminal domain plays a regulatory role in protein disaggregation

(2015) Rina Rosenzweig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic determinants of heat resistance in Escherichia coli

(2015) Ryan G. Mercer et al.   Frontiers in Microbiology

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation

(2014) Marta Carroni et al.   eLife

Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor

(2013) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the Mechanism of Protein Disaggregation Through a ClpB-DnaK Interaction

(2013) R. Rosenzweig et al.   SCIENCE

Concurrent emergence of multidrug resistance and heat resistance by CTX-M-15-encoding conjugative plasmids in Klebsiella pneumoniae

(2012) Martin S. Bojer et al.   APMIS

DnaK Chaperone-dependent Disaggregation by Caseinolytic Peptidase B (ClpB) Mutants Reveals Functional Overlap in the N-terminal Domain and Nucleotide-binding Domain-1 Pore Tyrosine

(2012) Shannon M. Doyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of Ionic Interactions between the Nucleotide Binding Domain 1 (NBD1) and Middle (M) Domain in Hsp100 Disaggregase Unleashes Toxic Hyperactivity and Partial Independence from Hsp70

(2012) Natalia Lipińska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

(2012) Juliane Winkler et al.   JOURNAL OF CELL BIOLOGY

Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces

(2012) Fabian Seyffer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A tightly regulated molecular toggle controls AAA+ disaggregase

(2012) Yuki Oguchi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulatory Circuits of the AAA+ Disaggregase Hsp104

(2011) Titus M. Franzmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat Resistance Mediated by a New Plasmid Encoded Clp ATPase, ClpK, as a Possible Novel Mechanism for Nosocomial Persistence of Klebsiella pneumoniae

(2010) Martin Saxtorph Bojer et al.   PLoS One

DnaK-mediated association of ClpB to protein aggregates. A bichaperone network at the aggregate surface

(2009) Sergio P. Acebrón et al.   FEBS LETTERS

Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

(2009) Janine Kirstein et al.   NATURE REVIEWS MICROBIOLOGY

Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments

(2008) Tobias Haslberger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY