Acetate supplementation produces antidepressant-like effect via enhanced histone acetylation

The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) Alleviates Depression-Like Behavior and Normalizes Epigenetic Changes in the Hippocampus During Ethanol Withdrawal

(2019) Wei-Yang Chen et al.   ALCOHOL

Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation

(2019) Wenting Fang et al.   JOURNAL OF AFFECTIVE DISORDERS

Depression and metabolic syndrome in the older population: A review of evidence

(2018) Nikolena Repousi et al.   JOURNAL OF AFFECTIVE DISORDERS

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation

(2018) Lige Leng et al.   NEURON

Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study

(2018) Neven Henigsberg et al.   CROATIAN MEDICAL JOURNAL

Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression

(2017) Stephanie Njau et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

(2017) Xinjian Li et al.   MOLECULAR CELL

Increased hippocampal tail volume predicts depression status and remission to anti-depressant medications in major depression

(2017) J J Maller et al.   MOLECULAR PSYCHIATRY

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

(2016) Audrey R. Tyrka et al.   BIOLOGICAL PSYCHIATRY

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

(2016) Ji-chun Zhang et al.   Current Neuropharmacology

Increased ventricular cerebrospinal fluid lactate in depressed adolescents

(2016) K.A.L. Bradley et al.   EUROPEAN PSYCHIATRY

Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice

(2016) Lan-yan Lin et al.   Molecular Neurodegeneration

Increased pregenual anterior cingulate glucose and lactate concentrations in major depressive disorder

(2016) J Ernst et al.   MOLECULAR PSYCHIATRY

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

(2016) Elsa M. Meylan et al.   NEUROPHARMACOLOGY

A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson’s Disease

(2016) Shane V. Hegarty et al.   NEUROTOXICITY RESEARCH

Oral acetate supplementation attenuates N-methyl D-aspartate receptor hypofunction-induced behavioral phenotypes accompanied by restoration of acetyl-histone homeostasis

(2016) Seema Singh et al.   PSYCHOPHARMACOLOGY

Metabolic Regulation of Histone Post-Translational Modifications

(2015) Jing Fan et al.   ACS Chemical Biology

Molecular Signatures of Major Depression

(2015) Na Cai et al.   CURRENT BIOLOGY

Preventive effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD)-like behavior in male C57/B6 mice

(2015) Zhongli Wang et al.   NEUROSCIENCE LETTERS

A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression

(2015) Yan Li et al.   Frontiers in Neuroscience

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

The Epidemiology of Depression Across Cultures

(2013) Ronald C. Kessler et al.   Annual Review of Public Health

Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma

(2013) Andrew R. Tsen et al.   INTERNATIONAL JOURNAL OF CANCER

Epigenetics and depression: return of the repressed

(2013) Victoria S. Dalton et al.   JOURNAL OF AFFECTIVE DISORDERS

Histone acetylation: molecular mnemonics on the chromatin

(2013) Johannes Gräff et al.   NATURE REVIEWS NEUROSCIENCE

H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression

(2012) Cristiana Cruceanu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Acetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of neuroinflammation

(2012) Mahmoud L Soliman et al.   Journal of Neuroinflammation

Stress, anxiety, and dendritic spines: What are the connections?

(2012) B. Leuner et al.   NEUROSCIENCE

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

(2012) R. S. Duman et al.   SCIENCE

Acetate supplementation attenuates lipopolysaccharide-induced neuroinflammation

(2011) Chris J. Reisenauer et al.   JOURNAL OF NEUROCHEMISTRY

Altered sirtuin deacetylase gene expression in patients with a mood disorder

(2011) Naoko Abe et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression

(2011) Mahmoud L. Soliman et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A safety trial of high dose glyceryl triacetate for Canavan disease

(2011) Reeval Segel et al.   MOLECULAR GENETICS AND METABOLISM

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition

(2011) Herbert E. Covington et al.   NEUROSCIENCE LETTERS

Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease

(2010) Peethambaran Arun et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

(2010) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Glyceryl triacetate for Canavan disease: A low-dose trial in infants and evaluation of a higher dose for toxicity in the tremor rat model

(2009) C. N. Madhavarao et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Acetate transport and utilization in the rat brain

(2009) Dinesh K. Deelchand et al.   JOURNAL OF NEUROCHEMISTRY

Metabolic Acetate Therapy for the Treatment of Traumatic Brain Injury

(2009) Peethambaran Arun et al.   JOURNAL OF NEUROTRAUMA

Altered gene expression of histone deacetylases in mood disorder patients

(2009) Teruyuki Hobara et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis

(2009) D Taliaz et al.   MOLECULAR PSYCHIATRY