Journal
NEUROSCIENCE LETTERS
Volume 605, Issue -, Pages 24-28Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2015.08.017
Keywords
Ginsenoside Rg1; Post-traumatic stress disorder; Corticosterone; Corticotrophin-releasing hormone; Traditional Chinese medicine
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Funding
- National Natural Science Foundation of China [81303246]
- Qing Lan Project from Jiangsu Provincial Framework Teacher Support Scheme
- Projects of priority-discipline for colleges and universities of Jiangsu province
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We investigated the preventive effects of Rg1 on a model of mouse post-traumatic stress disorder (PTSD) induced by electric shock combined with situation reminder and explored the underlying mechanism. In the experiment, before the PTSD animal model was developed, Rg1 (10, 5, and 2.5 mg/kg) was orally administered for one week. After the animal model was established, PTSD-like behavior was observed using elevated plus maze, black and light box, and open field tests. One hour after the behavior test, all mice were sacrificed, and then serum corticosterone (CORT) and hypothalamus corticotrophin-releasing hormone (CRH) assays were performed. Results showed that Rg1 (5 mg/kg) treatments relieved PTSD-like behavior by altering elevated serum corticosterone and hypothalamus CRH levels. By contrast, fluoxetine (3 mg/kg) treatment reversed the behavior changes and had no effect on increased CORT and CRH levels. These findings confirmed the preventive effect of Rg1 in PTSD model. Decreasing CORT and CRH levels may be one of the underlying mechanisms. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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