Drosophila as a Model for Infectious Diseases

Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies

(2020) Jonathan Zirin et al.   GENETICS

Family History of Gastric Cancer and Helicobacter pylori Treatment

(2020) Il Ju Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Covid-19 — Navigating the Uncharted

(2020) Anthony S. Fauci et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurodevelopment of children exposed intra-uterus by Zika virus: A case series

(2020) Pedro Massaroni Peçanha et al.   PLoS One

A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila

(2020) Fillip Port et al.   eLife

Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders

(2020) Diana C. Muñoz-Lasso et al.   Cells

Zika virus non-structural protein NS4A restricts eye growth in Drosophila through regulation of JAK/STAT signaling

(2020) Sneh Harsh et al.   Disease Models & Mechanisms

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Post-Developmental Roles of Notch Signaling in the Nervous System

(2020) Jose L. Salazar et al.   Biomolecules

JNK signaling in Drosophila immunity and homeostasis

(2020) Ghada Tafesh-Edwards et al.   IMMUNOLOGY LETTERS

Phage Therapy in the Postantibiotic Era

(2019) Fernando L. Gordillo Altamirano et al.   CLINICAL MICROBIOLOGY REVIEWS

Pro-apoptotic and pro-proliferation functions of the JNK pathway of Drosophila : roles in cell competition, tumorigenesis and regeneration

(2019) Noelia Pinal et al.   Open Biology

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

(2019) Simon Langer et al.   eLife

Methods for the study of innate immunity in Drosophila melanogaster

(2019) Katia Troha et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The role of Sevenless in Drosophila R7 photoreceptor specification

(2019) Andrew Tomlinson et al.   DEVELOPMENTAL BIOLOGY

The fruit fly at the interface of diagnosis and pathogenic mechanisms of rare and common human diseases

(2019) Hugo J Bellen et al.   HUMAN MOLECULAR GENETICS

Association Between Simian Virus 40 and Human Tumors

(2019) John Charles Rotondo et al.   Frontiers in Oncology

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

(2019) J. Michael Harnish et al.   Jove-Journal of Visualized Experiments

Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly

(2019) Nichole Link et al.   DEVELOPMENTAL CELL

Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis

(2019) Marc Arbyn et al.   Lancet Global Health

A Review of New Findings in Adult T-cell Leukemia–Lymphoma: A Focus on Current and Emerging Treatment Strategies

(2018) Olivier Hermine et al.   ADVANCES IN THERAPY

Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain

(2018) Yuan Liu et al.   Cell Host & Microbe

NF-κB signaling mechanisms in HTLV-1-induced adult T-cell leukemia/lymphoma

(2018) Edward William Harhaj et al.   FEBS Journal

Human gut microbiome: hopes, threats and promises

(2018) Patrice D Cani   GUT

The HTLV-1 oncoprotein Tax is modified by the ubiquitin related modifier 1 (Urm1)

(2018) Rita Hleihel, Behzad Khoshnood, Ingrid Dacklin, Hayssam Omran, Carine Mouawad, Zeina Dassouki, Marwan El-Sabban, Margret Shirinian, Caroline Grabbe, Ali Bazarbachi   Retrovirology

Did Zika Virus Mutate to Cause Severe Outbreaks?

(2018) Shannan L. Rossi et al.   TRENDS IN MICROBIOLOGY

An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

(2018) Hongjie Xia et al.   Nature Communications

Epstein–Barr Virus and Cancer

(2018) Paul J. Farrell   Annual Review of Pathology-Mechanisms of Disease

Genomic and phenotypic delineation of congenital microcephaly

(2018) Ranad Shaheen et al.   GENETICS IN MEDICINE

Pseudomonas aeruginosa glutathione biosynthesis genes play multiple roles in stress protection, bacterial virulence and biofilm formation

(2018) Lampet Wongsaroj et al.   PLoS One

Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis

(2018) Priya S. Shah et al.   CELL

Dicer-2 Regulates Resistance and Maintains Homeostasis against Zika Virus Infection in Drosophila

(2018) Sneh Harsh et al.   JOURNAL OF IMMUNOLOGY

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research

(2017) Michael F. Wangler et al.   GENETICS

B-cell responses to HIV infection

(2017) Susan Moir et al.   IMMUNOLOGICAL REVIEWS

Influenza

(2017) Catharine Paules et al.   LANCET

Fungal infections in HIV/AIDS

(2017) Andrew H Limper et al.   LANCET INFECTIOUS DISEASES

Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer

(2017) Masanori HATAKEYAMA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly

(2017) Ling Yuan et al.   SCIENCE

The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut

(2017) Tiffani Alvey Jones et al.   PLoS Pathogens

Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport

(2017) Annabel Guichard et al.   PLoS Pathogens

Phagocytosis: A Fundamental Process in Immunity

(2017) Carlos Rosales et al.   Biomed Research International

Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence

(2017) M. Fata Moradali et al.   Frontiers in Cellular and Infection Microbiology

Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research

(2017) Michael F. Wangler et al.   GENETICS

Myristoylation: An Important Protein Modification in the Immune Response

(2017) Daniel Ikenna Udenwobele et al.   Frontiers in Immunology

Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer

(2017) Jay Lusk et al.   Cancers

Cytoplasmic Streaming in the Drosophila Oocyte

(2016) Margot E. Quinlan   Annual Review of Cell and Developmental Biology

The Role of CagA in the Gastric Biology of Helicobacter pylori

(2016) Steffen Backert et al.   CANCER RESEARCH

Aeromonas salmonicida: updates on an old acquaintance

(2016) S Menanteau-Ledouble et al.   DISEASES OF AQUATIC ORGANISMS

Salmonella enteritidisEffector AvrA Stabilizes Intestinal Tight Junctions via the JNK Pathway

(2016) Zhijie Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse studies confirm the link between Zika virus infection and microcephaly

(2016) Hemi Malkki   Nature Reviews Neurology

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

Zika Virus Associated with Microcephaly

(2016) Jernej Mlakar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB

(2016) Yosuke Motai et al.   VIRUS GENES

A Drosophila Model of HPV E6-Induced Malignancy Reveals Essential Roles for Magi and the Insulin Receptor

(2016) Mojgan Padash Barmchi et al.   PLoS Pathogens

Anthrax Pathogenesis

(2015) Mahtab Moayeri et al.   Annual Review of Microbiology

Morgan’s Legacy: Fruit Flies and the Functional Annotation of Conserved Genes

(2015) Hugo J. Bellen et al.   CELL

Drosophilablood cells and their role in immune responses

(2015) Isabella Vlisidou et al.   FEBS Journal

Fruit Flies in Biomedical Research

(2015) M. F. Wangler et al.   GENETICS

Drosophilaas anIn VivoModel for Human Neurodegenerative Disease

(2015) Leeanne McGurk et al.   GENETICS

Human papillomavirus vaccine trials and tribulations

(2015) Marc Z. Handler et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

A Transgenic Drosophila melanogaster Model To Study Human T-Lymphotropic Virus Oncoprotein Tax-1-Driven TransformationIn Vivo

(2015) Margret Shirinian et al.   JOURNAL OF VIROLOGY

Vpu Protein: The Viroporin Encoded by HIV-1

(2015) María González   Viruses-Basel

Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis

(2015) Lisa Nagase et al.   Scientific Reports

The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia

(2015) Stephanie M. Rangel et al.   PLoS Pathogens

Drosophilaas anIn VivoModel for Human Neurodegenerative Disease

(2015) Leeanne McGurk et al.   GENETICS

Genome engineering: Drosophila melanogaster and beyond

(2015) Koen J. T. Venken et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Translational Control in Synaptic Plasticity and Cognitive Dysfunction

(2014) Shelly A. Buffington et al.   Annual Review of Neuroscience

The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1–PKB/Akt signalling

(2014) Ho Tsoi et al.   BIOCHEMICAL JOURNAL

A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases

(2014) Shinya Yamamoto et al.   CELL

Zika virus infection complicated by Guillain-Barré syndrome – case report, French Polynesia, December 2013

(2014) E Oehler et al.   Eurosurveillance

Methods to study Drosophila immunity

(2014) Claudine Neyen et al.   METHODS

Wing tips: The wing disc as a platform for studying Hedgehog signaling

(2014) Tom A. Hartl et al.   METHODS

The Drosophila TNF ortholog Eiger: Emerging physiological roles and evolution of the TNF system

(2014) Tatsushi Igaki et al.   SEMINARS IN IMMUNOLOGY

HIV neuropathy

(2014) Michelle Kaku et al.   Current Opinion in HIV and AIDS

Human pathogenic bacteria, fungi, and viruses inDrosophila

(2014) Stavria Panayidou et al.   Virulence

Drosophila as a model to study the role of blood cells in inflammation, innate immunity and cancer

(2014) Lihui Wang et al.   Frontiers in Cellular and Infection Microbiology

Global burden of deaths from Epstein-Barr virus attributable malignancies 1990-2010

(2014) Gulfaraz Khan et al.   Infectious Agents and Cancer

Cholera Toxin Disrupts Barrier Function by Inhibiting Exocyst-Mediated Trafficking of Host Proteins to Intestinal Cell Junctions

(2013) Annabel Guichard et al.   Cell Host & Microbe

Sequential inactivation of Rho GTPases and Lim kinase by Pseudomonas aeruginosa toxins ExoS and ExoT leads to endothelial monolayer breakdown

(2013) P. Huber et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Drosophila melanogaster: a first step and a stepping-stone to anti-infectives

(2013) Ilias Tzelepis et al.   CURRENT OPINION IN PHARMACOLOGY

Switching cell fates in the developing Drosophila eye

(2013) Y. E. Mavromatakis et al.   DEVELOPMENT

Insights from natural host–parasite interactions: The Drosophila model

(2013) Erin S. Keebaugh et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Tax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation

(2013) Margret Shirinian et al.   Frontiers in Microbiology

Mutations inVRK1Associated With Complex Motor and Sensory Axonal Neuropathy Plus Microcephaly

(2013) Claudia Gonzaga-Jauregui et al.   JAMA Neurology

Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs)

(2013) Jean Berthelet et al.   Cells

Antibacterial Efficacy of Temperate Phage-Mediated Inhibition of Bacterial Group Motilities

(2012) In-Young Chung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ventilator-associated pneumonia caused by Pseudomonas aeruginosa

(2012) Alan R. Hauser   CRITICAL CARE MEDICINE

dEHBP1controls exocytosis and recycling of Delta during asymmetric divisions

(2012) Nikolaos Giagtzoglou et al.   JOURNAL OF CELL BIOLOGY

Human T Cell Leukemia Virus Type 2 Tax-Mediated NF- B Activation Involves a Mechanism Independent of Tax Conjugation to Ubiquitin and SUMO

(2012) C. Journo et al.   JOURNAL OF VIROLOGY

The HIV-1 Vpu Protein Induces Apoptosis in Drosophila via Activation of JNK Signaling

(2012) Christelle Marchal et al.   PLoS One

Nucleolar Protein Trafficking in Response to HIV-1 Tat: Rewiring the Nucleolus

(2012) Mohamed Ali Jarboui et al.   PLoS One

Review of Two Decades of Cholera Diagnostics – How Far Have We Really Come?

(2012) Michal H. Dick et al.   PLoS Neglected Tropical Diseases

Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila

(2012) Anica M. Wandler et al.   PLoS Pathogens

Identification of genetic modifiers of CagA-induced epithelial disruption in Drosophila

(2012) David W. Reid et al.   Frontiers in Cellular and Infection Microbiology

The Epstein-Barr virus replication and transcription activator, Rta/BRLF1, induces cellular senescence in epithelial cells

(2011) Yu-Lian Chen et al.   CELL CYCLE

Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog

(2011) Michael Rera et al.   Cell Metabolism

NF-κB in immunobiology

(2011) Matthew S Hayden et al.   CELL RESEARCH

The Salmonella effector AvrA mediates bacterial intracellular survival during infection in vivo

(2011) Huixia Wu et al.   CELLULAR MICROBIOLOGY

Aeromonas salmonicida-secreted protein AopP is a potent inducer of apoptosis in a mammalian and a Drosophila model

(2011) Rheinallt M. Jones et al.   CELLULAR MICROBIOLOGY

ADrosophilaModel for Genetic Analysis of Influenza Viral/Host Interactions

(2011) Amy L. Adamson et al.   GENETICS

The HIV-1 Tat Protein Has a Versatile Role in Activating Viral Transcription

(2011) A. T. Das et al.   JOURNAL OF VIROLOGY

Helicobacter pylori CagA Disrupts Epithelial Patterning by Activating Myosin Light Chain

(2011) Jonathan B. Muyskens et al.   PLoS One

Drosophila as a genetic model for studying pathogenic human viruses

(2011) Tamara T. Hughes et al.   VIROLOGY

Innate antiviral immunity in Drosophila

(2010) Leah R Sabin et al.   CURRENT OPINION IN IMMUNOLOGY

Drosophila Genetic Resource and Stock Center; The National BioResource Project

(2010) Masa-Toshi YAMAMOTO   EXPERIMENTAL ANIMALS

Regulation of Drosophila lifespan by JNK signaling

(2010) Benoit Biteau et al.   EXPERIMENTAL GERONTOLOGY

New research resources at the Bloomington Drosophila Stock Center

(2010) Kevin R. Cook et al.   FLY

Notch Signaling in the Immune System

(2010) Freddy Radtke et al.   IMMUNITY

A Systematic Analysis of Human Papillomavirus (HPV) E6 PDZ Substrates Identifies MAGI-1 as a Major Target of HPV Type 16 (HPV-16) and HPV-18 Whose Loss Accompanies Disruption of Tight Junctions

(2010) C. Kranjec et al.   JOURNAL OF VIROLOGY

Interaction between Ras V12 and scribbled clones induces tumour growth and invasion

(2010) Ming Wu et al.   NATURE

Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst

(2010) Annabel Guichard et al.   NATURE

Heterodimers of NF- B transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila

(2010) T. Tanji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinal Muscular Atrophy with Pontocerebellar Hypoplasia Is Caused by a Mutation in the VRK1 Gene

(2009) Paul Renbaum et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Antibacterial Efficacy of Phages against Pseudomonas aeruginosa Infections in Mice and Drosophila melanogaster

(2009) Y.-J. Heo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Immunobiology of Human Cytomegalovirus: from Bench to Bedside

(2009) T. Crough et al.   CLINICAL MICROBIOLOGY REVIEWS

The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function

(2009) Chak-Ming Chan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Coordinated Activation of the Origin Licensing Factor CDC6 and CDK2 in Resting Human Fibroblasts Expressing SV40 Small T Antigen and Cyclin E

(2009) Elena Sotillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of Tat: the versatile protein of human immunodeficiency virus type 1

(2009) B. Romani et al.   JOURNAL OF GENERAL VIROLOGY

Architecture and secondary structure of an entire HIV-1 RNA genome

(2009) Joseph M. Watts et al.   NATURE

Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis

(2009) Masaya Higuchi et al.   Retrovirology

NF- B in the Immune Response of Drosophila

(2009) C. Hetru et al.   Cold Spring Harbor Perspectives in Biology

The HIV Tat protein affects processing of ribosomal RNA precursor

(2008) Donatella Ponti et al.   BMC CELL BIOLOGY

Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development

(2008) Tina Jaskoll et al.   BMC DEVELOPMENTAL BIOLOGY

Regulation of apoptosis in Drosophila

(2008) H Steller   CELL DEATH AND DIFFERENTIATION

Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade

(2008) Rheinallt M. Jones et al.   Cell Host & Microbe

Urm1 at the crossroad of modifications. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Patrick G A Pedrioli et al.   EMBO REPORTS

Cyclin E and SV40 Small t Antigen Cooperate to Bypass Quiescence and Contribute to Transformation by Activating CDK2 in Human Fibroblasts

(2008) Elena Sotillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen

(2008) S Kotadia et al.   ONCOGENE

Drosophila follicle cells: Morphogenesis in an eggshell

(2008) Xiaodong Wu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Transgenic Drosophila Model Demonstrates That the Helicobacter pylori CagA Protein Functions as a Eukaryotic Gab Adaptor

(2008) Crystal M. Botham et al.   PLoS Pathogens

Cellular Proteins in Influenza Virus Particles

(2008) Megan L. Shaw et al.   PLoS Pathogens