Design and Evaluation of a Polypeptide that Mimics the Integrin Binding Site for EDA Fibronectin to Block Profibrotic Cell Activity

Mechanical regulation of myofibroblast phenoconversion and collagen contraction

(2019) Boris Hinz et al.   EXPERIMENTAL CELL RESEARCH

The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix

(2018) Franco Klingberg et al.   JOURNAL OF CELL SCIENCE

Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts

(2018) Diana Avery et al.   MATRIX BIOLOGY

Toll-like receptor 4 contributes to a myofibroblast phenotype in cardiac fibroblasts and is associated with autophagy after myocardial infarction in a mouse model

(2018) Ruhui Yang et al.   ATHEROSCLEROSIS

Targeted delivery of calreticulin to ED-A fibronectin leads to tumor-growth retardation

(2018) Barbara Ziffels et al.   JOURNAL OF BIOTECHNOLOGY

Hepatocyte Growth Factor Mediates Enhanced Wound Healing Responses and Resistance to Transforming Growth Factor-β1-Driven Myofibroblast Differentiation in Oral Mucosal Fibroblasts

(2017) Jordanna Dally et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fibronectins containing extradomain A or B enhance osteoblast differentiation via distinct integrins

(2017) Carla Sens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin α4β1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin’s EDA Domain

(2017) Rhiannon M. Kelsh-Lasher et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nuclear hyaluronidase 2 drives alternative splicing ofCD44pre-mRNA to determine profibrotic or antifibrotic cell phenotype

(2017) Adam C. Midgley et al.   Science Signaling

Nuclear hyaluronidase 2 drives alternative splicing ofCD44pre-mRNA to determine profibrotic or antifibrotic cell phenotype

(2017) Adam C. Midgley et al.   Science Signaling

An O-Glycosylation of Fibronectin Mediates Hepatic Osteodystrophy Through α4β1 Integrin

(2016) Carla Sens et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Epithelial-to-mesenchymal transition of tubular epithelial cells in renal fibrosis: a new twist on an old tale

(2016) Madhav C. Menon et al.   KIDNEY INTERNATIONAL

PEP-FOLD3: fasterde novostructure prediction for linear peptides in solution and in complex

(2016) Alexis Lamiable et al.   NUCLEIC ACIDS RESEARCH

Focal Adhesion Kinase Regulates Fibroblast Migration via Integrin beta-1 and Plays a Central Role in Fibrosis

(2016) Xue-Ke Zhao et al.   Scientific Reports

EDA-Fibronectin Originating from Osteoblasts Inhibits the Immune Response against Cancer

(2016) Stephanie Rossnagl et al.   PLOS BIOLOGY

Integrin α3β1 Binding to Fibronectin Is Dependent on the Ninth Type III Repeat

(2015) Ashley C. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan Regulates Bone Morphogenetic Protein-7-dependent Prevention and Reversal of Myofibroblast Phenotype

(2015) Adam C. Midgley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis

(2015) Ayumi Iwasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EDA Fibronectin in Keloids Create a Vicious Cycle of Fibrotic Tumor Formation

(2015) Rhiannon M. Kelsh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Has the search for a marker of activated fibroblasts finally come to an end?

(2015) W. Matthijs Blankesteijn   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The α4β1 integrin and the EDA domain of fibronectin regulate a profibrotic phenotype in dermal fibroblasts

(2015) Arti V. Shinde et al.   MATRIX BIOLOGY

The TLR4 Agonist Fibronectin Extra Domain A is Cryptic, Exposed by Elastase-2; use in a fibrin matrix cancer vaccine

(2015) Ziad Julier et al.   Scientific Reports

Utilizing Fibronectin Integrin-Binding Specificity to Control Cellular Responses

(2015) Haylee Bachman et al.   Advances in Wound Care

Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer

(2015) Julia Femel et al.   Oncotarget

Improved PEP-FOLD Approach for Peptide and Miniprotein Structure Prediction

(2014) Yimin Shen et al.   Journal of Chemical Theory and Computation

PEP-SiteFinder: a tool for the blind identification of peptide binding sites on protein surfaces

(2014) Adrien Saladin et al.   NUCLEIC ACIDS RESEARCH

FibronectinEDA Promotes Chronic Cutaneous Fibrosis Through Toll-Like Receptor Signaling

(2014) S. Bhattacharyya et al.   Science Translational Medicine

Transforming Growth Factor-β1 (TGF-β1)-stimulated Fibroblast to Myofibroblast Differentiation Is Mediated by Hyaluronan (HA)-facilitated Epidermal Growth Factor Receptor (EGFR) and CD44 Co-localization in Lipid Rafts

(2013) Adam C. Midgley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detecting Splicing Variants in Idiopathic Pulmonary Fibrosis from Non-Differentially Expressed Genes

(2013) Nan Deng et al.   PLoS One

Fibronectin extra domain A (EDA) sustains CD133+/CD44+ subpopulation of colorectal cancer cells

(2013) Juanjuan Ou et al.   Stem Cell Research

Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors

(2013) Florence Schaffner et al.   Cancers

Modulation of MMPs by Cell Surface Integrin Receptor α5β1

(2012) Sekhar Pal et al.   Anti-Cancer Agents in Medicinal Chemistry

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides

(2012) P. Thevenet et al.   NUCLEIC ACIDS RESEARCH

The Extra Domain A of Fibronectin Increases VEGF-C Expression in Colorectal Carcinoma Involving the PI3K/AKT Signaling Pathway

(2012) Lisha Xiang et al.   PLoS One

Fibronectin Extra Domain-A Promotes Hepatic Stellate Cell Motility but Not Differentiation Into Myofibroblasts

(2011) Abby L. Olsen et al.   GASTROENTEROLOGY

Fibronectin Protects from Excessive Liver Fibrosis by Modulating the Availability of and Responsiveness of Stellate Cells to Active TGF-β

(2011) Nina Kawelke et al.   PLoS One

Colorectal tumor derived fibronectin alternatively spliced EDA domain exserts lymphangiogenic effect on human lymphatic endothelial cells

(2010) Juan-Juan Ou et al.   CANCER BIOLOGY & THERAPY

EDA-containing cellular fibronectin induces fibroblast differentiation through binding to α4β7 integrin receptor and MAPK/Erk 1/2-dependent signaling

(2010) Martin Kohan et al.   FASEB JOURNAL

Fibronectin–integrin mediated signaling in human cervical cancer cells (SiHa)

(2009) Gargi Maity et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculaturein vivo

(2008) Alessandra Villa et al.   INTERNATIONAL JOURNAL OF CANCER

An Essential Role for Fibronectin Extra Type III Domain A in Pulmonary Fibrosis

(2007) Andrés F. Muro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE