Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut

An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint

(2020) Deepshika Ramanan et al.   CELL

The liver–brain–gut neural arc maintains the Treg cell niche in the gut

(2020) Toshiaki Teratani et al.   NATURE

The Human and Mouse Enteric Nervous System at Single-Cell Resolution

(2020) Eugene Drokhlyansky et al.   CELL

c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis

(2019) Christian Neumann et al.   NATURE IMMUNOLOGY

A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult

(2019) Ziad Al Nabhani et al.   IMMUNITY

Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses

(2019) Antonia Wallrapp et al.   IMMUNITY

Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells

(2019) Alvin Pratama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense

(2019) Nicole Y. Lai et al.   CELL

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

(2019) Xinyang Song et al.   NATURE

Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection

(2018) Felipe A. Pinho-Ribeiro et al.   CELL

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

(2018) Sebastiaan De Schepper et al.   CELL

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

(2018) Mo Xu et al.   NATURE

Advances in Enteric Neurobiology: The “Brain” in the Gut in Health and Disease

(2018) Subhash Kulkarni et al.   JOURNAL OF NEUROSCIENCE

The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut

(2017) Bryan B. Yoo et al.   IMMUNITY

Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt+and Follicular Phenotypes

(2017) Joshua D. Wheaton et al.   JOURNAL OF IMMUNOLOGY

Bacterial Signaling to the Nervous System through Toxins and Metabolites

(2017) Nicole J. Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

(2017) Antonia Wallrapp et al.   NATURE

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

(2017) Christoph S. N. Klose et al.   NATURE

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

(2017) Vânia Cardoso et al.   NATURE

The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells

(2017) Jian Ye et al.   Cell Reports

Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc Min/+ mice

(2017) Zhengxiang He et al.   Scientific Reports

Tissue Tregs

(2016) Marisella Panduro et al.   Annual Review of Immunology

Neuro-Immune Interactions at Barrier Surfaces

(2016) Henrique Veiga-Fernandes et al.   CELL

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

(2016) Ilana Gabanyi et al.   CELL

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

(2016) Wilson Kuswanto et al.   IMMUNITY

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence

(2016) Sales Ibiza et al.   NATURE

Cellular Organization of Neuroimmune Interactions in the Gastrointestinal Tract

(2016) Kara Gross Margolis et al.   TRENDS IN IMMUNOLOGY

IL-33 in T Cell Differentiation, Function, and Immune Homeostasis

(2016) Michael Peine et al.   TRENDS IN IMMUNOLOGY

Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery

(2016) Katherine Nutsch et al.   Cell Reports

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

(2015) Ari B. Molofsky et al.   IMMUNITY

Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

(2015) B-H Yang et al.   Mucosal Immunology

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

IL-6 regulation of synaptic function in the CNS

(2015) Donna L. Gruol   NEUROPHARMACOLOGY

Vasoactive Intestinal Polypeptide Promotes Intestinal Barrier Homeostasis and Protection Against Colitis in Mice

(2015) Xiujuan Wu et al.   PLoS One

The microbiota regulates type 2 immunity through ROR t+ T cells

(2015) C. Ohnmacht et al.   SCIENCE

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

(2014) Paul Andrew Muller et al.   CELL

TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP

(2014) P R de Jong et al.   Mucosal Immunology

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

(2014) Victor Meseguer et al.   Nature Communications

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

The gut as a sensory organ

(2013) John B. Furness et al.   Nature Reviews Gastroenterology & Hepatology

Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behavior

(2012) Albert Quintana et al.   BRAIN BEHAVIOR AND IMMUNITY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis

(2011) Matthias A. Engel et al.   DIGESTIVE AND LIVER DISEASE

Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut

(2011) Nancy M. Joseph et al.   JOURNAL OF CLINICAL INVESTIGATION

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

(2011) Elizabeth A. Wohlfert et al.   JOURNAL OF CLINICAL INVESTIGATION

Peripheral education of the immune system by colonic commensal microbiota

(2011) Stephanie K. Lathrop et al.   NATURE

Single-molecule transcript counting of stem-cell markers in the mouse intestine

(2011) Shalev Itzkovitz et al.   NATURE CELL BIOLOGY

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology