Navigating the murky waters of maternal fetal tolerance: Put big data at the helm

CD8+ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization

(2020) Jeremy M. Kinder et al.   Cell Reports

Analysis of TCR Repertoire and PD-1 Expression in Decidual and Peripheral CD8+ T Cells Reveals Distinct Immune Mechanisms in Miscarriage and Preeclampsia

(2020) Keiko Morita et al.   Frontiers in Immunology

Exploring the Origin and Antigenic Specificity of Maternal Regulatory T Cells in Pregnancy

(2020) Soo Hyun Ahn et al.   Frontiers in Immunology

Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy

(2019) Seunghee Hong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface

(2019) Maria Salvany-Celades et al.   Cell Reports

Thymus-Derived Regulatory T Cells Exhibit Foxp3 Epigenetic Modification and Phenotype Attenuation after Mating in Mice

(2019) Lachlan M. Moldenhauer et al.   JOURNAL OF IMMUNOLOGY

Immune Checkpoint Molecules in Reproductive Immunology

(2019) Eva Miko et al.   Frontiers in Immunology

The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface

(2019) Henrieta Papúchová et al.   Frontiers in Immunology

The Cellular Transcriptome in the Maternal Circulation During Normal Pregnancy: A Longitudinal Study

(2019) Nardhy Gomez-Lopez et al.   Frontiers in Immunology

Biologic mechanisms and clinical consequences of pregnancy alloimmunization

(2018) Paige M. Porrett   AMERICAN JOURNAL OF TRANSPLANTATION

Deep Surveying of the Transcriptional and Alternative Splicing Signatures for Decidual CD8+ T Cells at the First Trimester of Human Healthy Pregnancy

(2018) Weihong Zeng et al.   Frontiers in Immunology

Meta-Analysis of Maternal and Fetal Transcriptomic Data Elucidates the Role of Adaptive and Innate Immunity in Preterm Birth

(2018) Bianca Vora et al.   Frontiers in Immunology

Regulatory T cells in embryo implantation and the immune response to pregnancy

(2018) Sarah A. Robertson et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN

(2017) Richard M. Powell et al.   JOURNAL OF IMMUNOLOGY

Pregnancy-Induced Sensitization Promotes Sex Disparity in Living Donor Kidney Transplantation

(2017) Bianca Bromberger et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mixed signature of activation and dysfunction allows human decidual CD8+T cells to provide both tolerance and immunity

(2017) Anita van der Zwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells

(2017) Thomas C. J. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Transcriptional and Alternative Splicing Signatures of Decidual CD4+ T Cells in Early Human Pregnancy

(2017) Weihong Zeng et al.   Frontiers in Immunology

Pregnancy promotes tolerance to future offspring by programming selective dysfunction in long-lived maternal T cells

(2016) Brendan M. Barton et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors

(2016) Lokesh A Kalekar et al.   NATURE IMMUNOLOGY

Placental exosomes in normal and complicated pregnancy

(2015) Murray D. Mitchell et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Tissue microchimerism is increased during pregnancy: a human autopsy study

(2015) Emilie C. Rijnink et al.   MOLECULAR HUMAN REPRODUCTION

Evidence for a Selective Migration of Fetus-Specific CD4+CD25bright Regulatory T Cells from the Peripheral Blood to the Decidua in Human Pregnancy

(2014) T. Tilburgs et al.   JOURNAL OF IMMUNOLOGY

Cis-Acting Pathways Selectively Enforce the Non-Immunogenicity of Shed Placental Antigen for Maternal CD8 T Cells

(2014) Chin-Siean Tay et al.   PLoS One

Frequency and Determinants of Pregnancy-Induced Child-Specific Sensitization

(2013) G. Hönger et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

(2012) Robert M. Samstein et al.   CELL

Fetal-Specific CD8+ Cytotoxic T Cell Responses Develop during Normal Human Pregnancy and Exhibit Broad Functional Capacity

(2012) D. Lissauer et al.   JOURNAL OF IMMUNOLOGY

Pregnancy imprints regulatory memory that sustains anergy to fetal antigen

(2012) Jared H. Rowe et al.   NATURE

Chemokine Gene Silencing in Decidual Stromal Cells Limits T Cell Access to the Maternal-Fetal Interface

(2012) P. Nancy et al.   SCIENCE

Foxp3+ Regulatory T Cell Expansion Required for Sustaining Pregnancy Compromises Host Defense against Prenatal Bacterial Pathogens

(2011) Jared H. Rowe et al.   Cell Host & Microbe

Immunology of Pre-Eclampsia

(2010) Christopher W. G. Redman et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Human Decidual Tissue Contains Differentiated CD8+ Effector-Memory T Cells with Unique Properties

(2010) T. Tilburgs et al.   JOURNAL OF IMMUNOLOGY

Cross-Presentation of Male Seminal Fluid Antigens Elicits T Cell Activation to Initiate the Female Immune Response to Pregnancy

(2009) L. M. Moldenhauer et al.   JOURNAL OF IMMUNOLOGY

Fetal–maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells

(2009) Tamara Tilburgs et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Expression of NK cell receptors on decidual T cells in human pregnancy

(2009) Tamara Tilburgs et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Decidual leucocyte populations in early to late gestation normal human pregnancy

(2009) P.J. Williams et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies

(2008) Richard Apps et al.   IMMUNOLOGY