Article
Gastroenterology & Hepatology
Katherine Duffey, Dina Halegoua-DeMarzio, Ashesh P. Shah, Danielle M. Tholey
Summary: This study aims to examine sex and racial disparities in living donor liver transplantation (LDLT) in the US population. The results show significant disparities in sex and race in LDLT, disadvantaging women, but these disparities are less pronounced than in deceased donor liver transplantation (DDLT). Further research is needed to better understand the factors contributing to these variations.
LIVER TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Patrick Ahearn, Kirsten L. Johansen, Jane C. Tan, Charles E. McCulloch, Barbara A. Grimes, Elaine Ku
Summary: Women with kidney failure have lower access to kidney transplantation compared with men, especially notable among patients with kidney failure attributed to diabetes, while sex disparities in access to either the waitlist or transplantation were not observed in kidney failure secondary to cystic disease.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Surgery
Austin D. Schenk, April J. Logan, Jeffrey M. Sneddon, Daria Faulkner, Jing L. Han, Guy N. Brock, William K. Washburn
Summary: This study examined the outcomes of living donor and deceased donor kidney transplant recipients in terms of Textbook Outcomes (TO). It was found that patients who experienced TO had superior long-term survival, adding value to the current standards of 1-year patient and graft survival. Additionally, the study identified specific centers under-performing in kidney transplantation outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Urology & Nephrology
Takahisa Hiramitsu, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Yutaka Matsuoka, Norihiko Goto, Toshihiro Ichimori, Shunji Narumi, Asami Takeda, Takaaki Kobayashi, Kazuharu Uchida, Yoshihiko Watarai
Summary: This study investigated the impact of age differences between older adult living donors and recipients on kidney transplantation outcomes. The results showed that kidney transplants from older adult donors to older adult recipients had the highest risk of graft loss and mortality, with recipients having lower estimated glomerular filtration rates.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Urology & Nephrology
Siah Kim, Anita van Zwieten, Melanie Wyld, Maleeka Ladhani, Chandana Guha, Amanda Dominello, Kylie-Ann Mallitt, Anna Francis, Roslyn B. Mannon, Germaine Wong
Summary: Based on data from Australia and New Zealand, females constitute a larger proportion of kidney donors to male recipients. The relationship between recipient and donor is a factor that modifies the association between recipient gender and donor gender. Older recipients residing in remote areas are more likely to receive kidneys from female donors.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Biochemistry & Molecular Biology
G. J. Julia Huisman, Nora A. Spraakman, Jeroen V. Koomen, A. Marrit Talsma, Robert A. Pol, Stefan P. Berger, Henri G. D. Leuvenink, Michel M. R. F. Struys, Gertrude J. Nieuwenhuijs-Moeke
Summary: Early non-invasive detection and prediction of graft function after kidney transplantation is important. The study analyzed four urinary biomarkers and found that KIM-1 and NAG at early timepoints after transplantation were significant predictors for eGFR, while NGAL and NAG at day 1 after transplantation were negative predictors. Including these biomarkers improved the prediction models for graft outcome. Factors such as timing of measurement and transplantation factors need to be considered when using urinary biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
L. Ebony Boulware, Debra L. Sudan, Tara S. Strigo, Patti L. Ephraim, Clemontina A. Davenport, Jane F. Pendergast, Iris Pounds, Jennie A. Riley, Margaret Falkovic, Aviel Alkon, Felicia Hill-Briggs, Ashley N. Cabacungan, Tyler M. Barrett, Dinushika Mohottige, Lisa McElroy, Clarissa J. Diamantidis, Matthew J. Ellis
Summary: The study found limited effectiveness of a transplant social worker intervention and financial assistance in activating potential donors among African Americans on the transplant waiting list.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Fan Zhang, Saifu Yin, Yu Fan, Turun Song, Zhongli Huang, Jiayu Liang, Jiapei Wu, Youmin Yang, Tao Lin, Xianding Wang
Summary: This study found that the secretor status of both donors and recipients may have an impact on the outcomes of ABO incompatibility kidney transplantation. Recipients with weak secretor status may have better post-transplant renal function, while recipients from secretor donors had a lower incidence of graft rejection in the first year after transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Elaine Ku, Sandra Amaral, Charles E. McCulloch, Deborah B. Adey, Libo Li, Kirsten L. Johansen
Summary: This study examines whether using the 2021 CKD-EPI equation can reduce racial differences in preemptive wait time for kidney transplantation.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Surgery
Robin K. Avery, Jennifer D. Motter, Kyle R. Jackson, Robert A. Montgomery, Allan B. Massie, Edward S. Kraus, Kieren A. Marr, Bonnie E. Lonze, Nada Alachkar, Mary J. Holechek, Darin Ostrander, Niraj Desai, Madeleine M. Waldram, Shmuel Shoham, Seema Mehta Steinke, Aruna Subramanian, Janet M. Hiller, Julie Langlee, Sheila Young, Dorry L. Segev, Jacqueline M. Garonzik Wang
Summary: Desensitization for incompatible living donor kidney transplantation increases the risk of infections, especially in highly desensitized recipients, leading to prolonged hospitalization and graft loss. Strategies are needed to protect patients from recurrent infections and extend the survival benefit of ILDKT.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Nutrition & Dietetics
Kao-Ming Hsu, Pei-Ru Lin, Ping-Fang Chiu, Yao-Peng Hsieh
Summary: This study investigated the subsequent renal function change following incident infectious diseases in living-donor liver transplant recipients. The results showed that hospitalization with major infections or pneumonia increased the risk of eGFR decline and adverse renal outcomes in these patients.
Article
Surgery
Michael Darden, Geoff Parker, Edward Anderson, Joseph F. Buell
Summary: Studies show sex disparities in liver transplantation rates. 19% of the disparity can be explained by differences in size between men and women. Transplantation rates vary between genders increase with the ratio of male-to-female height and weight.
Article
Medicine, General & Internal
Martina Cozzi, Paola Donato, Gabriele Ugolini, Rostand Emmanuel Nguefouet Momo, Francesco Nacchia, Zeno Ballarini, Pierluigi Piccoli, Maurizio Cantini, Chiara Caletti, Stefano Andreola, Giorgio Gandini, Giovanni Gambaro, Luigino Boschiero
Summary: AB0 incompatible living donor kidney transplantation (AB0i LDKT) is an effective therapeutic strategy with graft function and survival comparable to compatible living donor kidney transplantation (AB0c LDKT), despite higher rates of acute rejection and sepsis. It provides an additional opportunity for patients with blood group 0.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Jun Young Lee, Sung Hwan Cha, Sung Hwa Kim, Kyung Hwan Jeong, Ku Yong Chung, Hong Rae Cho, Juhan Lee, Kyu Ha Huh, Jaeseok Yang, Myoung Soo Kim, Deok Gie Kim
Summary: The combination of ABO incompatibility and donor-recipient weight mismatch is an independent risk factor for graft and patient survival in living donor kidney transplantation, leading to an increased risk of pneumonia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Stijn C. van de Laar, Matthew L. Robb, Rachel Hogg, Lisa Burnapp, Vassilios E. Papalois, Frank J. M. F. Dor
Summary: The study found that LDKT performed within the UKLKSS had longer cold ischaemia time, higher incidence of delayed graft function, and lower graft function compared to the non-KEP group, but excellent 5-year graft survival similar to non-KEP was observed.
Article
Immunology
Sohaib Khalid Hashmi, Esther Baranov, Ana Gonzalez, Kim Olthoff, Abraham Shaked
TRANSPLANTATION REVIEWS
(2015)
Article
Gastroenterology & Hepatology
Paige M. Porrett, Sohaib K. Hashmi, Abraham Shaked
CLINICS IN LIVER DISEASE
(2014)
Article
Multidisciplinary Sciences
Feng Liu, Alexander H. Morrison, Thomas Gregor
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Multidisciplinary Sciences
Alexander H. Morrison, Mark S. Diamond, Ceire A. Hay, Katelyn T. Byrne, Robert H. Vonderheide
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Medicine, Research & Experimental
Sohaib Khalid Hashmi, Vasia Barka, Changsong Yang, Sabine Schneider, Tatyana M. Syitkina, Robert O. Heuckeroth
Review
Gastroenterology & Hepatology
Sohaib Khalid Hashmi, Rachel Helen Ceron, Robert O. Heuckeroth
Summary: Visceral smooth muscle is crucial for the movement of hollow organs and has unique properties that facilitate strong contraction and dilation. Visceral myopathies, such as MMIHS and myopathic CIPO, are caused by mutations in cytoskeletal proteins and can lead to severe dysfunction in bowel, bladder, and uterus, with potential fatal consequences.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Transplantation
Alexander H. Morrison, Meera Gupta, Kelsey Lloyd, Jennifer Trofe-Clark, Mary Ann Lim, Christine Limonte, Matthew H. Levine, Deirdre Sawinski, Malek Kamoun, Paige M. Porrett
TRANSPLANTATION DIRECT
(2019)
Review
Oncology
Alexander H. Morrison, Katelyn T. Byrne, Robert H. Vonderheide
Proceedings Paper
Engineering, Biomedical
S. K. Hashmi, S. Sullivan, S. A. Eucker, B. Coats, J. Lee, S. S. Margulies
2012 38TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE (NEBEC)
(2012)