Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function

Calcium Signaling in the Oligodendrocyte Lineage: Regulators and Consequences

(2020) Pablo M. Paez et al.   Annual Review of Neuroscience

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory

(2020) Fei Wang et al.   NATURE NEUROSCIENCE

Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation

(2020) Roberta Marisca et al.   NATURE NEUROSCIENCE

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

(2020) Corina Nagy et al.   NATURE NEUROSCIENCE

Sex-specific differences in transcriptomic profiles and cellular characteristics of oligodendrocyte precursor cells

(2020) Ken Yasuda et al.   Stem Cell Research

Unraveling Myelin Plasticity

(2020) Giulia Bonetto et al.   Frontiers in Cellular Neuroscience

Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer's disease

(2020) Ilaria Vanzulli et al.   NEUROBIOLOGY OF AGING

Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

(2019) Sonia Olivia Spitzer et al.   NEURON

Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages

(2019) Dogukan Mizrak et al.   Cell Reports

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

(2019) Brandon Farmer et al.   Cells

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

(2019) Parysatis Sachs et al.   Nature Communications

Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play

(2019) Jonathan W. VanRyzin et al.   NEURON

Altered human oligodendrocyte heterogeneity in multiple sclerosis

(2019) Sarah Jäkel et al.   NATURE

Dynamics of oligodendrocyte generation in multiple sclerosis

(2019) Maggie S. Y. Yeung et al.   NATURE

Early embryonic NG2 glia are exclusively gliogenic and do not generate neurons in the brain

(2019) Wenhui Huang et al.   GLIA

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis

(2019) Qinjie Weng et al.   Cell Stem Cell

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Aberrant oligodendroglial–vascular interactions disrupt the blood–brain barrier, triggering CNS inflammation

(2019) Jianqin Niu et al.   NATURE NEUROSCIENCE

Molecular Control of Oligodendrocyte Development

(2019) Benayahu Elbaz et al.   TRENDS IN NEUROSCIENCES

Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases?

(2019) Lay Kodama et al.   TRENDS IN MOLECULAR MEDICINE

Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex

(2019) Marzieh Zonouzi et al.   Cell Reports

The active contribution of OPCs to neuroinflammation is mediated by LRP1

(2019) Anthony Fernández-Castañeda et al.   ACTA NEUROPATHOLOGICA

Modeling Alzheimer’s disease with iPSC-derived brain cells

(2019) Jay Penney et al.   MOLECULAR PSYCHIATRY

Quetiapine has an additive effect to triiodothyronine in inducing differentiation of oligodendrocyte precursor cells through induction of cholesterol biosynthesis

(2019) Jaime Gonzalez Cardona et al.   PLoS One

NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis

(2019) Shu-zhen Zhang et al.   BMC Medicine

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

(2019) Björn Neumann et al.   Cell Stem Cell

Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis

(2019) David Orduz et al.   Nature Communications

Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity

(2019) Christopher W Mount et al.   eLife

Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair

(2018) Chuntao Zhao et al.   DEVELOPMENTAL CELL

Immunology of oligodendrocyte precursor cells in vivo and in vitro

(2018) Jack P. Antel et al.   JOURNAL OF NEUROIMMUNOLOGY

The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog

(2018) Caitlin C Winkler et al.   JOURNAL OF NEUROSCIENCE

The senescent bystander effect is caused by ROS-activated NF-κB signalling

(2018) Glyn Nelson et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

(2018) Axel Montagne et al.   NATURE MEDICINE

Defective cholesterol clearance limits remyelination in the aged central nervous system

(2018) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

(2018) Seiji Kaji et al.   Stem Cell Reports

Sequentially acting SOX proteins orchestrate astrocyte‐ and oligodendrocyte‐specific gene expression

(2018) Susanne Klum et al.   EMBO REPORTS

Activity-dependent central nervous system myelination throughout life

(2018) Omar de Faria et al.   JOURNAL OF NEUROCHEMISTRY

Molecular and genetic evidence for the PDGFRα-independent population of OPCs in the developing mouse brain

(2018) Kang Zheng et al.   JOURNAL OF NEUROSCIENCE

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

(2018) Ana Mendanha Falcão et al.   NATURE MEDICINE

Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity

(2017) Richa Hanamsagar et al.   GLIA

Oligodendroglia: metabolic supporters of neurons

(2017) Thomas Philips et al.   JOURNAL OF CLINICAL INVESTIGATION

Myelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury

(2017) Peggy Assinck et al.   JOURNAL OF NEUROSCIENCE

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage

(2017) Mark A. Petersen et al.   NEURON

The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke

(2017) Elisabetta Bonfanti et al.   Cell Death & Disease

Differentiation of Oligodendrocyte Precursor Cells from Sox10-Venus Mice to Oligodendrocytes and Astrocytes

(2017) Nobuharu Suzuki et al.   Scientific Reports

Remarkable Stability of Myelinating Oligodendrocytes in Mice

(2017) Richa B. Tripathi et al.   Cell Reports

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

(2017) Alerie Guzman De La Fuente et al.   Cell Reports

Age-Related Gray and White Matter Changes in Normal Adult Brains

(2017) Farnaz Farokhian et al.   Aging and Disease

NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival

(2017) Masayuki Nakano et al.   Scientific Reports

Antioxidant Protection of NADPH-Depleted Oligodendrocyte Precursor Cells Is Dependent on Supply of Reduced Glutathione

(2016) Ewa Kilanczyk et al.   ASN Neuro

Adult oligodendrocyte progenitor cells – Multifaceted regulators of the CNS in health and disease

(2016) Anthony Fernandez-Castaneda et al.   BRAIN BEHAVIOR AND IMMUNITY

The immunomodulatory oligodendrocyte

(2016) Thomas Zeis et al.   BRAIN RESEARCH

Adult NG2-Glia Are Required for Median Eminence-Mediated Leptin Sensing and Body Weight Control

(2016) Tina Djogo et al.   Cell Metabolism

The environment rules: spatiotemporal regulation of oligodendrocyte differentiation

(2016) Sonia R Mayoral et al.   CURRENT OPINION IN NEUROBIOLOGY

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

(2016) H.-H. Tsai et al.   SCIENCE

Ageing and brain white matter structure in 3,513 UK Biobank participants

(2016) Simon R. Cox et al.   Nature Communications

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

(2016) Sona Hubackova et al.   Aging-US

Voltage-gated Ca++ entry promotes oligodendrocyte progenitor cell maturation and myelination in vitro

(2015) V.T. Cheli et al.   EXPERIMENTAL NEUROLOGY

Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration

(2015) S. Moyon et al.   JOURNAL OF NEUROSCIENCE

Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development

(2015) J. Dai et al.   JOURNAL OF NEUROSCIENCE

A functional progesterone receptor is required for immunomodulation, reduction of reactive gliosis and survival of oligodendrocyte precursors in the injured spinal cord

(2015) Florencia Labombarda et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2

(2015) Fikri Birey et al.   NEURON

Potential interactions between pericytes and oligodendrocyte precursor cells in perivascular regions of cerebral white matter

(2015) Takakuni Maki et al.   NEUROSCIENCE LETTERS

Oligodendrocytes in a Nutshell

(2015) John-Paul Michalski et al.   Frontiers in Cellular Neuroscience

Oligodendrocyte Development and Plasticity

(2015) Dwight E. Bergles et al.   Cold Spring Harbor Perspectives in Biology

Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System

(2015) Ben Emery et al.   Cold Spring Harbor Perspectives in Biology

Interneurons and oligodendrocyte progenitors form a structured synaptic network in the developing neocortex

(2015) David Orduz et al.   eLife

NG2 glia are required for vessel network formation during embryonic development

(2015) Shilpi Minocha et al.   eLife

Diverse subtypes of astrocytes and their development during corticogenesis

(2015) Hidenori Tabata   Frontiers in Neuroscience

Oligodendrocyte Precursor Cells Synthesize Neuromodulatory Factors

(2015) Dominik Sakry et al.   PLoS One

Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination and White Matter Angiogenesis

(2014) Tracy J. Yuen et al.   CELL

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development

(2014) Wenhui Huang et al.   GLIA

Migration of Oligodendrocyte Progenitor Cells Is Controlled by Transforming Growth Factor   Family Proteins during Corticogenesis

(2014) Y. Choe et al.   JOURNAL OF NEUROSCIENCE

TGF  Signaling Regulates the Timing of CNS Myelination by Modulating Oligodendrocyte Progenitor Cell Cycle Exit through SMAD3/4/FoxO1/Sp1

(2014) J. Palazuelos et al.   JOURNAL OF NEUROSCIENCE

Oligodendrocyte Precursor Cells Support Blood-Brain Barrier Integrity via TGF-β Signaling

(2014) Ji Hae Seo et al.   PLoS One

Modulating neurotoxicity through CX3CL1/CX3CR1 signaling

(2014) Cristina Limatola et al.   Frontiers in Cellular Neuroscience

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

(2014) Takahisa Kanekiyo et al.   Frontiers in Aging Neuroscience

Oligodendrocyte Precursor Cells Modulate the Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2

(2014) Dominik Sakry et al.   PLOS BIOLOGY

Attenuation of Corpus Callosum Axon Myelination and Remyelination in the Absence of Circulating Sex Hormones

(2013) Rhusheet Patel et al.   BRAIN PATHOLOGY

Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation

(2013) Yang Yu et al.   CELL

A functional role of NMDA receptor in regulating the differentiation of oligodendrocyte precursor cells and remyelination

(2013) Cui Li et al.   GLIA

Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury

(2013) Ji Hae Seo et al.   JOURNAL OF CLINICAL INVESTIGATION

Oligodendrocyte Precursor Cells Are Accurate Sensors of Local K+ in Mature Gray Matter

(2013) P. P. Maldonado et al.   JOURNAL OF NEUROSCIENCE

Act1 mediates IL-17–induced EAE pathogenesis selectively in NG2+ glial cells

(2013) Zizhen Kang et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain

(2013) Ethan G Hughes et al.   NATURE NEUROSCIENCE

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling

(2013) Kaylene M. Young et al.   NEURON

Evidence for NG2-glia Derived, Adult-Born Functional Neurons in the Hypothalamus

(2013) Sarah C. Robins et al.   PLoS One

NG2 cells, a new trail for Alzheimer’s disease mechanisms?

(2013) Henrietta M Nielsen et al.   Acta Neuropathologica Communications

Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation

(2012) J Boren et al.   CELL DEATH AND DIFFERENTIATION

Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development

(2012) M. Cristina Ortega et al.   EXPERIMENTAL NEUROLOGY

TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment

(2012) Shai Abutbul et al.   GLIA

Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis

(2012) Yuan Yuan et al.   Protein & Cell

Class 3 semaphorins influence oligodendrocyte precursor recruitment and remyelination in adult central nervous system

(2011) Gabrièle Piaton et al.   BRAIN

Age-dependent fate and lineage restriction of single NG2 cells

(2011) X. Zhu et al.   DEVELOPMENT

Fate of neuron-glia synapses during proliferation and differentiation of NG2 cells

(2011) Nicole Fröhlich et al.   JOURNAL OF ANATOMY

Sex differences in microglial colonization of the developing rat brain

(2011) Jaclyn M. Schwarz et al.   JOURNAL OF NEUROCHEMISTRY

Fibroblast Growth Factor Signaling Is Required for the Generation of Oligodendrocyte Progenitors from the Embryonic Forebrain

(2011) M. Furusho et al.   JOURNAL OF NEUROSCIENCE

Oligodendrocyte Progenitors Reversibly Exit the Cell Cycle and Give Rise to Astrocytes in Response to Interferon- 

(2011) D. C. Tanner et al.   JOURNAL OF NEUROSCIENCE

Reactive Astrocytes Inhibit the Survival and Differentiation of Oligodendrocyte Precursor Cells by Secreted TNF-α

(2011) Zhida Su et al.   JOURNAL OF NEUROTRAUMA

NG2-glia as Multipotent Neural Stem Cells: Fact or Fantasy?

(2011) William D. Richardson et al.   NEURON

Gray Matter NG2 Cells Display Multiple Ca2+-Signaling Pathways and Highly Motile Processes

(2011) Christian Haberlandt et al.   PLoS One

CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

(2010) Malgorzata Zawadzka et al.   Cell Stem Cell

Regulation of L-type Ca++ currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteins

(2010) Daniel Fulton et al.   GLIA

Postnatal Switch from Synaptic to Extrasynaptic Transmission between Interneurons and NG2 Cells

(2010) M. Velez-Fort et al.   JOURNAL OF NEUROSCIENCE

Pyramidal Neurons Are Generated from Oligodendroglial Progenitor Cells in Adult Piriform Cortex

(2010) F. Guo et al.   JOURNAL OF NEUROSCIENCE

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

(2010) Shin H. Kang et al.   NEURON

MicroRNA-Mediated Control of Oligodendrocyte Differentiation

(2010) Xianghui Zhao et al.   NEURON

Lipid droplets in inflammation and cancer

(2010) Patricia T. Bozza et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Regulation of Oligodendrocyte Differentiation and Myelination

(2010) B. Emery   SCIENCE

Oligodendrocytes: biology and pathology

(2009) Monika Bradl et al.   ACTA NEUROPATHOLOGICA

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

NG2 and phosphacan are present in the astroglial scar after human traumatic spinal cord injury

(2009) Armin Buss et al.   BMC Neurology

Astrocytes and oligodendrocytes can be generated from NG2+progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice

(2009) Jing-Wei Zhao et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Gender and sex hormones in multiple sclerosis pathology and therapy

(2009) Arnaud Nicot   Frontiers in Bioscience-Landmark

Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2-glia

(2009) Nicola Hamilton et al.   GLIA

An Oligovascular Niche: Cerebral Endothelial Cells Promote the Survival and Proliferation of Oligodendrocyte Precursor Cells

(2009) K. Arai et al.   JOURNAL OF NEUROSCIENCE

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

(2009) Jessica A. Cardin et al.   NATURE

The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination

(2009) Ying Chen et al.   NATURE NEUROSCIENCE

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

(2009) Feng Ye et al.   NATURE NEUROSCIENCE

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligodendrocyte development and the onset of myelination in the human fetal brain

(2009) Igor Jakovcevski   Frontiers in Neuroanatomy

Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases

(2009) Todd E Golde et al.   Alzheimers Research & Therapy

Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor   expression

(2008) M. Finzsch et al.   DEVELOPMENT

Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury

(2008) Florencia Labombarda et al.   GLIA

Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex

(2008) L. Dimou et al.   JOURNAL OF NEUROSCIENCE

Genetic fate mapping of Olig2 progenitors in the injured adult cerebral cortex reveals preferential differentiation into astrocytes

(2008) Kouko Tatsumi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

(2008) Leanne E Rivers et al.   NATURE NEUROSCIENCE

Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter

(2008) Ragnhildur Káradóttir et al.   NATURE NEUROSCIENCE

Distinct Stages of Myelination Regulated by γ-Secretase and Astrocytes in a Rapidly Myelinating CNS Coculture System

(2008) Trent A. Watkins et al.   NEURON

Dividing glial cells maintain differentiated properties including complex morphology and functional synapses

(2008) W.-P. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA