Apelin-13 induces mitophagy in bone marrow mesenchymal stem cells to suppress intracellular oxidative stress and ameliorate osteoporosis by activation of AMPK signaling pathway

Apelin/APJ system: an emerging therapeutic target for respiratory diseases

(2020) Jialong Yan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

P53 and Parkin co-regulate mitophagy in bone marrow mesenchymal stem cells to promote the repair of early steroid-induced osteonecrosis of the femoral head

(2020) Fei Zhang et al.   Cell Death & Disease

Blueberry Juice Antioxidants Protect Osteogenic Activity against Oxidative Stress and Improve Long-Term Activation of the Mineralization Process in Human Osteoblast-Like SaOS-2 Cells: Involvement of SIRT1

(2020) Vladana Domazetovic et al.   Antioxidants

Desferoxamine protects against glucocorticoid‐induced osteonecrosis of the femoral head via activating HIF‐1α expression

(2020) Xingzhi Jing et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Apelin-13 attenuates high glucose-induced calcification of MOVAS cells by regulating MAPKs and PI3K/AKT pathways and ROS-mediated signals

(2020) Pu Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Vitamin K2 Can Rescue the Dexamethasone-Induced Downregulation of Osteoblast Autophagy and Mitophagy Thereby Restoring Osteoblast Function In Vitro and In Vivo

(2020) Liang Chen et al.   Frontiers in Pharmacology

A requirement for PAK1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis

(2020) Miwon Ahn et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling

(2019) Jialin Duan et al.   Journal of Neuroinflammation

Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases

(2019) Rocío M. de Pablos et al.   PHARMACOLOGICAL RESEARCH

Absence of Dipeptidyl Peptidase 3 increases oxidative stress and causes bone loss

(2019) Ciro Menale et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mitophagy is a protective response against oxidative damage in bone marrow mesenchymal stem cells

(2019) Pan Fan et al.   LIFE SCIENCES

AKT-GSK3β Signaling Pathway Regulates Mitochondrial Dysfunction-Associated OPA1 Cleavage Contributing to Osteoblast Apoptosis: Preventative Effects of Hydroxytyrosol

(2019) W. J. Cai et al.   Oxidative Medicine and Cellular Longevity

Apelin enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly through Wnt/β-catenin signaling pathway

(2019) Kai Hang et al.   Stem Cell Research & Therapy

Plasma Apelin and Risk of Type 2 Diabetes in a Cohort From the Community

(2019) Isabelle Castan-Laurell et al.   DIABETES CARE

Imperatorin promotes osteogenesis and suppresses osteoclast by activating AKT/GSK3 β/β‐catenin pathways

(2019) De‐Yi Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats

(2019) Weilin Xu et al.   Journal of Neuroinflammation

Post-translational Modifications of Key Machinery in the Control of Mitophagy

(2019) Liming Wang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Apelin-13 deficiency alters cortical bone geometry, organic bone matrix, and inhibits Wnt/β-catenin signaling

(2018) Xiao-fang Han et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Anti-osteoporosis activity of Sanguinarine in preosteoblast MC3T3-E1 cells and an ovariectomized rat model

(2018) Fuzhan Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role of mitochondria

(2018) Yulai Shen et al.   Particle and Fibre Toxicology

Apelin-13 Administration Protects Against LPS-Induced Acute Lung Injury by Inhibiting NF-κB Pathway and NLRP3 Inflammasome Activation

(2018) Hailin Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

PINK1/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPKα and exacerbates atherosclerotic lesions

(2018) Lu He et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Icariin protects against iron overload-induced bone loss via suppressing oxidative stress

(2018) Xingzhi Jing et al.   JOURNAL OF CELLULAR PHYSIOLOGY

European guidance for the diagnosis and management of osteoporosis in postmenopausal women

(2018) J.A. Kanis et al.   OSTEOPOROSIS INTERNATIONAL

Mitochondria and cellular senescence: Implications for musculoskeletal ageing

(2018) Leena Habiballa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Apelin Is a Negative Regulator of Angiotensin II–Mediated Adverse Myocardial Remodeling and DysfunctionNovelty and Significance

(2017) Zhen-Zhou Zhang et al.   HYPERTENSION

The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells

(2017) Qianqian Li et al.   Protein & Cell

Activation of GLP-1 Receptor Promotes Bone Marrow Stromal Cell Osteogenic Differentiation through β-Catenin

(2016) Jingru Meng et al.   Stem Cell Reports

Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones

(2015) Andrea L. Frump et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The role of leptin in regulating bone metabolism

(2015) Jagriti Upadhyay et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Activation of AMPK participates hydrogen sulfide-induced cyto-protective effect against dexamethasone in osteoblastic MC3T3-E1 cells

(2014) Ming Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR

(2014) Nigel A. Chapman et al.   Biochemistry and Cell Biology

Oxidative damage to osteoblasts can be alleviated by early autophagy through the endoplasmic reticulum stress pathway—Implications for the treatment of osteoporosis

(2014) Yue-Hua Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

P53 Dependent Mitochondrial Permeability Transition Pore Opening Is Required for Dexamethasone-Induced Death of Osteoblasts

(2014) Yun-fang Zhen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Apelin protects sarcoplasmic reticulum function and cardiac performance in ischaemia-reperfusion by attenuating oxidation of sarcoplasmic reticulum Ca2+-ATPase and ryanodine receptor

(2013) Chen Wang et al.   CARDIOVASCULAR RESEARCH

Individualizing osteoporosis therapy

(2012) S. Silverman et al.   OSTEOPOROSIS INTERNATIONAL

Osteoporosis: now and the future

(2011) Tilman D Rachner et al.   LANCET

Protective effect of apelin on cultured rat bone marrow mesenchymal stem cells against apoptosis

(2011) Xiangjun Zeng et al.   Stem Cell Research

Bone loss caused by iron overload in a murine model: importance of oxidative stress

(2010) J. Tsay et al.   BLOOD

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

(2010) Stavros C. Manolagas   ENDOCRINE REVIEWS

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oxidative stress, free radicals and bone remodeling

(2008) Giuseppe Banfi et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE