Article
Chemistry, Analytical
Xue-Lian Jiang, Yao Zhu, Gai-Fan Ma, Ping Liu, Lin-Lin Chen
Summary: The overall chemical profile of Renshen-Yangrong Pill (RYP), a traditional Chinese medicine, was investigated using UPLC-LTQ/Orbitrap/MS, and the quantitative distributions of representative components in the preparation were obtained. A total of 132 components were identified or characterized, with hesperidin and paeoniflorin being the most abundant constituents. This study provides valuable insights into the chemical composition of RYP and lays a foundation for further exploration of its effective components and quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Applied
Hong Duan, Wei Wang, Yongxiang Li, Ghulam Jilany Khan, Yuan Chen, Tianci Shen, Nina Bao, Jing Hua, Zhenglian Xue, Kefeng Zhai, Zhaojun Wei
Summary: The study identified 18 compounds in the stem of Premna microphylla Turcz., with 6 compounds being identified for the first time within this genus and plant. These compounds highlight the strong therapeutic potential of Premna microphylla Turcz. stem extract against oxidation-related diseases.
Article
Pharmacology & Pharmacy
Xiaofan Chen, Jiahui Zhang, Rui Li, Hua Zhang, Yong Sun, Li Jiang, Xiaoya Wang, Yaokun Xiong
Summary: This study demonstrates that extracts from Flos Puerariae and Semen Hoveniae (PHE) can effectively alleviate DSS-induced colitis through inhibition of inflammatory reactions, restoration of antioxidant enzyme activity, and modulation of gut microbiota composition.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Huanhuan Wang, Liying Tang, Shaowei Hu, Xixian Kong, Yi Ouyang, Dong Zhang, Yi Zhang, Shihuan Tang, Hongwei Wu, Hongjun Yang
Summary: This study revealed the ingredients, tissue distribution, and pharmacokinetic characteristics of Shengmai injection (SMI). The study found that ginsenosides were the main active compounds in SMI and had high exposure in different tissues. The pharmacokinetic evaluation showed different elimination rates for different types of ginsenosides.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Chemistry, Multidisciplinary
Zhenzhong Zang, Shichun Zhao, Ming Yang, Chengqun Yu, Hui Ouyang, Lihua Chen, Weifeng Zhu, Zheng-gen Liao, Abid Naeem, Yongmei Guan
Summary: This study investigated the composition and in vivo absorption of active components in honeysuckle and developed a controlled release hydrogel system. The results showed that 42 components, including flavonoids, iridoids, organic acids, and other compounds, were absorbed into the blood. The prepared hydrogels demonstrated high thermal stability and maximum swelling and drug release at pH 7.4.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Li Sun, You Su, Kaiyin Hu, Daxiang Li, Huimin Guo, Zhongwen Xie
Summary: In this study, the biotransferred metabolites of the primary bioactive components in black tea, theaflavins (TFs), produced by the human gut microbiota were investigated. A total of 17 microbial metabolites were identified, and their corresponding metabolic pathways were proposed. Furthermore, it was found that TFs changed the gut microbiota diversity and increased the relative abundance of specific members involved in the catabolism of TFs. Notably, the antioxidant capacity of TFs increased after fermentation compared to the initial sample.
Article
Chemistry, Applied
Chagam Koteswara Reddy, Su Young Son, Choong Hwan Lee
Summary: The study demonstrates that debranched maize starch can form inclusion complexes with catechin-rich green tea ethanolic extract, showing high recovery yield and stability.
FOOD HYDROCOLLOIDS
(2021)
Article
Plant Sciences
Xiaoya Wang, Kejun Cheng, Zhiyong Liu, Yong Sun, Lifen Zhou, Mengtian Xu, Xiuxiu Dai, Yaokun Xiong, Hua Zhang
Summary: The study revealed that the extract of Mosla chinensis Maxim. cv. Jiangxiangru has anti-inflammatory and antioxidant properties, showing potential therapeutic effects on inflammatory bowel disease.
Article
Biology
Wanli Ji, Tingting Wang, Yanwen Xu, Rui An, Kun Liang, Xinhong Wang
Summary: In this study, the targets and active compounds of Banxia Xiexin decoction (BXD) in the treatment of chronic gastritis were predicted using network pharmacology. The results showed that BXD exhibited therapeutic effects in ethanol-induced gastritis through multi-compound, multi-target, and multi-pathway mechanisms. Additionally, enrichment analysis revealed that BXD primarily involves cytokine activation, inflammatory response, and various signaling pathways in the treatment of chronic gastritis.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jiajin Huang, Lijun Ding, Wenyue Tian, Hui Zhi, Jing Chen, Liangcai Wu, Likang Wang, Juntao Xie, Jingyan Bai, Hongxia Fan, Suqing Zhao, Kun Zhang, Junxia Zheng
Summary: In this study, the polyphenolic profile of Mesona chinensis Benth (MCB) was determined using UPLC-Q-TOF-MS/MS, identifying a total of 57 compounds including 45 polyphenols. Among them, 23 phytochemicals were identified in MCB for the first time. The antioxidant activities were found to be positively correlated with the polyphenolic levels, with MCB produced in Guangdong Raoping showing the best antioxidant activity and strongest inhibitory effect on alpha-glucosidase.
MICROCHEMICAL JOURNAL
(2021)
Article
Plant Sciences
Irena Brcic Karaconji, Karlo Jurica, Uros Gasic, Aleksandra Dramicanin, Zivoslav Tesic, Dusanka Milojkovic Opsenica
Summary: This study compared the phenolic profiles, total phenolic content, and radical scavenging activity of strawberry tree leaves and fruits collected in two locations in Croatia. The results showed that both leaves and fruits contained a wide range of phenolic compounds and exhibited strong antioxidant activity, indicating the potential health-promoting properties of the strawberry tree.
Article
Agriculture, Multidisciplinary
Fanghua Guo, Rong Tsao, Xiaoya Wang, Li Jiang, Yong Sun, Hua Xiong
Summary: The study analyzed the chemical profiles, metabolites, and organ distribution of yellow pea hull (YPH) extract, as well as their in vivo antioxidant activities in rats using the D-gal model. Results showed that the distribution of these polyphenol metabolites in plasma and organs may have positive effects on antioxidant enzymes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Mengwan Li, Xinhao Luo, Chi-Tang Ho, Daxiang Li, Huimin Guo, Zhongwen Xie
Summary: In this study, non-targeted metabolomics combined with chemometrics analysis was used to determine the four grades of Lu'an guapian green tea (LGGT) and identify eight grade-related biomarkers. Quantitative analysis further confirmed the grade-related metabolites. In vitro and in vivo data showed that higher grades of LGGT exhibited more potent hypoglycemic effects.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Se Rin Choi, Mee Youn Lee, Seung A. Kim, Jieun Oh, Da Won Hyun, Sarah Lee, Byoung-Hee Lee, Jae Youl Cho, Choong Hwan Lee
Summary: A new screening strategy using metabolomics was proposed to explore bioactive compounds in indigenous Korean plants. Phenolics showed positive correlation with antioxidant activity, while biflavonoids were correlated with nitric oxide inhibition activity. Validation results revealed significant differences in metabolites among different parts of Platycladus orientalis, yet biflavonoids contributed to both activities in the plant.
Article
Chemistry, Applied
Yongchang Lu, Xin Wang, Yong Wu, Zeyu Wang, Na Zhou, Jinjie Li, Xiaoya Shang, Pengcheng Lin
Summary: This study investigated the chemical composition and biological activity of Chinese Tibetan tea. It was found to have antioxidant and alpha-glucosidase inhibitory activities. Chromatographic separation and purification techniques were used to identify the most active fraction. UPLC-Orbitrap-MS/MS was employed to characterize the chemical composition, resulting in the annotation of 81 compounds, including 2 new compounds. The study provides a scientific basis for the development of antioxidant and anti-diabetic functional foods.
Article
Business
Reenu Kumari, Malik Shahzad Shabbir, Sharjeel Saleem, Ghulam Yahya Khan, Bilal Ahmed Abbasi, Lydia Bares Lopez
Summary: This study examines the long-term and causal relationship among foreign direct investment (FDI) inflows, trade openness and economic growth from India. The results confirm no long-term relationship among these three variables, but there is a bi-directional causality between economic growth and FDI. However, there is no bi-directional causality between trade openness and economic growth.
SOUTH ASIAN JOURNAL OF BUSINESS STUDIES
(2023)
Article
Environmental Sciences
Hummera Saleem, Muhammad Bilal Khan, Malik Shahzad Shabbir, Ghulam Yahya Khan, Muhammad Usman
Summary: This study investigates the dynamic relationships between non-renewable energy production, healthcare expenditures, and CO2 emissions in the OECD region. The results show that healthcare expenditures have a positive impact on energy production, and energy production has a positive unidirectional causal relationship with CO2 emissions. However, CO2 emissions have no significant relation with energy production. There is a positive bidirectional relationship between healthcare spending and CO2 emissions, but no evidence that healthcare spending causes energy production.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Environmental Sciences
Zhaomin Zhang, Tadadus Bashir, Jiaxuan Song, Shahab Aziz, Ghulam Yahya, Sana Bashir, Aysha Zamir
Summary: South Asia is a hub of air pollution, with 37 of the most polluted cities in the world located in this region. This study investigates the validity of the Environmental Kuznets Curve while considering the impacts of technological innovation and energy consumption, finding that the environment is deteriorating but technological innovations are helping to alleviate the impact. The empirical results show that energy consumption and technological innovations both have significant positive effects on CO2 emissions, which harm biodiversity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Zareen Arslan, Shazia Kausar, Desti Kannaiah, Malik Shahzad Shabbir, Ghulam Yahya Khan, Aysha Zamir
Summary: This study focuses on Pakistan's fertilizer industry, investigating the relationships among environmental consciousness, green creativity, green mindfulness, and energy efficiency. The results show that environmental consciousness positively affects employee energy efficiency directly and indirectly through green creativity as a mediator, with the moderating effect of green mindfulness. This empirical investigation provides insights for organizations to adopt effective policies for clean production and sustainable development.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Oncology
Wenbin Liu, Hongxiang Ji, Jun Zhao, Jiahui Song, Shaoling Zheng, Lei Chen, Peng Li, Xiaojie Tan, Yibo Ding, Rui Pu, Jianhua Yin, Xue Han, Guangwen Cao
Summary: APOBEC3-related mutations are associated with biliary tract cancers. The functional polymorphisms of APOBEC3A and APOBEC3B play important roles in the development of cholangiocarcinoma and gallbladder cancer. TNF-alpha regulates the levels of APOBEC3A and APOBEC3B by affecting transcriptional repressors and promoter accessibility.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Rui Pu, Wenbin Liu, Xinyu Zhou, Xi Chen, Xiaomei Hou, Shiliang Cai, Liping Chen, Jianfeng Wu, Fan Yang, Xiaojie Tan, Jianhua Yin, Xin Wang, Guangwen Cao
Summary: The study aimed to explore the mechanism by which hepatitis B virus X mutations increase the occurrence of hepatocellular carcinoma (HCC) and identify potential therapeutic targets. The results showed that M3-HBx and Ct-HBx mutants had a higher HCC incidence compared to wild-type HBx. M3-HBx had a stronger capacity to upregulate inflammatory cytokines and promote cell proliferation in HepG2 and HeLa cells. Plasminogen activator inhibitor-1 (PAI1) and cell division cycle 20 (CDC20) were identified as novel effectors, and their expression was significantly upregulated by M3-HBx and Ct-HBx in both cells and mouse livers. Silencing PAI1 attenuated the effects of M3-HBx and Ct-HBx on cell growth. PAI1 could be a promising prognostic biomarker and therapeutic target in HBV-related HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Environmental Sciences
Ruihua Wang, Qiaoyuan Fei, Shan Liu, Xueqiong Weng, Huanzhu Liang, Yingying Wu, Lin Wen, Guang Hao, Guangwen Cao, Chunxia Jing
Summary: This study assessed the effects of bisphenol F (BPF) and bisphenol S (BPS) as substitutes for bisphenol A (BPA) in the US population. The results suggest that BPS may increase the risk of cardiovascular disease (CVD) and coronary heart disease, especially in the 50-80 age group.
ENVIRONMENTAL SCIENCES EUROPE
(2022)
Article
Green & Sustainable Science & Technology
Misbah Sadiq, Desti Kannaiah, Ghulam Yahya Khan, Malik Shahzad Shabbir, Kanwal Bilal, Aysha Zamir
Summary: This study explores the environmental impacts of globalization in South Asia using the environment Kuznets curve approach. The findings show significant damage to environmental well-being in the region, while individual countries like Nepal demonstrate a positive and significant effect of non-environmentally friendly power and globalization index on CO2 emissions. Additionally, there is a feedback effect between economic growth and energy usage, with economic growth causing CO2 emissions.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Article
Green & Sustainable Science & Technology
Tabish Nawab, Saqlain Raza, Malik Shahzad Shabbir, Ghulam Yahya Khan, Sana Bashir
Summary: This study analyzes the measurement of MPI in Punjab and its components using the Alkire-Foster method. The findings show a decrease in MPI in Punjab from 2007 to 2018, with Southern Punjab experiencing higher poverty levels and industrialized districts having lower poverty levels. Health and education dimensions need improvement.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Article
Oncology
Jiansheng Lin, Hongwei Zhang, Hongping Yu, Xinyu Bi, Weilu Zhang, Jianhua Yin, Pei Zhao, Xiumei Liang, Chunfeng Qu, Minjie Wang, Ming Hu, Kun Liu, Yuting Wang, Zihan Zhou, Junqi Wang, Xiaojie Tan, Wenbin Liu, Zhongjun Shao, Jianqiang Cai, Weizhong Tang, Guangwen Cao
Summary: This study investigated the contribution of HBV and HCV to primary liver cancer and their association with cancer aggressiveness in China. The results showed that HBV accounted for 84.4% of HCC cases in China and was associated with clinical characteristics of the tumor. Early screening and preoperative prognosis prediction models are important in clinical decision-making.
FRONTIERS IN ONCOLOGY
(2022)
Article
Thermodynamics
Syed Muzamil Ahmed, S. N. Kazi, Ghullamullah Khan, Waqar Ahmed, M. N. M. Zubir
Summary: This study investigates the heat and momentum transfer properties of crop pulp fibre suspensions. The study finds that fibre concentration affects the heat transfer coefficient. By monitoring deviations in fibre properties, the degree of fibre refining treatment can be adjusted to ensure consistency in paper products.
HEAT AND MASS TRANSFER
(2023)
Article
Dermatology
Gang Chen, Mengwei Wang, Peiguang Wang, Bo Liang
Summary: We report a Chinese patient with Ichthyosis follicularis with atrichia and photophobia (IFAP) syndrome, presenting with the classic triad of follicular ichthyosis, alopecia, and photophobia, along with painful palmoplantar keratoderma, recurrent infections, periorificial keratotic plaques, nail dystrophy, and pachyonychia. Whole-exome sequencing identified an intronic variant (NM_015884.3: exon7:c.970+5G>A) in the MBTPS2 gene, which was confirmed to segregate with phenotype in the family. cDNA sequencing showed that the variant introduced a new splice donor site, leading to partial skipping of exon 7 (r.951_970del). An in vitro mini-gene assay demonstrated abnormal splicing of exon 7. This study highlights the importance of validation assays in determining the pathogenicity of intronic variants in MBTPS2.
JOURNAL OF DERMATOLOGY
(2023)
Review
Oncology
Zheyun Niu, Dongming Jiang, Jiaying Shen, Wenbin Liu, Xiaojie Tan, Guangwen Cao
Summary: Tumor development follows an evolutionary pattern of mutation-selection-adaptation, and FHIT plays a crucial role in this process by regulating gene expression and promoting retro-differentiation during cancer evolution and development. This article provides evidence on how FHIT is inactivated in cancer and highlights its importance in bridging macroevolution and microevolution.
Review
Biochemistry & Molecular Biology
Jiayi Zhao, Yiwei Shi, Guangwen Cao
Summary: The initiation and progression of tumors are complex, with the inflammation tumor microenvironment playing a crucial role. Single-cell RNA sequencing (scRNA-seq) can detect the transcription levels of cells, revealing the heterogeneity and evolutionary trajectory of infiltrated immune cells and cancer cells, providing insights into the composition and function of cells in the inflammatory tumor microenvironment.
Article
Food Science & Technology
Zeng Dong, Shirong Yu, Kefeng Zhai, Nina Bao, Marwan M. A. Rashed, Xiao Wu
Summary: This study aimed to explore the complex coacervation phenomenon between sesame protein isolate (SPI) and four different polysaccharides. Emulsions were fabricated and their rheological properties and microstructural characteristics were measured to assess their stability. Results showed the formation of complex between SPI and the polysaccharides at specific ratios and pH values. SPI-CMC and SPI-SA emulsions exhibited greater stability after storage.
