Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data
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Title
Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data
Authors
Keywords
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Journal
EYE
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-02-10
DOI
10.1038/s41433-020-01377-x
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Note: Only part of the references are listed.- Visual acuity outcomes and anti-VEGF therapy intensity in diabetic macular oedema: a real-world analysis of 28 658 patient eyes
- (2020) Thomas A Ciulla et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS
- (2020) Zhilin Li et al. JOURNAL OF CLINICAL INVESTIGATION
- Safety and Efficacy of Different Doses and Regimens of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration
- (2020) Jayashree Sahni et al. JAMA Ophthalmology
- Efficacy of Every Four Monthly and Quarterly Dosing of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration
- (2020) Arshad M. Khanani et al. JAMA Ophthalmology
- Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration
- (2019) Jaeryung Kim et al. Science Advances
- Simultaneous Inhibition of Angiopoietin-2 and VEGF-A with Faricimab in Diabetic Macular Edema: BOULEVARD Phase 2 Randomized Trial
- (2019) Jayashree Sahni et al. OPHTHALMOLOGY
- Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases
- (2019) Jörg T Regula et al. EMBO Molecular Medicine
- Efficacy of simultaneous VEGF‐A/ANG‐2 neutralization in suppressing spontaneous choroidal neovascularization
- (2019) Richard H Foxton et al. EMBO Molecular Medicine
- HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration
- (2019) Pravin U. Dugel et al. OPHTHALMOLOGY
- Macrophage Plasticity and Function in the Eye and Heart
- (2019) Zelun Wang et al. TRENDS IN IMMUNOLOGY
- Comprehensive expression patterns of inflammatory cytokines in aqueous humor of patients with neovascular age-related macular degeneration
- (2019) Tomohito Sato et al. Scientific Reports
- Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer
- (2018) Carmine Carbone et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Role of Inflammation in Diabetic Retinopathy
- (2018) Anne Rübsam et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Resolution of organ fibrosis
- (2018) Joon-Il Jun et al. JOURNAL OF CLINICAL INVESTIGATION
- Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP
- (2018) Tomokazu Souma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PROGRESSION OF MACULAR ATROPHY IN EYES WITH TYPE 1 NEOVASCULARIZATION AND AGE-RELATED MACULAR DEGENERATION RECEIVING LONG-TERM INTRAVITREAL ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY
- (2018) Joseph G. Christenbury et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- BTBR ob/ob mouse model of type 2 diabetes exhibits early loss of retinal function and retinal inflammation followed by late vascular changes
- (2018) Vivian K. Lee et al. DIABETOLOGIA
- Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction
- (2018) Seung-Jun Lee et al. JOURNAL OF CLINICAL INVESTIGATION
- Therapeutic targeting of the angiopoietin–TIE pathway
- (2017) Pipsa Saharinen et al. NATURE REVIEWS DRUG DISCOVERY
- Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
- (2017) Martin Teichert et al. Nature Communications
- Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases
- (2016) Jörg T Regula et al. EMBO Molecular Medicine
- Subretinal AAV2.COMP-Ang1 suppresses choroidal neovascularization and vascular endothelial growth factor in a murine model of age-related macular degeneration
- (2016) Nathan G. Lambert et al. EXPERIMENTAL EYE RESEARCH
- Molecular mechanisms of subretinal fibrosis in age-related macular degeneration
- (2016) Keijiro Ishikawa et al. EXPERIMENTAL EYE RESEARCH
- The corneal fibrosis response to epithelial–stromal injury
- (2016) Andre A.M. Torricelli et al. EXPERIMENTAL EYE RESEARCH
- Risk of geographic atrophy in age-related macular degeneration patients treated with intravitreal anti-VEGF agents
- (2016) M Gemenetzi et al. EYE
- Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation
- (2016) Minah Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Tie1 controls angiopoietin function in vascular remodeling and inflammation
- (2016) Emilia A. Korhonen et al. JOURNAL OF CLINICAL INVESTIGATION
- Ten years of anti-vascular endothelial growth factor therapy
- (2016) Napoleone Ferrara et al. NATURE REVIEWS DRUG DISCOVERY
- Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema
- (2016) John A. Wells et al. OPHTHALMOLOGY
- Five-Year Outcomes with Anti–Vascular Endothelial Growth Factor Treatment of Neovascular Age-Related Macular Degeneration
- (2016) Maureen G. Maguire et al. OPHTHALMOLOGY
- Angiopoietin 2 induces astrocyte apoptosis via αvβ5-integrin signaling in diabetic retinopathy
- (2016) J-H Yun et al. Cell Death & Disease
- Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma
- (2016) Chunhua Yang et al. Drug Design Development and Therapy
- Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration
- (2016) Toshihide Kurihara et al. eLife
- Histopathological Insights Into Choroidal Vascular Loss in Clinically Documented Cases of Age-Related Macular Degeneration
- (2016) Johanna M. Seddon et al. JAMA Ophthalmology
- Mechanisms of Vessel Pruning and Regression
- (2015) Claudia Korn et al. DEVELOPMENTAL CELL
- Molecular pathogenesis of retinal and choroidal vascular diseases
- (2015) Peter A. Campochiaro PROGRESS IN RETINAL AND EYE RESEARCH
- Endothelial destabilization by angiopoietin-2 via integrin β1 activation
- (2015) Laura Hakanpaa et al. Nature Communications
- The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells
- (2015) Soniya Savant et al. Cell Reports
- A Mouse Model for Laser-induced Choroidal Neovascularization
- (2015) Ronil S. Shah et al. Jove-Journal of Visualized Experiments
- Postsurgical Adjuvant Tumor Therapy by Combining Anti-Angiopoietin-2 and Metronomic Chemotherapy Limits Metastatic Growth
- (2014) Kshitij Srivastava et al. CANCER CELL
- Angiopoietin 2 Induces Pericyte Apoptosis via 3 1 Integrin Signaling in Diabetic Retinopathy
- (2014) S. W. Park et al. DIABETES
- Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature
- (2014) Jikui Shen et al. JOURNAL OF CLINICAL INVESTIGATION
- Overview of the cellular and molecular basis of kidney fibrosis
- (2014) Allison A. Eddy Kidney International Supplements
- Ang-2-VEGF-A CrossMab, a Novel Bispecific Human IgG1 Antibody Blocking VEGF-A and Ang-2 Functions Simultaneously, Mediates Potent Antitumor, Antiangiogenic, and Antimetastatic Efficacy
- (2013) Y. Kienast et al. CLINICAL CANCER RESEARCH
- Angiopoietin-2 Is Critical for Cytokine-Induced Vascular Leakage
- (2013) Andrew V. Benest et al. PLoS One
- Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling
- (2012) Moritz Felcht et al. JOURNAL OF CLINICAL INVESTIGATION
- Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration
- (2012) Daniel F. Martin et al. OPHTHALMOLOGY
- Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease
- (2012) Joanna Kur et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Angiopoietin-1 Requires IQ Domain GTPase-Activating Protein 1 to Activate Rac1 and Promote Endothelial Barrier Defense
- (2011) Sascha David et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Angiopoietin-2 promotes myeloid cell infiltration in a 2-integrin-dependent manner
- (2011) A. Scholz et al. BLOOD
- Basic and Therapeutic Aspects of Angiogenesis
- (2011) Michael Potente et al. CELL
- Angiopoietin-1 is essential in mouse vasculature during development and in response to injury
- (2011) Marie Jeansson et al. JOURNAL OF CLINICAL INVESTIGATION
- Molecular mechanisms and clinical applications of angiogenesis
- (2011) Peter Carmeliet et al. NATURE
- Molecular control of endothelial cell behaviour during blood vessel morphogenesis
- (2011) Shane P. Herbert et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1
- (2010) Harprit Singh et al. MICROVASCULAR RESEARCH
- Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
- (2010) Lars Jakobsson et al. NATURE CELL BIOLOGY
- Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema
- (2010) Michael J. Elman et al. OPHTHALMOLOGY
- Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
- (2009) Hellmut G. Augustin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Introduction: Understanding the Role of Angiogenesis and Antiangiogenic Agents in Age-Related Macular Degeneration
- (2009) Susan B. Bressler OPHTHALMOLOGY
- Pericyte Migration: A Novel Mechanism of Pericyte Loss in Experimental Diabetic Retinopathy
- (2008) F. Pfister et al. DIABETES
- Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1
- (2008) Shigetomo Fukuhara et al. NATURE CELL BIOLOGY
- Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts
- (2008) Pipsa Saharinen et al. NATURE CELL BIOLOGY
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