Article
Immunology
Tomohito Sato, Toshio Enoki, Yoko Karasawa, Hideaki Someya, Manzo Taguchi, Kozo Harimoto, Kei Takayama, Takayuki Kanda, Masataka Ito, Masaru Takeuchi
Summary: In patients with neovascular age-related macular degeneration, changes in predictive cytokines can be used as biomarkers for predicting the occurrence of macula atrophy, with substantial loss of interferon-?-inducible protein 10 (IP-10) effects and persistent inflammation playing an important role in the incidence of macula atrophy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Ophthalmology
Batya Rinsky, Gala Beykin, Michelle Grunin, Radgonde Amer, Samer Khateb, Liran Tiosano, Diego Almeida, Shira Hagbi-Levi, Sarah Elbaz-Hayoun, Itay Chowers
Summary: The study analyzed the aqueous humor proteome of AMD patients, identifying several proteins and functional clusters with altered expression. Clusterin and Serpin A4 showed potential as biomarkers, with further research needed to confirm their role in the disease.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Ophthalmology
Samuel A. Minaker, Ryan H. Mason, Gabriela Lahaie Luna, Priya Bapat, Rajeev H. Muni
Summary: Inflammatory cytokines play a crucial role in the development of neovascular age-related macular degeneration (nAMD) and can serve as valuable diagnostic and predictive biomarkers. Through a systematic review of 95 studies, it was found that MCP-1, MIG, TGF-beta, and VEGF concentrations in the aqueous humor were significantly higher in nAMD patients compared to healthy controls. The analysis also identified multiple candidate cytokines besides VEGF associated with nAMD, providing clarity to previous literature and guiding future research on biomarkers and therapeutic targets in nAMD.
ACTA OPHTHALMOLOGICA
(2021)
Article
Medicine, General & Internal
Ching-Yao Tsai, Chueh-Tan Chen, Hsin-Han Wu, Chen-Chung Liao, Kate Hua, Chung-Hua Hsu, Chian-Feng Chen
Summary: This study examined the exosomal protein profile of patients with age-related macular degeneration (AMD) and found significant differences in the exosomal proteins between AMD patients and controls. The exosomal proteins in AMD patients were enriched in the lipoprotein metabolic process. Additionally, the study observed a decrease in the amount of two proteins in AMD patients receiving anti-VEGF therapy with longer treatment duration.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Jianbo Mao, Nuo Chen, Shian Zhang, Yuyan Fang, Zicheng Zheng, Sulan Wu, Xin Ye, Yijing Chen, Yiqi Chen, Lijun Shen
Summary: This study investigates the associations between cytokine levels in aqueous humor (AH) and hyperreflective foci (HF) on spectral-domain optical coherence tomography (SD-OCT) in neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV). The results suggest that in the nAMD group, HF is positively correlated with VEGF, and patients with HF have elevated levels of VEGF and IL-10 and respond favorably to anti-VEGF treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Yusuke Ichiyama, Tomoko Sawada, Osamu Sawada, Yuka Ito, Masashi Kakinoki, Shumpei Obata, Yoshitsugu Saishin, Masahito Ohji
Summary: The study aimed to investigate the correlation between pretreatment aqueous VEGF levels and recurrence risk in neovascular age-related macular degeneration. Results showed a significant association between higher VEGF levels and recurrence, suggesting that measuring pretreatment VEGF levels may aid in determining optimal treatment options for patients with this condition.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Steffen E. Kuenzel, Leonie T. M. Flesch, Dominik P. Frentzel, Vitus A. Knecht, Anne Ruebsam, Felix Dreher, Moritz Schuette, Alexandre Dubrac, Bodo Lange, Marie-Laure Yaspo, Hans Lehrach, Antonia M. Joussen, Oliver Zeitz
Summary: The BIOMAC study investigates the link between systemic proteomic signals and macular disease in neovascular age-related macular degeneration (nAMD) under anti-VEGF therapy. By analyzing proteomic profiles and clinical features, the study identifies underlying health conditions, biomarkers for disease control, and complex molecular patterns determining disease expression. These findings highlight the importance of considering systemic signals in understanding and treating nAMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Assaf Hilely, Adrian Au, K. Bailey Freund, Anat Loewenstein, Eric H. Souied, Dinah Zur, Riccardo Sacconi, Enrico Borrelli, Enrico Peiretti, Claudio Iovino, Yoshimi Sugiura, Abdallah A. Ellabban, Jordi Mones, Nadia K. Waheed, Sengul Ozdek, Duygu Yalinbas, Sarah Thiele, Luisa Salles de Moura Mendonca, Mee Yon Lee, Won Ki Lee, Pierre Turcotte, Vittorio Capuano, Meryem Filali Ansary, Usha Chakravarthy, Albrecht Lommatzsch, Frederic Gunnemann, Daniel Pauleikhoff, Michael S. Ip, Giuseppe Querques, Frank G. Holz, Richard F. Spaide, SriniVas Sadda, David Sarraf
Summary: This study evaluated the patterns of subretinal fluid in eyes with non-neovascular AMD and found that SRF may be a result of RPE decompensation and RPE pump failure.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Chemistry, Medicinal
Tingting Sun, Qingquan Wei, Peng Gao, Yongjie Zhang, Qing Peng
Summary: The study investigated cytokine and chemokines profiling in the aqueous humor of nAMD patients, finding lower levels of basic fibroblast growth factor and RANTES, and higher levels of VEGF-A compared to the control group. After IVR treatment, levels of Eotaxin increased while VEGF-A decreased in nAMD patients.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Ophthalmology
Joo Youn Shin, Jonghyun Lee, Jinkyu Park, Min Kim, Hyewon Chung, Suk Ho Byeon
Summary: This study investigated the level of keratin 8 (KRT8) in the aqueous humor of patients with neovascular age-related macular degeneration (nAMD) and its association with intravitreal ranibizumab (IVR) treatment outcomes. It was found that monitoring the KRT8 level in the aqueous humor can facilitate early determination of the therapeutic effects of IVR and reflect the condition of the retinal pigment epithelium.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Ophthalmology
Huiying Zhou, Xinyu Zhao, Youxin Chen
Summary: The study found significant differences in plasma concentrations of multiple cytokines between nAMD and PCV patients and controls, suggesting potential involvement in the pathogenesis of the diseases. The measurement of leukemia inhibitory factor in plasma may serve as a differentiating factor between nAMD and PCV.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Pharmacology & Pharmacy
Joanna Dolar-Szczasny, Claudio Bucolo, Sandrine Zweifel, Adriano Carnevali, Robert Rejdak, Wojciech Zaluska, Aleksandra Czarnek-Chudzik, Mario Damiano Toro
Summary: The study evaluated the effect of repeated intravitreal bevacizumab injections on blood-aqueous barrier permeability in eyes with neovascular AMD. The results showed that monthly bevacizumab dosing seems to be safe and does not induce anterior chamber inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Hanna Helotera, Kai Kaarniranta
Summary: Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. It is classified into dry and neovascular forms, with neovascular AMD being associated with angiogenesis and inflammatory regulators.
Article
Ophthalmology
Clement K. Chan, Wesley T. Beaulieu, Brandon J. Lujan, Maziar Lalezary, Daniella Lent-Schochet, Therlinder Lo, Glenn Yiu
Summary: The purpose of this study was to investigate the impact of prophylactic ranibizumab injections on drusen volume, macular thinning, and GA progression in eyes with intermediate AMD. The results showed that prophylactic ranibizumab did not appear to affect these parameters. Additionally, there was no difference in the conversion rate to neovascular AMD between the PR and sham injection groups.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Cell Biology
Sabrina L. Mitchell, Chunyu Ma, William K. Scott, Anita Agarwal, Margaret A. Pericak-Vance, Jonathan L. Haines, Dean P. Jones, Karan Uppal, Milam A. Brantley Jr
Summary: High resolution untargeted metabolomics was used to study plasma metabolite alterations in intermediate and neovascular age-related macular degeneration (IAMD and NVAMD). Numerous discriminatory metabolic features were identified, including acylcarnitines, phospholipids, amino acids, and steroid metabolites. Pathway analysis revealed lipid, amino acid, and vitamin metabolism pathways were altered in AMD, with the carnitine shuttle pathway significantly affected in all comparisons. Fewer differences were found between IAMD patients and controls, indicating that plasma metabolic profiles of IAMD patients are more similar to controls than to NVAMD patients.