Novel ligands and modulators of triggering receptor expressed on myeloid cells receptor family: 2015-2020 updates

Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer’s disease models

(2021) Michael Fassler et al.   Journal of Neuroinflammation

Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease

(2021) Daniel C. Ellwanger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus

(2020) Jiawei Zhang et al.   Journal of Neuroinflammation

Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region

(2020) Kai Schlepckow et al.   EMBO Molecular Medicine

Triggering receptor expressed on myeloid cells-1 (TREM-1) as a therapeutic target in infectious and noninfectious disease: a critical review

(2020) Pedro Henrique dos Santos Dantas et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Construction of a human cell landscape at single-cell level

(2020) Xiaoping Han et al.   NATURE

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

(2020) Shoutang Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Triggering Receptor Expressed On Myeloid Cells-2 Protects Aged Mice Against Sepsis By Mitigating The Il-23/Il-17A Response

(2020) QiXing Chen et al.   SHOCK

Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion

(2020) Bianca Cioni et al.   Nature Communications

Extracellular CIRP (eCIRP) and inflammation

(2019) Monowar Aziz et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Blocking TREM-1+ Tumor-associated macrophages induced by hypoxia reverses immunosuppression and anti-PD-L1 resistance in liver cancer

(2019) Qinchuan Wu et al.   HEPATOLOGY

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells

(2019) Jinhee Hyun et al.   PLoS Pathogens

Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy

(2018) Modesto A. Rojas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer’s Disease

(2018) Iryna Voytyuk et al.   BIOLOGICAL PSYCHIATRY

CIRP increases ICAM-1+ phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis

(2018) Yasumasa Ode et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

(2018) Li Zhong et al.   Molecular Neurodegeneration

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

(2018) Samira Parhizkar et al.   NATURE NEUROSCIENCE

Rationally designed ligand-independent peptide inhibitors of TREM-1 ameliorate collagen-induced arthritis

(2017) Zu T. Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TREM2-Ligand Interactions in Health and Disease

(2017) Daniel L. Kober et al.   JOURNAL OF MOLECULAR BIOLOGY

Novel TREM-1 Inhibitors Attenuate Tumor Growth and Prolong Survival in Experimental Pancreatic Cancer

(2017) Zu T. Shen et al.   MOLECULAR PHARMACEUTICS

TREM-1 promotes intestinal tumorigenesis

(2017) Leslie Saurer et al.   Scientific Reports

Increased TREM-2 expression on the subsets of CD11c+ cells in the lungs and lymph nodes during allergic airway inflammation

(2017) Sannette C. Hall et al.   Scientific Reports

Identification of Extracellular Actin As a Ligand for Triggering Receptor Expressed on Myeloid Cells-1 Signaling

(2017) Lei Fu et al.   Frontiers in Immunology

Tumor necrosis factor-α regulates triggering receptor expressed on myeloid cells-1-dependent matrix metalloproteinases in the carotid plaques of symptomatic patients with carotid stenosis

(2016) Velidi H. Rao et al.   ATHEROSCLEROSIS

Trem-1 is not crucial in psoriasiform imiquimod-induced skin inflammation in mice

(2016) Jérémie Joffre et al.   EXPERIMENTAL DERMATOLOGY

Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis

(2016) Jeremie Joffre et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis

(2016) Daniel Zysset et al.   Nature Communications

Cold-inducible RNA-binding protein causes endothelial dysfunction via activation of Nlrp3 inflammasome

(2016) Weng-Lang Yang et al.   Scientific Reports

Effect of TREM-1 blockade and single nucleotide variants in experimental renal injury and kidney transplantation

(2016) A. Tammaro et al.   Scientific Reports

High Expression Levels of Trigger Receptor Expressed on Myeloid Cells-1 on Neutrophils Associated with Increased Severity of Acute Pancreatitis in Mice

(2015) Mulin Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction

(2015) A. Boufenzer et al.   CIRCULATION RESEARCH

Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1

(2015) Christine B. Read et al.   JOURNAL OF IMMUNOLOGY

Monosodium urate crystal-induced triggering receptor expressed on myeloid cells 1 is associated with acute gouty inflammation

(2015) Jennifer Lee et al.   RHEUMATOLOGY

Kinetics of gene expression and bone remodelling in the clinical phase of collagen-induced arthritis

(2015) Katja CM Denninger et al.   ARTHRITIS RESEARCH & THERAPY

Triggering receptor expressed on myeloid cells receptor family modulators: a patent review

(2014) Christopher J Pelham et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopolysaccharide-induced septic shock

(2014) Alexander B. Sigalov   INTERNATIONAL IMMUNOPHARMACOLOGY

Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide

(2014) K. Dower et al.   JOURNAL OF IMMUNOLOGY

TREM-1 regulates macrophage polarization in ureteral obstruction

(2014) Tzu-Han Lo et al.   KIDNEY INTERNATIONAL

TREM-1 Deficiency Can Attenuate Disease Severity without Affecting Pathogen Clearance

(2014) Benjamin Weber et al.   PLoS Pathogens

Attenuation of Responses to Endotoxin by the Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor LR12 in Nonhuman Primate

(2013) Marc Derive et al.   ANESTHESIOLOGY

Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis

(2013) Xiaoling Qiang et al.   NATURE MEDICINE

Modulation of Cytokine Release and Gene Expression by the Immunosuppressive Domain of gp41 of HIV-1

(2013) Joachim Denner et al.   PLoS One

Genetic Association of Peptidoglycan Recognition Protein Variants with Inflammatory Bowel Disease

(2013) Fareeha Zulfiqar et al.   PLoS One

Effects of a TREM-Like Transcript 1–Derived Peptide During Hypodynamic Septic Shock in Pigs

(2013) Marc Derive et al.   SHOCK

The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma

(2012) Juan Wu et al.   CANCER RESEARCH

Soluble Trem-like Transcript-1 Regulates Leukocyte Activation and Controls Microbial Sepsis

(2012) M. Derive et al.   JOURNAL OF IMMUNOLOGY

TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors

(2012) R. J. W. Arts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gene Expression Changes Induced by Unilateral Ureteral Obstruction in Mice

(2012) Bo Wu et al.   JOURNAL OF UROLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1

(2012) Vladimir A Morozov et al.   Retrovirology

Triggering Receptor Expressed on Myeloid Cell 1

(2011) Damien Barraud et al.   CRITICAL CARE CLINICS

Induction of triggering receptor expressed on myeloid cells (TREM-1) in airway epithelial cells by 1,25(OH)2 vitamin D3

(2011) Isaura Rigo et al.   Innate Immunity

Triggering receptor expressed on myeloid cells (TREM)-1 participates in Schistosoma mansoni inflammatory responses

(2011) P.-C. CHENG et al.   PARASITE IMMUNOLOGY

Peptidoglycan Recognition Proteins Protect Mice from Experimental Colitis by Promoting Normal Gut Flora and Preventing Induction of Interferon-γ

(2010) Sukumar Saha et al.   Cell Host & Microbe

New B-cell CD molecules

(2010) Jessica Matesanz-Isabel et al.   IMMUNOLOGY LETTERS

Cathelicidin Peptide LL-37 Modulates TREM-1 Expression and Inflammatory Responses to Microbial Compounds

(2010) Gimano D. Amatngalim et al.   INFLAMMATION

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis

(2009) Yousuke Murakami et al.   ARTHRITIS AND RHEUMATISM

Effects of the TREM-1 pathway modulation during mesenteric ischemia-reperfusion in rats

(2009) Sébastien Gibot et al.   CRITICAL CARE MEDICINE

TREM and TREM-like receptors in inflammation and disease

(2009) Jill W Ford et al.   CURRENT OPINION IN IMMUNOLOGY

EFFECTS OF THE TREM 1 PATHWAY MODULATION DURING HEMORRHAGIC SHOCK IN RATS

(2009) Sébastien Gibot et al.   SHOCK

From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection

(2008) Omar Sharif et al.   IMMUNOBIOLOGY

The TREM-1/DAP12 pathway

(2008) Anja S. Tessarz et al.   IMMUNOLOGY LETTERS

Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia

(2007) Li C. Chen et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY