Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases

Neuronutrition and Alzheimer's Disease

(2017) Balenahalli N. Ramesh et al.   JOURNAL OF ALZHEIMERS DISEASE

The Characterization of the Caenorhabditis elegans Mitochondrial Thioredoxin System Uncovers an Unexpected Protective Role of Thioredoxin Reductase 2 in β-Amyloid Peptide Toxicity

(2012) Briseida Cacho-Valadez et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans

(2012) Annette O. Estevez et al.   NEUROTOXICOLOGY

Using Multiple Phenotype Assays and Epistasis Testing to Enhance the Reliability of RNAi Screening and Identify Regulators of Muscle Protein Degradation

(2012) Susann Lehmann et al.   Genes

Amyloid deposits: Protection against toxic protein species?

(2011) Sebastian Treusch et al.   CELL CYCLE

Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases

(2011) P. H. Reddy et al.   Current Alzheimer Research

Structural Basis of an ERAD Pathway Mediated by the ER-Resident Protein Disulfide Reductase ERdj5

(2011) Masatoshi Hagiwara et al.   MOLECULAR CELL

A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo

(2011) Virginia Fonte et al.   Molecular Neurodegeneration

Identification and Functional Clustering of Genes Regulating Muscle Protein Degradation from amongst the Known C. elegans Muscle Mutants

(2011) Freya Shephard et al.   PLoS One

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

(2011) M. Catarina Silva et al.   PLoS Genetics

Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity

(2010) Tjakko J. van Ham et al.   CELL

C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms

(2010) Ye Tian et al.   CELL

Caenorhabditis elegansas a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases

(2010) Janine Kirstein-Miles et al.   DEVELOPMENTAL DYNAMICS

Cellular mechanisms of posterior neural tube morphogenesis in the zebrafish

(2010) Michael J. Harrington et al.   DEVELOPMENTAL DYNAMICS

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-  Generation

(2010) M. Kaneko et al.   JOURNAL OF NEUROSCIENCE

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

Caenorhabditis elegans diet significantly affects metabolic profile, mitochondrial DNA levels, lifespan and brood size

(2010) S.N. Reinke et al.   MOLECULAR GENETICS AND METABOLISM

Chaperone networks: Tipping the balance in protein folding diseases

(2010) Cindy Voisine et al.   NEUROBIOLOGY OF DISEASE

A Neuromedin U Receptor Acts with the Sensory System to Modulate Food Type-Dependent Effects on C. elegans Lifespan

(2010) Wolfgang Maier et al.   PLOS BIOLOGY

Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection

(2009) Ehud Cohen et al.   AGING CELL

Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland

(2009) Akira Hosoda et al.   BIOCHEMICAL JOURNAL

Abnormal mitochondrial dynamics and neurodegenerative diseases

(2009) Bo Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Derlin-dependent accumulation of integral membrane proteins at cell surfaces

(2009) B. Schaheen et al.   JOURNAL OF CELL SCIENCE

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

(2008) M. L. Duennwald et al.   GENES & DEVELOPMENT

Effects of overexpression of Huntingtin proteins on mitochondrial integrity

(2008) Hongmin Wang et al.   HUMAN MOLECULAR GENETICS

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

(2008) S. Hamamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER

(2008) R. Ushioda et al.   SCIENCE

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics