Article
Pharmacology & Pharmacy
Qing Hu, Xiaoling Fu, Yanping Su, Yanfang Wang, Sihuan Gao, Xiaoqin Wang, Ying Xu, Changxi Yu
Summary: This study successfully improved the bioavailability of Koumine (KME) by optimizing the synthesis of inclusion complexes, resulting in enhanced solubility and intestinal absorption efficiency.
Article
Chemistry, Physical
Larissa dos Santos Silva Araujo, Giuseppe Lazzara, Leonardo Chiappisi
Summary: This study provides a comprehensive overview of the thermodynamics aspects of surfactants and CDs inclusion complexes formation in aqueous environment, emphasizing the assessment of interactions, thermodynamic driving forces, and structural aspects. It also discusses the most common analytical techniques used to gather deep insight into CDs complexes, pointing out the perspectives for the surfactant-cyclodextrin complexes.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Lucia Casali, Valquiria Broll, Stefano Ciurli, Franziska Emmerling, Dario Braga, Fabrizia Grepioni
Summary: The inclusion complex beta-CD center dot NP, prepared via mechanochemical synthesis, shows improved solubility and thermal stability, while still effectively inhibiting the enzymatic activity of AMO. This indicates that the inclusion of NP into beta-CD is a promising approach for creating novel inhibitors with enhanced properties.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Oncology
Yun Wang, Qian Liang, Kefeng Lei, Qingqing Zhu, Delong Zeng, Yuhong Liu, Yingsi Lu, Tingting Kang, Nannan Tang, Lifen Huang, Liping Ye, Di Tang, Chengming Zhu
Summary: MEX3A expression is significantly upregulated in breast cancer, related to tumor grade, and plays a critical role in promoting metastasis and maintaining stemness through the Wnt/beta-catenin pathway.
Article
Chemistry, Multidisciplinary
Qianming Lin, Longyu Li, Miao Tang, Shuntaro Uenuma, Jayanta Samanta, Shangda Li, Xuanfeng Jiang, Lingyi Zou, Kohzo Ito, Chenfeng Ke
Summary: The study demonstrates a method for controlling molecular assembly structures through kinetic trapping design and amplifying them to the macroscale, achieving the capturing of transient polypseudorotaxanes from solution and obtaining materials with different physical properties. By 3D printing different shapes of polypseudorotaxane networks, moisture-responsive actuators can be constructed.
Review
Food Science & Technology
Jiaojiao Zhou, Jilai Jia, Jiangling He, Jinjie Li, Jie Cai
Summary: Food safety issues pose a significant threat to public health and require accurate, efficient, sensitive, and economical detection methods. Cyclodextrins (CDs), with their non-toxic and non-caloric properties, have shown promise in enhancing stability and selectively capturing target molecules for improved food detection sensitivity.
Article
Chemistry, Physical
Ping Han, Yuanyuan Zhong, Ning An, Shiling Lu, Qingling Wang, Juan Dong
Summary: Sesamol, a natural organic phenolic compound, has great potential in food and chemical industries but faces challenges with instability and poor aqueous solubility. In this study, three inclusion complexes were prepared using cyclodextrins as host molecules to enhance sesamol's water-solubility, with HP-beta-CD identified as the optimal host molecule.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Irina Giralt, Gabriel Gallo-Oller, Natalia Navarro, Patricia Zarzosa, Guillem Pons, Ainara Magdaleno, Miguel F. Segura, Constantino Sabado, Raquel Hladun, Diego Arango, Jose Sanchez de Toledo, Lucas Moreno, Soledad Gallego, Josep Roma
Summary: The study demonstrates the therapeutic potential of DKK-1 pharmaceutical inhibition in rhabdomyosarcoma, resulting in beta-catenin activation and modulation of focal adhesion kinase, with positive effects on myogenic marker expression and a reduction in proliferation and invasion. In addition, the chemical inhibitor WAY-262611 was able to impair tumor cell survival in vivo, suggesting DKK-1 as a potential molecular target for novel therapeutic strategies in RMS patients, especially those with high DKK-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Fang Shen, Celiang Wu, Xiaomei Zhong, En Ma, Jun Peng, Weidong Zhu, Da Wo, Dan-ni Ren
Summary: The study aims to evaluate the cardioprotective effects of Liensinine (LSN) following myocardial infarction (MI) and its underlying mechanisms. Results showed that LSN administration effectively reduced ischemic damage and improved cardiac function. It was also found that LSN inhibits the Wnt/beta-catenin signaling pathway, leading to prevention of oxidative stress and DNA damage. These findings suggest a novel therapeutic potential of LSN or plants containing LSN in ischemic heart diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Physical
Ting Gu, Jianbin Huang, Yun Yan
Summary: We report that gamma-cyclodextrin (gamma-CD) catalyzes the self-assembly of pyrenebutyrate with Zn2+. The addition of Zn2+ to the host-guest complex of pyrenebutyrate and gamma-CD generates well-defined microflowers with the same composition as the amorphous pyrenebutyrate/Zn2+. This suggests that gamma-CD acts as a catalyst in the self-assembly process.
Article
Chemistry, Multidisciplinary
Ladislav Sivak, Vladimir Subr, Jirina Kovarova, Barbora Dvorakova, Milada Sirova, Blanka Sihova, Eva Randarova, Michal Kraus, Jakub Tomala, Martin Studenovsky, Michaela Vondrackova, Radislav Sedlacek, Petr Makovicky, Jitka Fucikova, Sarka Vosahlikova, Radek Spisek, Libor Kostka, Tomas Etrych, Marek Kovar
Summary: Repurposing drug strategy using P-RD nanomedicine has successfully identified the anticancer effects of RD on cancer cells, which has been validated in mice experiments and human cancer cell lines, making it a promising therapeutic candidate with great potential for deep preclinical investigation.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Larissa dos Santos Silva Araujo, Leah Watson, Daouda A. K. Traore, Giuseppe Lazzara, Leonardo Chiappisi
Summary: The inclusion complexes of alkyl ethoxy carboxylates with α-cyclodextrin and β-cyclodextrin were studied. The complexation process was found to be enthalpically driven and independent of pH. The complexes self-assembled into highly-ordered supramolecular aggregates, with different morphologies influenced by the number of ethylene oxides in the surfactants and the cyclodextrin cavity size.
Article
Cell Biology
Andre Landin Malt, Shaylyn Clancy, Diane Hwang, Alice Liu, Connor Smith, Margaret Smith, Maya Hatley, Christopher Clemens, Xiaowei Lu
Summary: A non-canonical Wnt signaling pathway has been found to promote cochlear outgrowth and coordinate planar polarization of hair cells. Gsk3 beta and Rac1 play crucial roles in this pathway, as shown in genetic rescue experiments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lu Han, Feng Li
Summary: The study demonstrates that ORC1 is upregulated in lung adenocarcinoma (LUAD) and correlates with poor prognosis. ORC1 is negatively associated with immune infiltrating cells and involved in various molecular functions. In vitro and in vivo experiments show that ORC1 promotes malignant behaviors and tumor growth of LUAD cells. Mechanistically, ORC1 regulates the Wnt signaling pathway in LUAD cells. Therefore, ORC1 could serve as a promising biomarker or therapeutic target for LUAD.
Article
Pharmacology & Pharmacy
Abbas Ismail, Khanittha Kerdpol, Thanyada Rungrotmongkol, Kanitha Tananuwong, Takafumi Ueno, Sanong Ekasit, Nongnuj Muangsin, Kuakarun Krusong
Summary: Complexation of domperidone with large ring cyclodextrins can significantly improve its water solubility, with the LR-CD/DMP complex showing the most significant enhancement. The molecular dynamic results indicate that stable complexes are formed between DMP and CD33, leading to a 2.7-fold increase in DMP solubility.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Kamila Butowska, Xuexiang Han, Ningqiang Gong, Rakan El-Mayta, Rebecca M. Haley, Lulu Xue, Wenqun Zhong, Wei Guo, Karin Wang, Michael J. Mitchell
Summary: Evasion of apoptosis is a characteristic of cancer, and overexpression of Bcl-2 is a contributing factor. Therapeutic targeting of Bcl-2 has shown efficacy in the clinic and is being extensively tested in combination with chemotherapy. Therefore, developing co-delivery systems for Bcl-2 targeting agents and chemotherapeutics, such as LNPs, holds promise for combination cancer therapies.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Biochemical Research Methods
Ghazal Bashiri, Marshall S. Padilla, Kelsey L. Swingle, Sarah J. Shepherd, Michael J. Mitchell, Karin Wang
Summary: Nanoparticle (NP)-based therapeutics have revolutionized translational medicine, but the mechanisms by which NPs interact and evolve in biological environments remain poorly understood. When exposed to physiological fluids, NPs are encased in a protein corona (PC) that can profoundly impact their behavior. The conformation and orientation of proteins in vivo can be influenced by biological factors and interactions with NPs, potentially altering their function. This review explores the effects of PC on protein conformation and discusses how this knowledge can be leveraged for therapeutic purposes.
Article
Multidisciplinary Sciences
Xuexiang Han, Ningqiang Gong, Lulu Xue, Margaret M. Billingsley, Rakan El-Mayta, Sarah J. Shepherd, Mohamad-Gabriel Alameh, Drew Weissman, Michael J. Mitchell
Summary: By synthesizing AA-lipidoids with high delivery efficiency and selectivity, and validating in a preclinical model of liver fibrosis, the potential of AA-lipidoids for targeted RNA delivery to activated fibroblasts has been demonstrated.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Chemistry, Physical
Ningqiang Gong, Alex G. G. Hamilton, Michael J. J. Mitchell
Summary: A curvature-sensing peptide is utilized to disrupt exosomes, leading to improved cancer immunotherapy.
Editorial Material
Nanoscience & Nanotechnology
Ningqiang Gong, Michael. J. J. Mitchell
Summary: Drug delivery to the bone marrow is not efficient enough. Hitchhiking on bone marrow homing neutrophils provides a solution.
NATURE NANOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Pedro P. G. Guimaraes, Christian G. Figueroa-Espada, Rachel S. Riley, Ningqiang Gong, Lulu Xue, Tomasz Sewastianik, Peter S. Dennis, Claudia Loebel, Amanda Chung, Sarah J. Shepherd, Rebecca M. Haley, Alex G. Hamilton, Rakan El-Mayta, Karin Wang, Robert Langer, Daniel G. Anderson, Ruben D. Carrasco, Michael J. Mitchell
Summary: Multiple myeloma (MM) is a hematologic malignancy that colonizes the bone marrow and lacks effective therapies. Endothelial cells in the bone marrow microenvironment, specifically Cyclophilin A (CyPA), play a critical role in MM progression and chemotherapeutic resistance. In this study, researchers developed a nanoparticle-based approach using RNA interference (RNAi) technology to target CyPA and inhibit MM cell extravasation. The strategy demonstrated promising results in vitro and in a murine xenograft model, indicating its potential as a therapeutic strategy for MM.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Alex G. Hamilton, Kelsey L. Swingle, Michael J. Mitchell
Summary: The use of therapeutic nucleic acids has been challenging due to the barriers in their delivery. However, in the past two decades, the development of ionizable lipid nanoparticles as carriers for nucleic acid delivery has overcome these obstacles and found success in clinical applications.
Editorial Material
Engineering, Biomedical
Ningqiang Gong, Alex G. Hamilton, Michael J. Mitchell
Summary: Confining the Zika virus within a self-adjuvanting hydrogel that forms a subcutaneous inflammatory niche stimulates strong immune responses in mice without inducing infection.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Cell & Tissue Engineering
Christian G. Figueroa-Espada, Pedro P. G. Guimaraes, Rachel S. Riley, Lulu Xue, Karin Wang, Michael J. Mitchell
Summary: Our study utilized a lipid-polymer nanoparticle delivery system for RNAi therapy to effectively downregulate ES and CyPA expression and inhibit the colonization and dissemination of MM cells in the bone marrow microenvironment. In vivo delivery of these nanoparticles extended survival in a xenograft mouse model of MM. This combination siRNA therapy presents a potential shift in the treatment of MM and other cancers that colonize the bone marrow.
CELLULAR AND MOLECULAR BIOENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Ajay S. Thatte, Alex G. Hamilton, Benjamin E. Nachod, Alvin J. Mukalel, Margaret M. Billingsley, Rohan Palanki, Kelsey L. Swingle, Michael J. Mitchell
Summary: In this study, an ionizable lipid nanoparticle platform was developed to deliver Foxp3 mRNA to CD4(+) T cells, effectively engineering them into immunosuppressive cells. The results highlight the potential of this platform for engineering immunosuppressive T cells.
Article
Chemistry, Physical
Ningqiang Gong, Xuexiang Han, Lulu Xue, Rakan El-Mayta, Ann E. Metzloff, Margaret M. Billingsley, Alex G. Hamilton, Michael J. Mitchell
Summary: In situ PEGylation of CAR T cells provides a materials-based strategy for safer cellular immunotherapy by blocking cell-to-cell interactions and decreasing toxic cytokine secretion. It also allows for controlled tumor killing and immune response stimulation, mitigating cytokine release syndrome and reducing neurotoxicity.
Article
Chemistry, Multidisciplinary
Hannah C. Safford, Kelsey L. Swingle, Hannah C. Geisler, Alex G. Hamilton, Ajay S. Thatte, Aditi A. Ghalsasi, Margaret M. Billingsley, Mohamad-Gabriel Alameh, Drew Weissman, Michael J. Mitchell
Summary: During healthy pregnancy, the placenta allows for exchange of nutrients and oxygen between the mother and fetus. Placental dysregulation can lead to pregnancy disorders, but lipid nanoparticle-mediated mRNA delivery shows promise in treating these disorders.
Review
Oncology
Mijin Kim, Magdalini Panagiotakopoulou, Chen Chen, Stephen B. B. Ruiz, Karuna Ganesh, Tuomas Tammela, Daniel A. A. Heller
Summary: This review summarizes the use of micro-engineering approaches and nanosensors in establishing multicomponent tumour models and assessing tumour plasticity. These methods are being explored to model the interactions among tumour cells, the tumour microenvironment, and non-tumour tissues, and to measure them in situ and in vivo. The potential of nanosensors for transmitting information about changes in chemical gradients, enzymatic activities, and immune profiles of the tumour microenvironment and circulating analytes is also discussed.
NATURE REVIEWS CANCER
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)