Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance

A glycosylated cationic block poly(beta-peptide) reverses intrinsic antibiotic resistance in all ESKAPE Gram-negative bacteria

(2020) Zhangyong Si et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Poly(2-Oxazoline) Based Functional Mimics of Peptides to Eradicate MRSA Infections and Persisters While Alleviating Antimicrobial Resistance

(2020) Min Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The effect of lipidation and glycosylation on short cationic antimicrobial peptides

(2020) Elizabeth Grimsey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Antimicrobial Peptide-Loaded Nanoparticles as Inhalation Therapy for Pseudomonas aeruginosa Infections

(2020) Chiara Falciani et al.   International Journal of Nanomedicine

Conversion of Broad-Spectrum Antimicrobial Peptides into Species-Specific Antimicrobials Capable of Precisely Targeting Pathogenic Bacteria

(2020) Lin Xu et al.   Scientific Reports

Enhanced cell selectivity of hybrid peptides with potential antimicrobial activity and immunomodulatory effect

(2020) Xiaokang Miao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Synergism of sophoraflavanone G with norfloxacin against effluxing antibiotic-resistant Staphylococcus aureus

(2020) Zhong-Lin Sun et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus

(2020) Wooseong Kim et al.   mBio

Short lipopeptides specifically inhibit the growth of Propionibacterium acnes with antibacterial and anti-inflammatory dual action

(2019) Guang Yang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Development of a novel short 12-meric papiliocin-derived peptide that is effective against Gram-negative sepsis

(2019) Jieun Kim et al.   Scientific Reports

A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus

(2019) Wooseong Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

(2019) Biswajit Mishra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel mechanism of action of ketoconazole: inhibition of the NorA efflux pump system and biofilm formation in multidrug-resistant Staphylococcus aureus

(2019) Rehab M Abd El-Baky et al.   Infection and Drug Resistance

Bioactivity and Bactericidal Mechanism of Histidine-Rich β-Hairpin Peptide Against Gram-Negative Bacteria

(2019) Na Dong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity

(2019) Chao Zhong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure–Function Relationships to Combat Drug-Resistant Fungi and Biofilms

(2019) Peng Tan et al.   ACS Applied Materials & Interfaces

Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria

(2019) Chao Zhong et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Study on the effects of different dimerization positions on biological activity of partial d-Amino acid substitution analogues of Anoplin

(2019) Chao Zhong et al.   MICROBIAL PATHOGENESIS

Central β-turn increases the cell selectivity of imperfectly amphipathic α-helical peptides

(2018) Changxuan Shao et al.   Acta Biomaterialia

Influence of subinhibitory concentrations of NH125 on biofilm formation & virulence factors of Staphylococcus aureus

(2018) Qingzhong Liu et al.   Future Medicinal Chemistry

The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

(2018) Anna de Breij et al.   Science Translational Medicine

Methicillin-resistant Staphylococcus aureus

(2018) Andie S. Lee et al.   Nature Reviews Disease Primers

Ferulic acid derivative inhibits NorA efflux and in combination with ciprofloxacin curtails growth of MRSA in vitro and in vivo

(2018) Niranjana Sri Sundaramoorthy et al.   MICROBIAL PATHOGENESIS

Co-selection of multi-antibiotic resistance in bacterial pathogens in metal and microplastic contaminated environments: An emerging health threat

(2018) Md. Imran et al.   CHEMOSPHERE

Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era

(2018) Jiajun Wang et al.   MEDICINAL RESEARCH REVIEWS

Persistent bacterial infections and persister cells

(2017) Robert A. Fisher et al.   NATURE REVIEWS MICROBIOLOGY

Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides

(2017) Katarzyna E. Greber et al.   Frontiers in Microbiology

Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design

(2017) Jianguo Li et al.   Frontiers in Neuroscience

Using adjuvants and environmental factors to modulate the activity of antimicrobial peptides

(2016) William F. Walkenhorst   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Persister formation in Staphylococcus aureus is associated with ATP depletion

(2016) Brian P. Conlon et al.   Nature Microbiology

N-terminal fatty acylation of peptides spanning the cationic C-terminal segment of bovine β-defensin-2 results in salt-resistant antibacterial activity

(2015) Viswanatha Krishnakumari et al.   BIOPHYSICAL CHEMISTRY

N-Lipidated Peptide Dimers: Effective Antibacterial Agents against Gram-Negative Pathogens through Lipopolysaccharide Permeabilization

(2015) Jun-Jie Koh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials

(2014) Zhan Yuin Ong et al.   ADVANCED DRUG DELIVERY REVIEWS

Antimicrobial potency and selectivity of simplified symmetric-end peptides

(2014) Na Dong et al.   BIOMATERIALS

Antimicrobial Peptides: Promising Compounds Against Pathogenic Microorganisms

(2014) J. Cruz et al.   CURRENT MEDICINAL CHEMISTRY

Effect of hydrophobic modifications in antimicrobial peptides

(2013) Artur Schmidtchen et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria

(2013) Concetta Avitabile et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Divalent cations modulate membrane binding and pore formation of a potent antibiotic peptide analog of alamethicin

(2012) Marco Aquila et al.   CELL CALCIUM

Role of lipids in the interaction of antimicrobial peptides with membranes

(2012) Vitor Teixeira et al.   PROGRESS IN LIPID RESEARCH

Short native antimicrobial peptides and engineered ultrashort lipopeptides: similarities and differences in cell specificities and modes of action

(2011) Maria Luisa Mangoni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ethidium Bromide MIC Screening for Enhanced Efflux Pump Gene Expression or Efflux Activity in Staphylococcus aureus

(2010) D. Patel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE