MAPK signaling regulates c‐MYC for melanoma cell adaptation to asparagine restriction

Dietary restriction of amino acids for Cancer therapy

(2020) Jian-Sheng Kang   Nutrition & Metabolism

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake

(2019) Xazmin H. Lowman et al.   Cell Reports

Translational reprogramming marks adaptation to asparagine restriction in cancer

(2019) Gaurav Pathria et al.   NATURE CELL BIOLOGY

Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

(2018) Dana M. Gwinn et al.   CANCER CELL

Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival

(2018) Gaurav Pathria et al.   EMBO JOURNAL

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

(2018) Akito Nakamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein

(2017) Michel Nofal et al.   MOLECULAR CELL

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

(2017) Oliver D. K. Maddocks et al.   NATURE

Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis

(2017) Ming Yue et al.   Cell Reports

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

(2015) Linchong Sun et al.   CELL RESEARCH

Asparagine Synthetase Expression and Phase I Study With L-Asparaginase Encapsulated in Red Blood Cells in Patients With Pancreatic Adenocarcinoma

(2015) Jean-Baptiste Bachet et al.   PANCREAS

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation

(2014) Rui Chen et al.   JOURNAL OF CELL BIOLOGY

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Tumor glycolysis as a target for cancer therapy: progress and prospects

(2013) Shanmugasundaram Ganapathy-Kanniappan et al.   Molecular Cancer

Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells

(2012) W.-B. Tsai et al.   CANCER RESEARCH

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

The Effect of Leucine Restriction on Akt/mTOR Signaling in Breast Cancer Cell Lines In Vitro and In Vivo

(2011) Gopal Singh et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Arginine Deiminase as a Novel Therapy for Prostate Cancer Induces Autophagy and Caspase-Independent Apoptosis

(2009) R. H. Kim et al.   CANCER RESEARCH

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

ATF4-dependent transcription mediates signaling of amino acid limitation

(2009) Michael S. Kilberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

BCH, an Inhibitor of System L Amino Acid Transporters, Induces Apoptosis in Cancer Cells

(2008) Chun Sung Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Arginine Deprivation as a Targeted Therapy for Cancer

(2008) L. Feun et al.   CURRENT PHARMACEUTICAL DESIGN

Glycogen Synthase Kinase 3β Is a Novel Regulator of High Glucose- and High Insulin-induced Extracellular Matrix Protein Synthesis in Renal Proximal Tubular Epithelial Cells

(2008) Meenalakshmi M. Mariappan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY