Latest developments in tryptophan metabolism: Understanding its role in B cell immunity

Flavivirus-Mediating B Cell Differentiation Into Antibody-Secreting Cells in Humans Is Associated With the Activation of the Tryptophan Metabolism

(2020) Vivian Bonezi et al.   Frontiers in Immunology

Host and Microbial Tryptophan Metabolic Profiling in Multiple Sclerosis

(2020) Lorenzo Gaetani et al.   Frontiers in Immunology

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

(2020) Elizabeth C. Rosser et al.   Cell Metabolism

Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19

(2020) Maria Laura Belladonna et al.   Frontiers in Pharmacology

Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies

(2020) Lijie Zhai et al.   Frontiers in Immunology

Intestinal Dysbiosis and Tryptophan Metabolism in Autoimmunity

(2020) Josephine Brown et al.   Frontiers in Immunology

Treating From the Inside Out: Relevance of Fecal Microbiota Transplantation to Counteract Gut Damage in GVHD and HIV Infection

(2020) Jing Ouyang et al.   Frontiers in Medicine

Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection

(2020) Torben Kimhofer et al.   JOURNAL OF PROTEOME RESEARCH

The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

(2020) H. Blasco et al.   Scientific Reports

IDO Expression in Cancer: Different Compartment, Different Functionality?

(2020) Annabel Meireson et al.   Frontiers in Immunology

Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses

(2020) Lauren M. F. Merlo et al.   Frontiers in Immunology

Tryptophan Metabolism and Related Pathways in Psychoneuroimmunology: The Impact of Nutrition and Lifestyle

(2019) Johanna M. Gostner et al.   NEUROPSYCHOBIOLOGY

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

(2019) Michael Platten et al.   NATURE REVIEWS DRUG DISCOVERY

Tryptophan (Trp) modulates gut homeostasis via aryl hydrocarbon receptor (AhR)

(2019) Meige Sun et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target?

(2019) Yoshihiro Ohue et al.   CANCER SCIENCE

Contribution of IDO to human respiratory syncytial virus infection

(2019) Felipe M. Benavente et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The B-side of Cancer Immunity: The Underrated Tune

(2019) Largeot et al.   Cells

Impact of B cells to the pathophysiology of multiple sclerosis

(2019) Borros M. Arneth   Journal of Neuroinflammation

Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells

(2019) Christopher J.M. Piper et al.   Cell Reports

Current Paradigms of Tolerogenic Dendritic Cells and Clinical Implications for Systemic Lupus Erythematosus

(2019) Ritprajak et al.   Cells

B cell targeted therapies in autoimmune disease

(2019) Jennifer L Barnas et al.   CURRENT OPINION IN IMMUNOLOGY

Generation of memory B cells and their reactivation

(2018) Takeshi Inoue et al.   IMMUNOLOGICAL REVIEWS

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

B-cell responses to HIV infection

(2017) Susan Moir et al.   IMMUNOLOGICAL REVIEWS

Feedback control of AHR signalling regulates intestinal immunity

(2017) Chris Schiering et al.   NATURE

Lactobacillus reuteriinduces gut intraepithelial CD4+CD8αα+T cells

(2017) Luisa Cervantes-Barragan et al.   SCIENCE

Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

(2017) Chai K. Lim et al.   Scientific Reports

Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?

(2017) Andrew L. Mellor et al.   Frontiers in Immunology

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

(2017) Vanessa D. de Mello et al.   Scientific Reports

Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms

(2016) Shahin Aeinehband et al.   BRAIN BEHAVIOR AND IMMUNITY

Aryl hydrocarbon receptor is required for optimal B‐cell proliferation

(2016) Matteo Villa et al.   EMBO JOURNAL

The aryl hydrocarbon receptor controls cell-fate decisions in B cells

(2016) Bharat Vaidyanathan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection

(2016) Xavier Dagenais-Lussier et al.   JOURNAL OF VIROLOGY

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease

(2016) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

The effect of tryptophol on the bacteriophage infection in high-temperature environment

(2015) Min Jin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The kynurenine pathway activities in a sub-Saharan HIV/AIDS population

(2015) Priyesh Bipath et al.   BMC INFECTIOUS DISEASES

Suppressive functions of B cells in infectious diseases: Fig. 1.

(2015) Ping Shen et al.   INTERNATIONAL IMMUNOLOGY

Increased Tryptophan Catabolism Is Associated With Increased Frequency of CD161+Tc17/MAIT Cells and Lower CD4+ T-Cell Count in HIV-1 Infected Patients on cART After 2 Years of Follow-Up

(2015) Julie C. Gaardbo et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

B Cell–Intrinsic IDO1 Regulates Humoral Immunity to T Cell–Independent Antigens

(2015) Rahul Shinde et al.   JOURNAL OF IMMUNOLOGY

Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection

(2015) Mohammad-Ali Jenabian et al.   JOURNAL OF INFECTIOUS DISEASES

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection

(2014) M.-A. Jenabian et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Regulatory B cells are induced by gut microbiota–driven interleukin-1β and interleukin-6 production

(2014) Elizabeth C Rosser et al.   NATURE MEDICINE

Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production

(2014) Margaret M. Lowe et al.   PLoS One

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

CYP1A1 Regulates Breast Cancer Proliferation and Survival

(2013) Mariangellys Rodriguez et al.   MOLECULAR CANCER RESEARCH

A Family of Indoles Regulate Virulence and Shiga Toxin Production in Pathogenic E. coli

(2013) Bettina Bommarius et al.   PLoS One

HIV-1 Tat Protein Induces the Production of IDO in Human Monocyte Derived-Dendritic Cells through a Direct Mechanism: Effect on T Cells Proliferation

(2013) Rémi Planès et al.   PLoS One

Distinct Tryptophan Catabolism and Th17/Treg Balance in HIV Progressors and Elite Controllers

(2013) Mohammad-Ali Jenabian et al.   PLoS One

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease

(2010) D. Favre et al.   Science Translational Medicine

Bioactive Secondary Metabolites from a New Terrestrial Streptomyces sp. TN262

(2009) Lobna Elleuch et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

The Immunoregulatory Enzyme IDO Paradoxically Drives B Cell-Mediated Autoimmunity

(2009) G. N. Scott et al.   JOURNAL OF IMMUNOLOGY