Molecular mechanisms employed by enteric bacterial pathogens to antagonise host innate immunity

Vying for the control of inflammasomes: The cytosolic frontier of enteric bacterial pathogen–host interactions

(2020) Julia Sanchez‐Garrido et al.   CELLULAR MICROBIOLOGY

Characterization of pyrin dephosphorylation and inflammasome activation in macrophages as triggered by the Yersinia effectors YopE and YopT

(2019) Natasha P. Medici et al.   INFECTION AND IMMUNITY

Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways

(2019) Joshua PM Newson et al.   MOLECULAR & CELLULAR PROTEOMICS

Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease

(2019) Kyle Tretina et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

(2019) Yue Xu et al.   CELL

SopF, a phosphoinositide binding effector, promotes the stability of the nascent Salmonella-containing vacuole

(2019) Nicole Lau et al.   PLoS Pathogens

Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization

(2019) Ioanna Panagi et al.   Cell Host & Microbe

Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection

(2019) Trung H.M. Pham et al.   Cell Host & Microbe

The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3

(2019) Kyle D. Gibbs et al.   Cell Host & Microbe

Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

(2019) Saskia D. Günther et al.   Nature Microbiology

Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria

(2018) Matthew T. Sorbara et al.   Cell Host & Microbe

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Synthetic bottom-up approach reveals the complex interplay ofShigellaeffectors in regulation of epithelial cell death

(2018) Xiangyu Mou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nε-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function

(2018) Wang Liu et al.   Nature Microbiology

Structure–function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-κB

(2018) Elliott Jennings et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose

(2018) Ping Zhou et al.   NATURE

ADP‐heptose is a newly identified pathogen‐associated molecular pattern of Shigella flexneri

(2018) Diego García‐Weber et al.   EMBO REPORTS

NleB/SseK effectors fromCitrobacter rodentium,Escherichia coli, andSalmonella entericadisplay distinct differences in host substrate specificity

(2017) Samir El Qaidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence

(2017) Peng Li et al.   NATURE

Epithelial cells detect functional type III secretion system of enteropathogenic Escherichia coli through a novel NF-κB signaling pathway

(2017) Yael Litvak et al.   PLoS Pathogens

A Type III Effector NleF from EHEC Inhibits Epithelial Inflammatory Cell Death by Targeting Caspase-4

(2017) Ting Song et al.   Biomed Research International

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

(2017) Jaclyn S. Pearson et al.   Nature Microbiology

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome

(2016) Lawton K. Chung et al.   Cell Host & Microbe

Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation

(2016) Si Ming Man et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells

(2016) M A Pallett et al.   Mucosal Immunology

Inhibition of Nuclear Transport of NF-ĸB p65 by the Salmonella Type III Secretion System Effector SpvD

(2016) Nathalie Rolhion et al.   PLoS Pathogens

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation

(2016) Dmitry Ratner et al.   PLoS Pathogens

A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis

(2016) Hui Sun et al.   PLoS Pathogens

Shigella flexneri suppresses NF-κB activation by inhibiting linear ubiquitin chain ligation

(2016) Maarten F. de Jong et al.   Nature Microbiology

Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD

(2015) Erin E. Zwack et al.   mBio

Enteropathogenic Escherichia coli Uses NleA to Inhibit NLRP3 Inflammasome Activation

(2015) Hilo Yen et al.   PLoS Pathogens

Integrin-Mediated First Signal for Inflammasome Activation in Intestinal Epithelial Cells

(2014) J. Thinwa et al.   JOURNAL OF IMMUNOLOGY

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

IQGAP1 Is Important for Activation of Caspase-1 in Macrophages and Is Targeted by Yersinia pestis Type III Effector YopM

(2014) L. K. Chung et al.   mBio

The Shigella OspC3 Effector Inhibits Caspase-4, Antagonizes Inflammatory Cell Death, and Promotes Epithelial Infection

(2013) Taira Kobayashi et al.   Cell Host & Microbe

A Shigella Effector Dampens Inflammation by Regulating Epithelial Release of Danger Signal ATP through Production of the Lipid Mediator PtdIns5P

(2013) Andrea Puhar et al.   IMMUNITY

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

(2013) Shan Li et al.   NATURE

A type III effector antagonizes death receptor signalling during bacterial gut infection

(2013) Jaclyn S. Pearson et al.   NATURE

The E. coli Effector Protein NleF Is a Caspase Inhibitor

(2013) Sonja Blasche et al.   PLoS One

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses

(2012) Na Dong et al.   CELL

The Yersinia Virulence Effector YopM Binds Caspase-1 to Arrest Inflammasome Assembly and Processing

(2012) Christopher N. LaRock et al.   Cell Host & Microbe

The Transcriptional Specificity of NF-κB Dimers Is Coded within the κB DNA Response Elements

(2012) Vivien Ya-Fan Wang et al.   Cell Reports

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation

(2011) Jaclyn S. Pearson et al.   MOLECULAR MICROBIOLOGY

Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

(2011) Li Zhang et al.   NATURE

A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System

(2010) Igor E. Brodsky et al.   Cell Host & Microbe

Metalloprotease type III effectors that specifically cleave JNK and NF-κB

(2010) Kobi Baruch et al.   EMBO JOURNAL

Proteasome-independent Degradation of Canonical NFκB Complex Components by the NleC Protein of PathogenicEscherichia coli

(2010) Sabrina Mühlen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65

(2010) Hayley J. Newton et al.   PLoS Pathogens

NleC, a Type III Secretion Protease, Compromises NF-κB Activation by Targeting p65/RelA

(2010) Hilo Yen et al.   PLoS Pathogens