CK2 Inhibits TIMELESS Nuclear Export and Modulates CLOCK Transcriptional Activity to Regulate Circadian Rhythms

EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology inDrosophila

(2020) Antoine Abrieux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-GlcNAcylation of PERIOD regulates its interaction with CLOCK and timing of circadian transcriptional repression

(2019) Ying H. Li et al.   PLoS Genetics

PERIOD-controlled deadenylation of thetimelesstranscript in theDrosophilacircadian clock

(2019) Brigitte Grima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Clock Genes and the Transcriptional Architecture of the Clock Mechanism

(2019) Kimberly H. Cox et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Molecular mechanisms and physiological importance of circadian rhythms

(2019) Alina Patke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SUR-8 interacts with PP1-87B to stabilize PERIOD and regulate circadian rhythms in Drosophila

(2019) Yongbo Xue et al.   PLoS Genetics

New Drosophila Circadian Clock Mutants Affecting Temperature Compensation Induced by Targeted Mutagenesis of Timeless

(2019) Samarjeet Singh et al.   Frontiers in Physiology

Nuclear export-dependent degradation of the carbon catabolite repressor CreA is regulated by a region located near the C-terminus in Aspergillus oryzae

(2018) Mizuki Tanaka et al.   MOLECULAR MICROBIOLOGY

CK1/Doubletime activity delays transcription activation in the circadian clock

(2018) Deniz Top et al.   eLife

mTOR-dependent phosphorylation controls TFEB nuclear export

(2018) Gennaro Napolitano et al.   Nature Communications

CK1α Collaborates with DOUBLETIME to Regulate PERIOD Function in the Drosophila Circadian Clock

(2018) Vu H. Lam et al.   JOURNAL OF NEUROSCIENCE

Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila

(2018) Iryna Shakhmantsir et al.   eLife

Circadian Rhythms and Sleep in Drosophila melanogaster

(2017) Christine Dubowy et al.   GENETICS

A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms

(2017) Chelsea L. Gustafson et al.   MOLECULAR CELL

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

(2017) Ho Yee Joyce Fung et al.   eLife

Circadian Rhythms and Sleep in Drosophila melanogaster

(2017) Christine Dubowy et al.   GENETICS

Differential rhythmicity: detecting altered rhythmicity in biological data

(2016) Paul F. Thaben et al.   BIOINFORMATICS

GSK-3 and CK2 Kinases Converge on Timeless to Regulate the Master Clock

(2016) Deniz Top et al.   Cell Reports

CLOCKWORK ORANGE Enhances PERIOD Mediated Rhythms in Transcriptional Repression by Antagonizing E-box Binding by CLOCK-CYCLE

(2016) Jian Zhou et al.   PLoS Genetics

Identification of Light-Sensitive Phosphorylation Sites on PERIOD That Regulate the Pace of Circadian Rhythms in Drosophila

(2015) Evrim Yildirim et al.   MOLECULAR AND CELLULAR BIOLOGY

Daytime CLOCK Dephosphorylation Is Controlled by STRIPAK Complexes in Drosophila

(2015) Simonetta Andreazza et al.   Cell Reports

The Catalytic and Non-catalytic Functions of the Brahma Chromatin-Remodeling Protein Collaborate to Fine-Tune Circadian Transcription in Drosophila

(2015) Rosanna S. Kwok et al.   PLoS Genetics

Drosophila TIM Binds Importin α1, and Acts as an Adapter to Transport PER to the Nucleus

(2015) A. Reum Jang et al.   PLoS Genetics

Phosphorylation of the Transcription Activator CLOCK Regulates Progression through a ∼24-h Feedback Loop to Influence the Circadian Period inDrosophila

(2014) Guruswamy Mahesh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detecting Rhythms in Time Series with RAIN

(2014) Paul F. Thaben et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Dynamics of the circadian clock protein PERIOD2 in living cells

(2014) R. Ollinger et al.   JOURNAL OF CELL SCIENCE

Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock

(2013) Krista Kaasik et al.   Cell Metabolism

Flavin reduction activates Drosophila cryptochrome

(2013) A. T. Vaidya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for Drosophila ATX2 in Activation of PER Translation and Circadian Behavior

(2013) Y. Zhang et al.   SCIENCE

The CK2 Kinase Stabilizes CLOCK and Represses Its Activity in the Drosophila Circadian Oscillator

(2013) Áron Szabó et al.   PLOS BIOLOGY

Cooperative Interaction between Phosphorylation Sites on PERIOD Maintains Circadian Period in Drosophila

(2013) David S. Garbe et al.   PLoS Genetics

Phosphorylation meets nuclear import: a review

(2012) Jonathan D Nardozzi et al.   Cell Communication and Signaling

Effects of Aging on the Molecular Circadian Oscillations inDrosophila

(2012) Kuntol Rakshit et al.   CHRONOBIOLOGY INTERNATIONAL

CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila

(2012) W. Luo et al.   GENES & DEVELOPMENT

A role for O-GlcNAcylation in setting circadian clock speed

(2012) E. Y. Kim et al.   GENES & DEVELOPMENT

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

CULLIN-3 Controls TIMELESS Oscillations in the Drosophila Circadian Clock

(2012) Brigitte Grima et al.   PLOS BIOLOGY

NEMO/NLK Phosphorylates PERIOD to Initiate a Time-Delay Phosphorylation Circuit that Sets Circadian Clock Speed

(2011) Joanna C. Chiu et al.   CELL

NEMO Kinase Contributes to Core Period Determination by Slowing the Pace of the Drosophila Circadian Oscillator

(2011) Wangjie Yu et al.   CURRENT BIOLOGY

Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression

(2011) K. C. Abruzzi et al.   GENES & DEVELOPMENT

A Key Temporal Delay in the Circadian Cycle ofDrosophilaIs Mediated by a Nuclear Localization Signal in the Timeless Protein

(2011) Lino Saez et al.   GENETICS

Post-Translational Regulation and Nuclear Entry of TIMELESS and PERIOD Are Affected in New timeless Mutant

(2011) T. Hara et al.   JOURNAL OF NEUROSCIENCE

Drosophila timeless2 Is Required for Chromosome Stability and Circadian Photoreception

(2010) Clara Benna et al.   CURRENT BIOLOGY

Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA

(2010) J. S. Menet et al.   GENES & DEVELOPMENT

A Hierarchical Phosphorylation Cascade That Regulates the Timing of PERIOD Nuclear Entry Reveals Novel Roles for Proline-Directed Kinases and GSK-3 /SGG in Circadian Clocks

(2010) H. W. Ko et al.   JOURNAL OF NEUROSCIENCE

Reaction mechanism of Drosophila cryptochrome

(2010) N. Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Light-Dependent Interactions between the Drosophila Circadian Clock Factors Cryptochrome, Jetlag, and Timeless

(2009) Nicolai Peschel et al.   CURRENT BIOLOGY

Phosphorylation modulates rapid nucleocytoplasmic shuttling and cytoplasmic accumulation of Neurospora clock protein FRQ on a circadian time scale

(2009) A. C.R. Diernfellner et al.   GENES & DEVELOPMENT

Sequential and Compartment-specific Phosphorylation Controls the Life Cycle of the Circadian CLOCK Protein

(2009) Hsiu-Cheng Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DOUBLETIME Plays a Noncatalytic Role To Mediate CLOCK Phosphorylation and Repress CLOCK-Dependent Transcription within the Drosophila Circadian Clock

(2009) W. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock

(2008) J. C. Chiu et al.   GENES & DEVELOPMENT

TIMELESS Is an Important Mediator of CK2 Effects on Circadian Clock Function In Vivo

(2008) R.-A. Meissner et al.   JOURNAL OF NEUROSCIENCE

Cryptochromes Define a Novel Circadian Clock Mechanism in Monarch Butterflies That May Underlie Sun Compass Navigation

(2008) Haisun Zhu et al.   PLOS BIOLOGY