Accumulation of cellular prion protein within β‐amyloid oligomer plaques in aged human brains

The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s disease

(2020) Baayla D. C. Boon et al.   ACTA NEUROPATHOLOGICA

Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition

(2019) Carine Z. J. Lim et al.   Nature Communications

Aβ oligomers trigger and accelerate Aβ seeding

(2019) Natalie Katzmarski et al.   BRAIN PATHOLOGY

Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein

(2019) Luis Aragão Gomes et al.   ACTA NEUROPATHOLOGICA

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

(2019) Grant T. Corbett et al.   ACTA NEUROPATHOLOGICA

Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in aDrosophilamodel of Alzheimer disease

(2018) Nadine D. Younan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease

(2017) Santiago V. Salazar et al.   JOURNAL OF NEUROSCIENCE

Aβ seeds and prions: How close the fit?

(2017) Jay Rasmussen et al.   Prion

Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP

(2017) O. Klementieva et al.   Nature Communications

Exosomes and the Prion Protein: More than One Truth

(2017) Alexander Hartmann et al.   Frontiers in Neuroscience

Prion Protein is Reduced in Aging and in Sporadic but not in Familial Alzheimer's Disease

(2017) Isobel J. Whitehouse et al.   JOURNAL OF ALZHEIMERS DISEASE

Human-to-mouse prion-like propagation of mutant huntingtin protein

(2016) Iksoo Jeon et al.   ACTA NEUROPATHOLOGICA

Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity

(2016) Clemens Falker et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

(2015) Heledd H. Jarosz-Griffiths et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

The prion protein constitutively controls neuronal store-operated Ca2+ entry through Fyn kinase

(2015) Agnese De Mario et al.   Frontiers in Cellular Neuroscience

Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons

(2015) Tomohiro Umeda et al.   Acta Neuropathologica Communications

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide

(2014) Kohei Yuyama et al.   FEBS LETTERS

Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration

(2013) Magdalena A. Kuszczyk et al.   AMERICAN JOURNAL OF PATHOLOGY

An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicityin Vivo

(2013) Brian R. Fluharty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E693Δ (Osaka) mutation in amyloid precursor protein potentiates cholesterol-mediated intracellular amyloid β toxicity via its impaired cholesterol efflux

(2013) Sachiko Nomura et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Different antigenicities of the N-terminal region of cellular and scrapie prion proteins

(2013) Yuko Ushiki-Kaku et al.   MICROBIOLOGY AND IMMUNOLOGY

Cellular prion protein modulates β-amyloid deposition in aged APP/PS1 transgenic mice

(2013) Lara Ordóñez-Gutiérrez et al.   NEUROBIOLOGY OF AGING

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Prion Protein Is Decreased in Alzheimer's Brain and Inversely Correlates with BACE1 Activity, Amyloid-β Levels and Braak Stage

(2013) Isobel J. Whitehouse et al.   PLoS One

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity

(2013) Andrew J. Nicoll et al.   Nature Communications

The Complex PrPc-Fyn Couples Human Oligomeric A  with Pathological Tau Changes in Alzheimer's Disease

(2012) M. Larson et al.   JOURNAL OF NEUROSCIENCE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Amyloid-beta oligomers increase the localization of prion protein at the cell surface

(2011) Fabiana A. Caetano et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein

(2011) A. E. Barry et al.   JOURNAL OF NEUROSCIENCE

Prion protein at the crossroads of physiology and disease

(2011) Emiliano Biasini et al.   TRENDS IN NEUROSCIENCES

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

(2011) Darragh B. Freir et al.   Nature Communications

Monoclonal Antibody Against the Turn of the 42-Residue Amyloid β-Protein at Positions 22 and 23

(2010) Kazuma Murakami et al.   ACS Chemical Neuroscience

Interaction between Human Prion Protein and Amyloid-β (Aβ) Oligomers

(2010) Shugui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain

(2010) Reisuke H. Takahashi et al.   NEUROPATHOLOGY

The cellular prion protein and its role in Alzheimer disease

(2010) J. L. Velayos et al.   Prion

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A prion protein connection

(2009) Moustapha Cisse et al.   NATURE

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

(2009) Jennifer L. Tomic et al.   NEUROBIOLOGY OF DISEASE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE