Allosteric signaling in C-linker and cyclic nucleotide-binding domain of HCN2 channels

Novel Fluorescent Cyclic Nucleotide Derivatives to Study CNG and HCN Channel Function

(2019) Maik Otte et al.   BIOPHYSICAL JOURNAL

Biallelic mutation of human SLC6A6 encoding the taurine transporter TAUT is linked to early retinal degeneration

(2019) Markus N. Preising et al.   FASEB JOURNAL

Basal Histamine H4 Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif

(2019) David Wifling et al.   CHEMISTRY-A EUROPEAN JOURNAL

The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

(2019) Alessandro Porro et al.   eLife

Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating

(2019) Marina A Kasimova et al.   eLife

Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide–gated cation channel

(2018) Christine Groß et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner

(2018) Mallikarjuna Rao Sunkara et al.   JOURNAL OF GENERAL PHYSIOLOGY

Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family

(2018) Claudia P. Alvarez-Baron et al.   JOURNAL OF GENERAL PHYSIOLOGY

Recognition motif and mechanism of ripening inhibitory peptides in plant hormone receptor ETR1

(2018) Dalibor Milić et al.   Scientific Reports

Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation

(2018) Maik Otte et al.   Scientific Reports

Avoiding False Positive Conclusions in Molecular Simulation: The Importance of Replicas

(2018) Bernhard Knapp et al.   Journal of Chemical Theory and Computation

Bipolar switching by HCN voltage sensor underlies hyperpolarization activation

(2018) John Cowgill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ensemble- and Rigidity Theory-Based Perturbation Approach To Analyze Dynamic Allostery

(2017) Christopher Pfleger et al.   Journal of Chemical Theory and Computation

Rigidity Theory-Based Approximation of Vibrational Entropy Changes upon Binding to Biomolecules

(2017) Holger Gohlke et al.   Journal of Chemical Theory and Computation

A half-site multimeric enzyme achieves its cooperativity without conformational changes

(2017) Mirella Vivoli et al.   Scientific Reports

Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides

(2015) Susanne Thon et al.   BIOPHYSICAL JOURNAL

Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides

(2015) Hannah A. DeBerg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning

(2015) Chad W. Hopkins et al.   Journal of Chemical Theory and Computation

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Structure of the SthK Carboxy-Terminal Region Reveals a Gating Mechanism for Cyclic Nucleotide-Modulated Ion Channels

(2015) Divya Kesters et al.   PLoS One

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Double electron–electron resonance reveals cAMP-induced conformational change in HCN channels

(2014) Michael C. Puljung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elementary Functional Properties of Single HCN2 Channels

(2013) S. Thon et al.   BIOPHYSICAL JOURNAL

A Secondary Structural Transition in the C-helix Promotes Gating of Cyclic Nucleotide-regulated Ion Channels

(2013) Michael C. Puljung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constraint Network Analysis (CNA): A Python Software Package for Efficiently Linking Biomacromolecular Structure, Flexibility, (Thermo-)Stability, and Function

(2013) Christopher Pfleger et al.   Journal of Chemical Information and Modeling

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald

(2013) Romelia Salomon-Ferrer et al.   Journal of Chemical Theory and Computation

Hysteresis of ligand binding in CNGA2 ion channels

(2013) Vasilica Nache et al.   Nature Communications

Normal-Mode-Analysis-Guided Investigation of Crucial Intersubunit Contacts in the cAMP-Dependent Gating in HCN Channels

(2012) Farzana Marni et al.   BIOPHYSICAL JOURNAL

Global and local indices for characterizing biomolecular flexibility and rigidity

(2012) Christopher Pfleger et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Probability Fluxes and Transition Paths in a Markovian Model Describing Complex Subunit Cooperativity in HCN2 Channels

(2012) Klaus Benndorf et al.   PLoS Computational Biology

Energetics of Cyclic AMP Binding to HCN Channel C Terminus Reveal Negative Cooperativity

(2011) Sarah S. Chow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels

(2011) Jana Kusch et al.   Nature Chemical Biology

Exploring HCN channels as novel drug targets

(2011) Otilia Postea et al.   NATURE REVIEWS DRUG DISCOVERY

Interdependence of Receptor Activation and Ligand Binding in HCN2 Pacemaker Channels

(2010) Jana Kusch et al.   NEURON

Protein rigidity and thermophilic adaptation

(2010) Sebastian Radestock et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mapping the structure and conformational movements of proteins with transition metal ion FRET

(2009) Justin W Taraska et al.   NATURE METHODS

HCN channels: Structure, cellular regulation and physiological function

(2008) C. Wahl-Schott et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exploiting the Link between Protein Rigidity and Thermostability for Data-Driven Protein Engineering

(2008) S. Radestock et al.   ENGINEERING IN LIFE SCIENCES

C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels

(2008) Kimberley B. Craven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY